Genetic analysis of amyotrophic lateral sclerosis identifies contributing pathways and cell types

Despite the considerable progress in unraveling the genetic causes of amyotrophic lateral sclerosis (ALS), we do not fully understand the molecular mechanisms underlying the disease. We analyzed genome-wide data involving 78,500 individuals using a polygenic risk score approach to identify the biolo...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Science advances 2021-01, Vol.7 (3), Article 9036
Hauptverfasser:	Saez-Atienzar, Sara, Bandres-Ciga, Sara, Langston, Rebekah G., Kim, Jonggeol J., Choi, Shing Wan, Reynolds, Regina H., Abramzon, Yevgeniya, Dewan, Ramita, Ahmed, Sarah, Landers, John E., Chia, Ruth, Ryten, Mina, Cookson, Mark R., Nalls, Michael A., Chio, Adriano, Traynor, Bryan J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic Lateral Sclerosis - genetics Genetic Testing Genetics Genome-Wide Association Study Humans Multidisciplinary Sciences Neuroscience Polymorphism, Single Nucleotide SciAdv r-articles Science & Technology Science & Technology - Other Topics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!