Different patterns of gray matter atrophy in behavioral variant frontotemporal dementia with and without episodic memory impairment
Background Differentiating patients with behavioral variant frontotemporal dementia (bvFTD) from Alzheimer's disease (AD) is important as these two conditions have distinct treatment and prognosis. Using episodic impairment and medial temporal lobe atrophy as a tool to make this distinction has...
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| Veröffentlicht in: | International journal of geriatric psychiatry 2021-12, Vol.36 (12), p.1848-1857 |
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| container_title | International journal of geriatric psychiatry |
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| creator | Resende, Elisa de Paula França Hornberger, Michael Guimarães, Henrique Cerqueira Gambogi, Leandro Boson Mariano, Luciano Inácio Teixeira, Antônio Lúcio Caramelli, Paulo Cruz de Souza, Leonardo |
| description | Background
Differentiating patients with behavioral variant frontotemporal dementia (bvFTD) from Alzheimer's disease (AD) is important as these two conditions have distinct treatment and prognosis. Using episodic impairment and medial temporal lobe atrophy as a tool to make this distinction has been debatable in the recent literature, as some patients with bvFTD can also have episodic memory impairment and medial temporal lobe atrophy early in the disease.
Objectives
To compare brain atrophy patterns of patients with bvFTD with and without episodic memory impairment to that of patients with AD.
Methods
We analyzed 19 patients with bvFTD, 21 with AD and 21 controls, matched by age, sex, and years of education. They underwent brain MRI and the memory test from the Brief Cognitive Battery (BCB) to assess episodic memory. We then categorized the bvFTD group into amnestic (BCB delayed recall score |
| doi_str_mv | 10.1002/gps.5503 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_pubmed_primary_33527441</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2590969435</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3833-7f79daf1bd5ea947ab6a1fd8b4aa979469e27d70bc75265d55ce9d14a6e71f173</originalsourceid><addsrcrecordid>eNp1kUFrFTEQx4NY7LMKfgIJePGybbK7STZHabUKhQrqOcxuJn0pu5s1yba8s1_cvNeqIPQ0w8xvfgz8CXnD2SlnrD67WdKpEKx5RjacaV1xLuVzsmFdJypZN-yYvEzplrGy490Lctw0olZtyzfk14V3DiPOmS6QM8Y50eDoTYQdnQ4DCjmGZbujfqY9buHOhwgjvYPooVy5GOYcMk7LYWxxKi4P9N7nLYXZHpqwZoqLT8H6gU44hVh00wI-7ulX5MjBmPD1Yz0hPz59_H7-ubq6vvxy_uGqGpquaSrllLbgeG8Fgm4V9BK4s13fAmilW6mxVlaxflCilsIKMaC2vAWJijuumhPy_sG7xPBzxZTN5NOA4wgzhjWZuu2E4LLWsqDv_kNvwxrn8p2phWZa6rYR_4RDDClFdGaJfoK4M5yZfTCmBGP2wRT07aNw7Se0f8E_SRSgegDu_Yi7J0Xm8uu3g_A3Gn2aQw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2590969435</pqid></control><display><type>article</type><title>Different patterns of gray matter atrophy in behavioral variant frontotemporal dementia with and without episodic memory impairment</title><source>Wiley Online Library</source><creator>Resende, Elisa de Paula França ; Hornberger, Michael ; Guimarães, Henrique Cerqueira ; Gambogi, Leandro Boson ; Mariano, Luciano Inácio ; Teixeira, Antônio Lúcio ; Caramelli, Paulo ; Cruz de Souza, Leonardo</creator><creatorcontrib>Resende, Elisa de Paula França ; Hornberger, Michael ; Guimarães, Henrique Cerqueira ; Gambogi, Leandro Boson ; Mariano, Luciano Inácio ; Teixeira, Antônio Lúcio ; Caramelli, Paulo ; Cruz de Souza, Leonardo</creatorcontrib><description>Background
Differentiating patients with behavioral variant frontotemporal dementia (bvFTD) from Alzheimer's disease (AD) is important as these two conditions have distinct treatment and prognosis. Using episodic impairment and medial temporal lobe atrophy as a tool to make this distinction has been debatable in the recent literature, as some patients with bvFTD can also have episodic memory impairment and medial temporal lobe atrophy early in the disease.
