New trends in adjunctive treatment and diagnosis in medication-related osteonecrosis of the jaw: A 10-year review
Medication-related osteonecrosis of the jaw (MRONJ) is a major disease under study for over the last twenty years. Different classifications have been proposed and many therapies for the different stages have been applied. The evolution of treatments lead to an increasingly conservative approach. Nu...
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| Veröffentlicht in: | Journal of biological regulators and homeostatic agents 2020-11, Vol.34 (6 Suppl. 2), p.37 |
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| creator | De Santis, D Gelpi, F Luciano, U Zarantonello, M Poscolere, A Modena, N Faccioni, P Causarano, G Finotti, M Zotti, F Magi, M Iurlaro, A Nocini, P F Alberti, C Zangani, A Capocasale, G Donadello, D Nocini, R Bernardello, F |
| description | Medication-related osteonecrosis of the jaw (MRONJ) is a major disease under study for over the last twenty years. Different classifications have been proposed and many therapies for the different stages have been applied. The evolution of treatments lead to an increasingly conservative approach. Numerous adjuvant treatments have been proposed in the last decade. All these complementary treatments have been proposed mainly to resolve or reduce the painful stress, predominantly caused by bacterial infection, simplifying the wound healing process and improving patients' compliance. Nowadays "secondary" treatments, such as autologous platelet concentrates (APCs, more specifically PRP, PRGF or PRF), hyperbaric oxygen (HBO), Auto/tetracycline fluorescence-guided bone surgery (AF-GBS/TF-GBS), medical drugs like teriparatide or the combination between pentoxifylline and tocopherol, fluorodeoxyglucose positron emission tomography (FDG-PET), laser and/or low-laser therapy and ozone therapy are more or less well documented and known considering their clinical effectiveness. The aim of the present review is the evaluation of the quantity and quality of scientific studies concerning this specific topic. |
| format | Article |
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Different classifications have been proposed and many therapies for the different stages have been applied. The evolution of treatments lead to an increasingly conservative approach. Numerous adjuvant treatments have been proposed in the last decade. All these complementary treatments have been proposed mainly to resolve or reduce the painful stress, predominantly caused by bacterial infection, simplifying the wound healing process and improving patients' compliance. Nowadays "secondary" treatments, such as autologous platelet concentrates (APCs, more specifically PRP, PRGF or PRF), hyperbaric oxygen (HBO), Auto/tetracycline fluorescence-guided bone surgery (AF-GBS/TF-GBS), medical drugs like teriparatide or the combination between pentoxifylline and tocopherol, fluorodeoxyglucose positron emission tomography (FDG-PET), laser and/or low-laser therapy and ozone therapy are more or less well documented and known considering their clinical effectiveness. The aim of the present review is the evaluation of the quantity and quality of scientific studies concerning this specific topic.</description><identifier>ISSN: 0393-974X</identifier><identifier>PMID: 33541063</identifier><language>eng</language><publisher>Italy</publisher><subject>Anti-Bacterial Agents - therapeutic use ; Bisphosphonate-Associated Osteonecrosis of the Jaw - diagnosis ; Bisphosphonate-Associated Osteonecrosis of the Jaw - therapy ; Bone Density Conservation Agents - adverse effects ; Diphosphonates - adverse effects ; Humans ; Laser Therapy ; Tocopherols - therapeutic use ; Treatment Outcome</subject><ispartof>Journal of biological regulators and homeostatic agents, 2020-11, Vol.34 (6 Suppl. 2), p.37</ispartof><rights>Copyright 2020 Biolife Sas. www.biolifesas.org.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33541063$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Santis, D</creatorcontrib><creatorcontrib>Gelpi, F</creatorcontrib><creatorcontrib>Luciano, U</creatorcontrib><creatorcontrib>Zarantonello, M</creatorcontrib><creatorcontrib>Poscolere, A</creatorcontrib><creatorcontrib>Modena, N</creatorcontrib><creatorcontrib>Faccioni, P</creatorcontrib><creatorcontrib>Causarano, G</creatorcontrib><creatorcontrib>Finotti, M</creatorcontrib><creatorcontrib>Zotti, F</creatorcontrib><creatorcontrib>Magi, M</creatorcontrib><creatorcontrib>Iurlaro, A</creatorcontrib><creatorcontrib>Nocini, P F</creatorcontrib><creatorcontrib>Alberti, C</creatorcontrib><creatorcontrib>Zangani, A</creatorcontrib><creatorcontrib>Capocasale, G</creatorcontrib><creatorcontrib>Donadello, D</creatorcontrib><creatorcontrib>Nocini, R</creatorcontrib><creatorcontrib>Bernardello, F</creatorcontrib><title>New trends in adjunctive treatment and diagnosis in medication-related osteonecrosis of the jaw: A 10-year review</title><title>Journal of biological regulators and homeostatic agents</title><addtitle>J Biol Regul Homeost Agents</addtitle><description>Medication-related osteonecrosis of the jaw (MRONJ) is a major disease under study for over the last twenty years. Different classifications have been proposed and many therapies for the different stages have been applied. The evolution of treatments lead to an increasingly conservative approach. Numerous adjuvant treatments have been proposed in the last decade. All these complementary treatments have been proposed mainly to resolve or reduce the painful stress, predominantly caused by bacterial infection, simplifying the wound healing process and improving patients' compliance. Nowadays "secondary" treatments, such as autologous platelet concentrates (APCs, more specifically PRP, PRGF or PRF), hyperbaric oxygen (HBO), Auto/tetracycline fluorescence-guided bone surgery (AF-GBS/TF-GBS), medical drugs like teriparatide or the combination between pentoxifylline and tocopherol, fluorodeoxyglucose positron emission tomography (FDG-PET), laser and/or low-laser therapy and ozone therapy are more or less well documented and known considering their clinical effectiveness. 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Different classifications have been proposed and many therapies for the different stages have been applied. The evolution of treatments lead to an increasingly conservative approach. Numerous adjuvant treatments have been proposed in the last decade. All these complementary treatments have been proposed mainly to resolve or reduce the painful stress, predominantly caused by bacterial infection, simplifying the wound healing process and improving patients' compliance. Nowadays "secondary" treatments, such as autologous platelet concentrates (APCs, more specifically PRP, PRGF or PRF), hyperbaric oxygen (HBO), Auto/tetracycline fluorescence-guided bone surgery (AF-GBS/TF-GBS), medical drugs like teriparatide or the combination between pentoxifylline and tocopherol, fluorodeoxyglucose positron emission tomography (FDG-PET), laser and/or low-laser therapy and ozone therapy are more or less well documented and known considering their clinical effectiveness. The aim of the present review is the evaluation of the quantity and quality of scientific studies concerning this specific topic.</abstract><cop>Italy</cop><pmid>33541063</pmid></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Anti-Bacterial Agents - therapeutic use Bisphosphonate-Associated Osteonecrosis of the Jaw - diagnosis Bisphosphonate-Associated Osteonecrosis of the Jaw - therapy Bone Density Conservation Agents - adverse effects Diphosphonates - adverse effects Humans Laser Therapy Tocopherols - therapeutic use Treatment Outcome |
| title | New trends in adjunctive treatment and diagnosis in medication-related osteonecrosis of the jaw: A 10-year review |
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