MiRNA-15b and miRNA-125b are associated with regional Aβ-PET and FDG-PET uptake in cognitively normal individuals with subjective memory complaints
There is substantial experimental evidence for dysregulation of several microRNA (miRNA) expression levels in Alzheimer’s disease (AD). MiRNAs modulate critical brain intracellular signaling pathways and are associated with AD core pathophysiological mechanisms. First, we conducted a real-time quant...
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| Veröffentlicht in: | Translational psychiatry 2021-01, Vol.11 (1), p.78-11, Article 78 |
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| creator | Vergallo, Andrea Lista, Simone Zhao, Yuhai Lemercier, Pablo Teipel, Stefan J. Potier, Marie-Claude Habert, Marie-Odile Dubois, Bruno Lukiw, Walter J. Hampel, Harald |
| description | There is substantial experimental evidence for dysregulation of several microRNA (miRNA) expression levels in Alzheimer’s disease (AD). MiRNAs modulate critical brain intracellular signaling pathways and are associated with AD core pathophysiological mechanisms. First, we conducted a real-time quantitative PCR-based pilot study to identify a set of brain-enriched miRNAs in a monocentric cohort of cognitively normal individuals with subjective memory complaints, a condition associated with increased risk of AD. Second, we investigated the impact of age, sex, and the Apolipoprotein E
ε4
(
APOE ε4
) allele, on the identified miRNA plasma concentrations. In addition, we explored the cross-sectional and longitudinal association of the miRNAs plasma concentrations with regional brain metabolic uptake using amyloid-β (Aβ)-positron emission tomography (Aβ-PET) and
18
F-fluorodeoxyglucose-PET (
18
F-FDG-PET). We identified a set of six brain-enriched miRNAs—miRNA-125b, miRNA-146a, miRNA-15b, miRNA-148a, miRNA-26b, and miRNA-100. Age, sex, and
APOE ε4
allele were not associated with individual miRNA abundance. MiRNA-15b concentrations were significantly lower in the Aβ-PET-positive compared to Aβ-PET-negative individuals. Furthermore, we found a positive effect of the miRNA-15b*time interaction on regional metabolic
18
F-FDG-PET uptake in the left hippocampus. Plasma miRNA-125b concentrations, as well as the miRNA-125b*time interaction (over a 2-year follow-up), were negatively associated with regional Aβ-PET standard uptake value ratio in the right anterior cingulate cortex. At baseline, we found a significantly negative association between plasma miRNA-125b concentrations and
18
F-FDG-PET uptake in specific brain regions. In an asymptomatic at-risk population for AD, we show significant associations between plasma concentrations of miRNA-125b and miRNA-15b with core neuroimaging biomarkers of AD pathophysiology. Our results, coupled with existing experimental evidence, suggest a potential protective anti-Aβ effect of miRNA-15b and a biological link between miRNA-125b and Aβ-independent neurotoxic pathways. |
| doi_str_mv | 10.1038/s41398-020-01184-8 |
| format | Article |
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ε4
(
APOE ε4
) allele, on the identified miRNA plasma concentrations. In addition, we explored the cross-sectional and longitudinal association of the miRNAs plasma concentrations with regional brain metabolic uptake using amyloid-β (Aβ)-positron emission tomography (Aβ-PET) and
18
F-fluorodeoxyglucose-PET (
18
F-FDG-PET). We identified a set of six brain-enriched miRNAs—miRNA-125b, miRNA-146a, miRNA-15b, miRNA-148a, miRNA-26b, and miRNA-100. Age, sex, and
APOE ε4
allele were not associated with individual miRNA abundance. MiRNA-15b concentrations were significantly lower in the Aβ-PET-positive compared to Aβ-PET-negative individuals. Furthermore, we found a positive effect of the miRNA-15b*time interaction on regional metabolic
18