Objectives
To compare brain atrophy patterns of patients with bvFTD with and without episodic memory impairment to that of patients with AD.
Methods
We analyzed 19 patients with bvFTD, 21 with AD and 21 controls, matched by age, sex, and years of education. They underwent brain MRI and the memory test from the Brief Cognitive Battery (BCB) to assess episodic memory. We then categorized the bvFTD group into amnestic (BCB delayed recall score <7) and non‐amnestic.
Results
The amnestic bvFTD group (n = 8) had significant gray matter atrophy in the left parahippocampal gyrus, right cingulate and precuneus regions compared with the nonamnestic group. Compared with AD, amnestic bvFTD had more atrophy in the left fusiform cortex, left insula, left inferior temporal gyrus and right temporal pole, whereas patients with AD had more atrophy in the left hippocampus, left frontal pole and left angular gyrus.
Conclusions
There is a group of amnestic bvFTD patients with episodic memory dysfunction and significant atrophy in medial temporal structures, which poses a challenge in considering only these features when differentiating bvFTD from AD clinically.
Key Points
Patients with behavioral variant Frontotemporal dementia can have impairment in visual episodic memory with temporal lobe atrophy, even when compared with patients with amnestic Alzheimer's disease</description><identifier>ISSN: 0885-6230</identifier><identifier>EISSN: 1099-1166</identifier><identifier>DOI: 10.1002/gps.5503</identifier><identifier>PMID: 33527441</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Alzheimer's disease ; Atrophy ; Cognitive ability ; Cortex (parietal) ; Dementia ; Dementia disorders ; episodic memory ; Frontotemporal dementia ; Geriatric psychiatry ; gray matter ; Magnetic resonance imaging ; Memory ; Neurodegenerative diseases ; neuroimaging ; Parahippocampal gyrus ; Patients ; Substantia grisea ; Temporal cortex ; Temporal gyrus ; Temporal lobe</subject><ispartof>International journal of geriatric psychiatry, 2021-12, Vol.36 (12), p.1848-1857</ispartof><rights>2021 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3833-7f79daf1bd5ea947ab6a1fd8b4aa979469e27d70bc75265d55ce9d14a6e71f173</citedby><cites>FETCH-LOGICAL-c3833-7f79daf1bd5ea947ab6a1fd8b4aa979469e27d70bc75265d55ce9d14a6e71f173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fgps.5503$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fgps.5503$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33527441$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Resende, Elisa de Paula França</creatorcontrib><creatorcontrib>Hornberger, Michael</creatorcontrib><creatorcontrib>Guimarães, Henrique Cerqueira</creatorcontrib><creatorcontrib>Gambogi, Leandro Boson</creatorcontrib><creatorcontrib>Mariano, Luciano Inácio</creatorcontrib><creatorcontrib>Teixeira, Antônio Lúcio</creatorcontrib><creatorcontrib>Caramelli, Paulo</creatorcontrib><creatorcontrib>Cruz de Souza, Leonardo</creatorcontrib><title>Different patterns of gray matter atrophy in behavioral variant frontotemporal dementia with and without episodic memory impairment</title><title>International journal of geriatric psychiatry</title><addtitle>Int J Geriatr Psychiatry</addtitle><description>Background
Differentiating patients with behavioral variant frontotemporal dementia (bvFTD) from Alzheimer's disease (AD) is important as these two conditions have distinct treatment and prognosis. Using episodic impairment and medial temporal lobe atrophy as a tool to make this distinction has been debatable in the recent literature, as some patients with bvFTD can also have episodic memory impairment and medial temporal lobe atrophy early in the disease.
Objectives
To compare brain atrophy patterns of patients with bvFTD with and without episodic memory impairment to that of patients with AD.
Methods
We analyzed 19 patients with bvFTD, 21 with AD and 21 controls, matched by age, sex, and years of education. They underwent brain MRI and the memory test from the Brief Cognitive Battery (BCB) to assess episodic memory. We then categorized the bvFTD group into amnestic (BCB delayed recall score <7) and non‐amnestic.
