The nephrotoxicity of T-2 toxin in mice caused by oxidative stress-mediated apoptosis is related to Nrf2 pathway
T-2 toxin is an inevitable environmental and grain pollutant, which can cause kidney damage, but the mechanism is not clear. In this study, male mice were administered with T-2 toxin at 0, 0.5, 1.0, 2.0 mg/kg body weight (BW) for 28 days. We found that T-2 toxin induced renal structural damage, down...
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| Veröffentlicht in: | Food and chemical toxicology 2021-03, Vol.149, p.112027, Article 112027 |
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| creator | Zhang, Xuliang Wang, Yucong Yang, Xu Liu, Menglin Huang, Wanyue Zhang, Jian Song, Miao Shao, Bing Li, Yanfei |
| description | T-2 toxin is an inevitable environmental and grain pollutant, which can cause kidney damage, but the mechanism is not clear. In this study, male mice were administered with T-2 toxin at 0, 0.5, 1.0, 2.0 mg/kg body weight (BW) for 28 days. We found that T-2 toxin induced renal structural damage, downregulated BW and kidney coefficient, impaired renal function accompanied by oxidative stress and apoptosis. Meanwhile, T-2 toxin increased nuclear Nrf2 protein expression and the mRNA expressions of its downstream target genes. The correlation analysis indicated that apoptosis and Nrf2 pathway were positively correlated with oxidative stress. These results suggested that the nephrotoxicity of T-2 toxin in mice caused by oxidative stress-mediated apoptosis is related to Nrf2 pathway.
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| doi_str_mv | 10.1016/j.fct.2021.112027 |
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[Display omitted]</description><subject>Apoptosis</subject><subject>Food Science & Technology</subject><subject>Life Sciences & Biomedicine</subject><subject>Nephrotoxicity</subject><subject>Nrf2 pathway</subject><subject>Oxidative stress</subject><subject>Science & Technology</subject><subject>T-2 toxin</subject><subject>Toxicology</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><recordid>eNqNkE9LxDAQxYMouq5-AC-Su3RNmjZt8SSL_0D0sp5Lkk7YLG5Tkqy6395Zqx5FeDDJzHsh8yPkjLMZZ1xermbWpFnOcj7jHEu1Rya8rkQmRcn3yQQ7dSYbXh6R4xhXjLGKV_KQHAlRsrrgckKGxRJoD8My-OQ_nHFpS72liyynu3tPUWtngBq1idBRjeMP16nk3oDGFCDGbA2dUwmHavBD8tFFigrw-tVMnj4Fm9NBpeW72p6QA6teI5x-1yl5ub1ZzO-zx-e7h_n1Y2ZEKVImobCs1nUnQVuQDWtYqY21tm4qpmWhdVmUokIV0Kg8r5TuWKFlIzjYRhsxJXx81wQfYwDbDsGtVdi2nLU7eu2qRXrtjl470sPM-ZgZNhqX-k384EJDPRreQXsbjYPewK8N-UqR56WUeBJ87hJi8v3cb_qE0Yv_R9F9NboBEb05CO13onMB8Nedd3_s8QkAz6HW</recordid><startdate>202103</startdate><enddate>202103</enddate><creator>Zhang, Xuliang</creator><creator>Wang, Yucong</creator><creator>Yang, Xu</creator><creator>Liu, Menglin</creator><creator>Huang, Wanyue</creator><creator>Zhang, Jian</creator><creator>Song, Miao</creator><creator>Shao, Bing</creator><creator>Li, Yanfei</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-5740-9945</orcidid></search><sort><creationdate>202103</creationdate><title>The nephrotoxicity of T-2 toxin in mice caused by oxidative stress-mediated apoptosis is related to Nrf2 pathway</title><author>Zhang, Xuliang ; Wang, Yucong ; Yang, Xu ; Liu, Menglin ; Huang, Wanyue ; Zhang, Jian ; Song, Miao ; Shao, Bing ; Li, Yanfei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-6e4f08b8d6ebfe690905bcfff8970b64bb545375374e9a227abd04b6931ef9bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Apoptosis</topic><topic>Food Science & Technology</topic><topic>Life Sciences & Biomedicine</topic><topic>Nephrotoxicity</topic><topic>Nrf2 pathway</topic><topic>Oxidative stress</topic><topic>Science & Technology</topic><topic>T-2 toxin</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Xuliang</creatorcontrib><creatorcontrib>Wang, Yucong</creatorcontrib><creatorcontrib>Yang, Xu</creatorcontrib><creatorcontrib>Liu, Menglin</creatorcontrib><creatorcontrib>Huang, Wanyue</creatorcontrib><creatorcontrib>Zhang, Jian</creatorcontrib><creatorcontrib>Song, Miao</creatorcontrib><creatorcontrib>Shao, Bing</creatorcontrib><creatorcontrib>Li, Yanfei</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Food and chemical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Xuliang</au><au>Wang, Yucong</au><au>Yang, Xu</au><au>Liu, Menglin</au><au>Huang, Wanyue</au><au>Zhang, Jian</au><au>Song, Miao</au><au>Shao, Bing</au><au>Li, Yanfei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The nephrotoxicity of T-2 toxin in mice caused by oxidative stress-mediated apoptosis is related to Nrf2 pathway</atitle><jtitle>Food and chemical toxicology</jtitle><stitle>FOOD CHEM TOXICOL</stitle><addtitle>Food Chem Toxicol</addtitle><date>2021-03</date><risdate>2021</risdate><volume>149</volume><spage>112027</spage><pages>112027-</pages><artnum>112027</artnum><issn>0278-6915</issn><eissn>1873-6351</eissn><abstract>T-2 toxin is an inevitable environmental and grain pollutant, which can cause kidney damage, but the mechanism is not clear. In this study, male mice were administered with T-2 toxin at 0, 0.5, 1.0, 2.0 mg/kg body weight (BW) for 28 days. We found that T-2 toxin induced renal structural damage, downregulated BW and kidney coefficient, impaired renal function accompanied by oxidative stress and apoptosis. Meanwhile, T-2 toxin increased nuclear Nrf2 protein expression and the mRNA expressions of its downstream target genes. The correlation analysis indicated that apoptosis and Nrf2 pathway were positively correlated with oxidative stress. These results suggested that the nephrotoxicity of T-2 toxin in mice caused by oxidative stress-mediated apoptosis is related to Nrf2 pathway.
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| identifier | ISSN: 0278-6915 |
| ispartof | Food and chemical toxicology, 2021-03, Vol.149, p.112027, Article 112027 |
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| source | ScienceDirect Journals (5 years ago - present); Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /> |
| subjects | Apoptosis Food Science & Technology Life Sciences & Biomedicine Nephrotoxicity Nrf2 pathway Oxidative stress Science & Technology T-2 toxin Toxicology |
| title | The nephrotoxicity of T-2 toxin in mice caused by oxidative stress-mediated apoptosis is related to Nrf2 pathway |
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