F-FDG-PET uptake in the left hippocampus. Plasma miRNA-125b concentrations, as well as the miRNA-125b*time interaction (over a 2-year follow-up), were negatively associated with regional Aβ-PET standard uptake value ratio in the right anterior cingulate cortex. At baseline, we found a significantly negative association between plasma miRNA-125b concentrations and
18
F-FDG-PET uptake in specific brain regions. In an asymptomatic at-risk population for AD, we show significant associations between plasma concentrations of miRNA-125b and miRNA-15b with core neuroimaging biomarkers of AD pathophysiology. Our results, coupled with existing experimental evidence, suggest a potential protective anti-Aβ effect of miRNA-15b and a biological link between miRNA-125b and Aβ-independent neurotoxic pathways.</description><identifier>ISSN: 2158-3188</identifier><identifier>EISSN: 2158-3188</identifier><identifier>DOI: 10.1038/s41398-020-01184-8</identifier><identifier>PMID: 33504764</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>38/77 ; 59/78 ; 631/378/340 ; 692/53/2422 ; 692/53/2423 ; 692/699/476 ; Alzheimer Disease - diagnostic imaging ; Alzheimer Disease - genetics ; Amyloid beta-Peptides - metabolism ; Behavioral Sciences ; Biochemistry, Molecular Biology ; Biological Psychology ; Brain - diagnostic imaging ; Brain - metabolism ; Cognitive Sciences ; Cross-Sectional Studies ; Fluorodeoxyglucose F18 ; Genomics ; Humans ; Life Sciences ; Life Sciences & Biomedicine ; Medicine ; Medicine & Public Health ; Metabolism ; MicroRNAs ; MicroRNAs - genetics ; Neurobiology ; Neurons and Cognition ; Neurosciences ; Pharmacotherapy ; Pilot Projects ; Plasma ; Positron-Emission Tomography ; Psychiatry ; Science & Technology</subject><ispartof>Translational psychiatry, 2021-01, Vol.11 (1), p.78-11, Article 78</ispartof><rights>The Author(s) 2021</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>17</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000612361300001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c574t-2c5af2405d8350f4437d64b0959cee461d2b69b634e9e9e5735a7d63932d034e3</citedby><cites>FETCH-LOGICAL-c574t-2c5af2405d8350f4437d64b0959cee461d2b69b634e9e9e5735a7d63932d034e3</cites><orcidid>0000-0002-0208-6384 ; 0000-0001-6804-7858 ; 0000-0003-1722-8303 ; 0000-0003-0894-8982 ; 0000-0003-2462-7150 ; 0000-0002-7719-9746</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840941/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840941/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2106,2118,27933,27934,39267,41129,42198,51585,53800,53802</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33504764$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.sorbonne-universite.fr/hal-03125818$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Vergallo, Andrea</creatorcontrib><creatorcontrib>Lista, Simone</creatorcontrib><creatorcontrib>Zhao, Yuhai</creatorcontrib><creatorcontrib>Lemercier, Pablo</creatorcontrib><creatorcontrib>Teipel, Stefan J.</creatorcontrib><creatorcontrib>Potier, Marie-Claude</creatorcontrib><creatorcontrib>Habert, Marie-Odile</creatorcontrib><creatorcontrib>Dubois, Bruno</creatorcontrib><creatorcontrib>Lukiw, Walter J.</creatorcontrib><creatorcontrib>Hampel, Harald</creatorcontrib><creatorcontrib>APMI</creatorcontrib><creatorcontrib>INSIGHT-preAD Study Grp</creatorcontrib><creatorcontrib>INSIGHT-preAD study group</creatorcontrib><creatorcontrib>Alzheimer Precision Medicine Initiative (APMI)</creatorcontrib><creatorcontrib>for the INSIGHT-preAD study group</creatorcontrib><creatorcontrib>the Alzheimer Precision Medicine Initiative (APMI)</creatorcontrib><title>MiRNA-15b and miRNA-125b are associated with regional Aβ-PET and FDG-PET uptake in cognitively normal individuals with subjective memory complaints</title><title>Translational psychiatry</title><addtitle>Transl Psychiatry</addtitle><addtitle>TRANSL PSYCHIAT</addtitle><addtitle>Transl Psychiatry</addtitle><description>There is substantial experimental evidence for dysregulation of several microRNA (miRNA) expression levels in Alzheimer’s disease (AD). MiRNAs modulate critical brain intracellular signaling pathways and are associated with AD core pathophysiological mechanisms. First, we conducted a real-time quantitative PCR-based pilot study to identify a set of brain-enriched miRNAs in a monocentric cohort of cognitively normal individuals with subjective memory complaints, a condition associated with increased risk of AD. Second, we investigated the impact of age, sex, and the Apolipoprotein E