Results
The amnestic bvFTD group (n = 8) had significant gray matter atrophy in the left parahippocampal gyrus, right cingulate and precuneus regions compared with the nonamnestic group. Compared with AD, amnestic bvFTD had more atrophy in the left fusiform cortex, left insula, left inferior temporal gyrus and right temporal pole, whereas patients with AD had more atrophy in the left hippocampus, left frontal pole and left angular gyrus.
Conclusions
There is a group of amnestic bvFTD patients with episodic memory dysfunction and significant atrophy in medial temporal structures, which poses a challenge in considering only these features when differentiating bvFTD from AD clinically.
Key Points
Patients with behavioral variant Frontotemporal dementia can have impairment in visual episodic memory with temporal lobe atrophy, even when compared with patients with amnestic Alzheimer's disease</description><subject>Alzheimer's disease</subject><subject>Atrophy</subject><subject>Cognitive ability</subject><subject>Cortex (parietal)</subject><subject>Dementia</subject><subject>Dementia disorders</subject><subject>episodic memory</subject><subject>Frontotemporal dementia</subject><subject>Geriatric psychiatry</subject><subject>gray matter</subject><subject>Magnetic resonance imaging</subject><subject>Memory</subject><subject>Neurodegenerative diseases</subject><subject>neuroimaging</subject><subject>Parahippocampal gyrus</subject><subject>Patients</subject><subject>Substantia grisea</subject><subject>Temporal cortex</subject><subject>Temporal gyrus</subject><subject>Temporal lobe</subject><issn>0885-6230</issn><issn>1099-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kUFrFTEQx4NY7LMKfgIJePGybbK7STZHabUKhQrqOcxuJn0pu5s1yba8s1_cvNeqIPQ0w8xvfgz8CXnD2SlnrD67WdKpEKx5RjacaV1xLuVzsmFdJypZN-yYvEzplrGy490Lctw0olZtyzfk14V3DiPOmS6QM8Y50eDoTYQdnQ4DCjmGZbujfqY9buHOhwgjvYPooVy5GOYcMk7LYWxxKi4P9N7nLYXZHpqwZoqLT8H6gU44hVh00wI-7ulX5MjBmPD1Yz0hPz59_H7-ubq6vvxy_uGqGpquaSrllLbgeG8Fgm4V9BK4s13fAmilW6mxVlaxflCilsIKMaC2vAWJijuumhPy_sG7xPBzxZTN5NOA4wgzhjWZuu2E4LLWsqDv_kNvwxrn8p2phWZa6rYR_4RDDClFdGaJfoK4M5yZfTCmBGP2wRT07aNw7Se0f8E_SRSgegDu_Yi7J0Xm8uu3g_A3Gn2aQw</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Resende, Elisa de Paula França</creator><creator>Hornberger, Michael</creator><creator>Guimarães, Henrique Cerqueira</creator><creator>Gambogi, Leandro Boson</creator><creator>Mariano, Luciano Inácio</creator><creator>Teixeira, Antônio Lúcio</creator><creator>Caramelli, Paulo</creator><creator>Cruz de Souza, Leonardo</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>202112</creationdate><title>Different patterns of gray matter atrophy in behavioral variant frontotemporal dementia with and without episodic memory impairment</title><author>Resende, Elisa de Paula França ; Hornberger, Michael ; Guimarães, Henrique Cerqueira ; Gambogi, Leandro Boson ; Mariano, Luciano Inácio ; Teixeira, Antônio Lúcio ; Caramelli, Paulo ; Cruz de Souza, Leonardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3833-7f79daf1bd5ea947ab6a1fd8b4aa979469e27d70bc75265d55ce9d14a6e71f173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Alzheimer's disease</topic><topic>Atrophy</topic><topic>Cognitive ability</topic><topic>Cortex (parietal)</topic><topic>Dementia</topic><topic>Dementia disorders</topic><topic>episodic memory</topic><topic>Frontotemporal dementia</topic><topic>Geriatric psychiatry</topic><topic>gray matter</topic><topic>Magnetic resonance imaging</topic><topic>Memory</topic><topic>Neurodegenerative diseases</topic><topic>neuroimaging</topic><topic>Parahippocampal gyrus</topic><topic>Patients</topic><topic>Substantia grisea</topic><topic>Temporal cortex</topic><topic>Temporal gyrus</topic><topic>Temporal lobe</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Resende, Elisa de Paula França</creatorcontrib><creatorcontrib>Hornberger, Michael</creatorcontrib><creatorcontrib>Guimarães, Henrique