Antifibrotic effect of novel neutrophil gelatinase-associated lipocalin inhibitors in cardiac and renal disease models

Neutrophil gelatinase-associated lipocalin (NGAL) is involved in cardiovascular and renal diseases. Gene inactivation of NGAL blunts the pathophysiological consequences of cardiovascular and renal damage. We aimed to design chemical NGAL inhibitors and investigate its effects in experimental models...

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Veröffentlicht in:	Scientific reports 2021-01, Vol.11 (1), p.2591-11, Article 2591
Hauptverfasser:	Bonnard, Benjamin, Martínez-Martínez, Ernesto, Fernández-Celis, Amaya, Pieronne-Deperrois, Marie, Do, Quoc-Tuan, Ramos, Isbaal, Rossignol, Patrick, Zannad, Faiez, Mulder, Paul, Ouvrard-Pascaud, Antoine, López-Andrés, Natalia, Jaisser, Frédéric
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154 631/154/1435 631/154/556 Blood pressure Coronary artery disease Fibroblasts Fibrosis Gelatinase Heart diseases Humanities and Social Sciences Inactivation Inflammation Inhibitors Kidney diseases Kidneys Leukocytes (neutrophilic) Life Sciences Lipocalin Metabolic disorders multidisciplinary Multidisciplinary Sciences Myocardial infarction Nephrectomy Neutrophils Renal function Science Science & Technology Science & Technology - Other Topics Science (multidisciplinary)
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