ε4
(
APOE ε4
) allele, on the identified miRNA plasma concentrations. In addition, we explored the cross-sectional and longitudinal association of the miRNAs plasma concentrations with regional brain metabolic uptake using amyloid-β (Aβ)-positron emission tomography (Aβ-PET) and
18
F-fluorodeoxyglucose-PET (
18
F-FDG-PET). We identified a set of six brain-enriched miRNAs—miRNA-125b, miRNA-146a, miRNA-15b, miRNA-148a, miRNA-26b, and miRNA-100. Age, sex, and
APOE ε4
allele were not associated with individual miRNA abundance. MiRNA-15b concentrations were significantly lower in the Aβ-PET-positive compared to Aβ-PET-negative individuals. Furthermore, we found a positive effect of the miRNA-15b*time interaction on regional metabolic
18
F-FDG-PET uptake in the left hippocampus. Plasma miRNA-125b concentrations, as well as the miRNA-125b*time interaction (over a 2-year follow-up), were negatively associated with regional Aβ-PET standard uptake value ratio in the right anterior cingulate cortex. At baseline, we found a significantly negative association between plasma miRNA-125b concentrations and
18
F-FDG-PET uptake in specific brain regions. In an asymptomatic at-risk population for AD, we show significant associations between plasma concentrations of miRNA-125b and miRNA-15b with core neuroimaging biomarkers of AD pathophysiology. Our results, coupled with existing experimental evidence, suggest a potential protective anti-Aβ effect of miRNA-15b and a biological link between miRNA-125b and Aβ-independent neurotoxic pathways.</description><subject>38/77</subject><subject>59/78</subject><subject>631/378/340</subject><subject>692/53/2422</subject><subject>692/53/2423</subject><subject>692/699/476</subject><subject>Alzheimer Disease - diagnostic imaging</subject><subject>Alzheimer Disease - genetics</subject><subject>Amyloid beta-Peptides - metabolism</subject><subject>Behavioral Sciences</subject><subject>Biochemistry, Molecular Biology</subject><subject>Biological Psychology</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - metabolism</subject><subject>Cognitive Sciences</subject><subject>Cross-Sectional Studies</subject><subject>Fluorodeoxyglucose F18</subject><subject>Genomics</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Life Sciences & Biomedicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolism</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>Neurobiology</subject><subject>Neurons and Cognition</subject><subject>Neurosciences</subject><subject>Pharmacotherapy</subject><subject>Pilot Projects</subject><subject>Plasma</subject><subject>Positron-Emission Tomography</subject><subject>Psychiatry</subject><subject>Science & Technology</subject><issn>2158-3188</issn><issn>2158-3188</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNqNkstu1DAUhiMEotXQF2CBIrFCKGDHduJskEZDb9JwESpry7dMPST21HammvfgSXgQnglnUoaWBSJZxD75_t8-On-WPYfgDQSIvg0YooYWoAQFgJDigj7KjktIaIEgpY_vrY-ykxDWID0EU1jDp9kRQgTgusLH2fcP5svHeQGJyLlVeT_tynHrdc5DcNLwqFV-a-J17vXKOMu7fP7zR_H59GqvOXt_vl8Pm8i_6dzYXLqVNdFsdbfLrfN9EhirzNaogXdhsgqDWGs5Qnmve-d3SdVvOm5sDM-yJ20C9cndd5Z9PTu9WlwUy0_nl4v5spCkxrEoJeFtiQFRNPXTYoxqVWEBGtJIrXEFVSmqRlQI6ya9pEaEJwI1qFQgFdEsu5x8leNrtvGm537HHDdsX3B-xbiPRnaaYSIA4aCuOeZYIkzLBmkhWi6FEgq2yevd5LUZRK-V1DZ63j0wffjHmmu2cltWUwyaNMxZ9moyuP5LdjFfsrEGUJoLhXQ7si_vDvPuZtAhsrUbfBpMYCWmoGmqhCaqnCjpXQhetwdbCNgYIjaFiKUQsX2IGE2iF_f7OEh-RyYBryfgVgvXBmm0lfqApZSls1EF0Ri48ab0_-mFiTymgC3cYGOSokkaEm5X2v9p8h_3_wXC6_LC</recordid><startdate>20210127</startdate><enddate>20210127</enddate><creator>Vergallo, Andrea</creator><creator>Lista, Simone</creator><creator>Zhao, Yuhai</creator><creator>Lemercier, Pablo</creator><creator>Teipel, Stefan J.