Cerqueira</creatorcontrib><creatorcontrib>Gambogi, Leandro Boson</creatorcontrib><creatorcontrib>Mariano, Luciano Inácio</creatorcontrib><creatorcontrib>Teixeira, Antônio Lúcio</creatorcontrib><creatorcontrib>Caramelli, Paulo</creatorcontrib><creatorcontrib>Cruz de Souza, Leonardo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of geriatric psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Resende, Elisa de Paula França</au><au>Hornberger, Michael</au><au>Guimarães, Henrique Cerqueira</au><au>Gambogi, Leandro Boson</au><au>Mariano, Luciano Inácio</au><au>Teixeira, Antônio Lúcio</au><au>Caramelli, Paulo</au><au>Cruz de Souza, Leonardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Different patterns of gray matter atrophy in behavioral variant frontotemporal dementia with and without episodic memory impairment</atitle><jtitle>International journal of geriatric psychiatry</jtitle><addtitle>Int J Geriatr Psychiatry</addtitle><date>2021-12</date><risdate>2021</risdate><volume>36</volume><issue>12</issue><spage>1848</spage><epage>1857</epage><pages>1848-1857</pages><issn>0885-6230</issn><eissn>1099-1166</eissn><abstract>Background
Differentiating patients with behavioral variant frontotemporal dementia (bvFTD) from Alzheimer's disease (AD) is important as these two conditions have distinct treatment and prognosis. Using episodic impairment and medial temporal lobe atrophy as a tool to make this distinction has been debatable in the recent literature, as some patients with bvFTD can also have episodic memory impairment and medial temporal lobe atrophy early in the disease.
Objectives
To compare brain atrophy patterns of patients with bvFTD with and without episodic memory impairment to that of patients with AD.
Methods
We analyzed 19 patients with bvFTD, 21 with AD and 21 controls, matched by age, sex, and years of education. They underwent brain MRI and the memory test from the Brief Cognitive Battery (BCB) to assess episodic memory. We then categorized the bvFTD group into amnestic (BCB delayed recall score <7) and non‐amnestic.
Results
The amnestic bvFTD group (n = 8) had significant gray matter atrophy in the left parahippocampal gyrus, right cingulate and precuneus regions compared with the nonamnestic group. Compared with AD, amnestic bvFTD had more atrophy in the left fusiform cortex, left insula, left inferior temporal gyrus and right temporal pole, whereas patients with AD had more atrophy in the left hippocampus, left frontal pole and left angular gyrus.
Conclusions
There is a group of amnestic bvFTD patients with episodic memory dysfunction and significant atrophy in medial temporal structures, which poses a challenge in considering only these features when differentiating bvFTD from AD clinically.
Key Points
Patients with behavioral variant Frontotemporal dementia can have impairment in visual episodic memory with temporal lobe atrophy, even when compared with patients with amnestic Alzheimer's disease</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33527441</pmid><doi>10.1002/gps.5503</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0885-6230 |
| ispartof | International journal of geriatric psychiatry, 2021-12, Vol.36 (12), p.1848-1857 |
| issn | 0885-6230 1099-1166 |
| language | eng |
| recordid | cdi_pubmed_primary_33527441 |
| source | Wiley Online Library |
| subjects | Alzheimer's disease Atrophy Cognitive ability Cortex (parietal) Dementia Dementia disorders episodic memory Frontotemporal dementia Geriatric psychiatry gray matter Magnetic resonance imaging Memory Neurodegenerative diseases neuroimaging Parahippocampal gyrus Patients Substantia grisea Temporal cortex Temporal gyrus Temporal lobe |
| title | Different patterns of gray matter atrophy in behavioral variant frontotemporal dementia with and without episodic memory impairment |
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