</creator><creator>Potier, Marie-Claude</creator><creator>Habert, Marie-Odile</creator><creator>Dubois, Bruno</creator><creator>Lukiw, Walter J.</creator><creator>Hampel, Harald</creator><general>Nature Publishing Group UK</general><general>Springer Nature</general><general>Nature Publishing Group</general><general>Nature Pub. 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diagnostic imaging</topic><topic>Alzheimer Disease - genetics</topic><topic>Amyloid beta-Peptides - metabolism</topic><topic>Behavioral Sciences</topic><topic>Biochemistry, Molecular Biology</topic><topic>Biological Psychology</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - metabolism</topic><topic>Cognitive Sciences</topic><topic>Cross-Sectional Studies</topic><topic>Fluorodeoxyglucose F18</topic><topic>Genomics</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Life Sciences & Biomedicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolism</topic><topic>MicroRNAs</topic><topic>MicroRNAs - genetics</topic><topic>Neurobiology</topic><topic>Neurons and Cognition</topic><topic>Neurosciences</topic><topic>Pharmacotherapy</topic><topic>Pilot Projects</topic><topic>Plasma</topic><topic>Positron-Emission Tomography</topic><topic>Psychiatry</topic><topic>Science & Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vergallo, Andrea</creatorcontrib><creatorcontrib>Lista, Simone</creatorcontrib><creatorcontrib>Zhao, Yuhai</creatorcontrib><creatorcontrib>Lemercier, Pablo</creatorcontrib><creatorcontrib>Teipel, Stefan J.</creatorcontrib><creatorcontrib>Potier, Marie-Claude</creatorcontrib><creatorcontrib>Habert, Marie-Odile</creatorcontrib><creatorcontrib>Dubois, Bruno</creatorcontrib><creatorcontrib>Lukiw, Walter J.</creatorcontrib><creatorcontrib>Hampel, Harald</creatorcontrib><creatorcontrib>APMI</creatorcontrib><creatorcontrib>INSIGHT-preAD Study Grp</creatorcontrib><creatorcontrib>INSIGHT-preAD study group</creatorcontrib><creatorcontrib>Alzheimer Precision Medicine Initiative (APMI)</creatorcontrib><creatorcontrib>for the INSIGHT-preAD study group</creatorcontrib><creatorcontrib>the Alzheimer Precision Medicine Initiative (APMI)</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Translational psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vergallo, Andrea</au><au>Lista, Simone</au><au>Zhao, Yuhai</au><au>Lemercier, Pablo</au><au>Teipel, Stefan J.</au><au>Potier, Marie-Claude</au><au>Habert, Marie-Odile</au><au>Dubois, Bruno</au><au>Lukiw, Walter J.</au><au>Hampel, Harald</au><aucorp>APMI</aucorp><aucorp>INSIGHT-preAD Study Grp</aucorp><aucorp>INSIGHT-preAD study group</aucorp><aucorp>Alzheimer Precision Medicine Initiative (APMI)</aucorp><aucorp>for the INSIGHT-preAD study group</aucorp><aucorp>the Alzheimer Precision Medicine Initiative (APMI)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MiRNA-15b and miRNA-125b are associated with regional Aβ-PET and FDG-PET uptake in cognitively normal individuals with subjective memory complaints</atitle><jtitle>Translational psychiatry</jtitle><stitle>Transl Psychiatry</stitle><stitle>TRANSL PSYCHIAT</stitle><addtitle>Transl Psychiatry</addtitle><date>2021-01-27</date><risdate>2021</risdate><volume>11</volume><issue>1</issue><spage>78</spage><epage>11</epage><pages>78-11</pages><artnum>78</artnum><issn>2158-3188</issn><eissn>2158-3188</eissn><abstract>There is substantial experimental evidence for dysregulation of several microRNA (miRNA) expression levels in Alzheimer’s disease (AD). MiRNAs modulate critical brain intracellular signaling pathways and are associated with AD core pathophysiological mechanisms. First, we conducted a real-time quantitative PCR-based pilot study to identify a set of brain-enriched miRNAs in a monocentric cohort of cognitively normal individuals with subjective memory complaints, a condition associated with increased risk of AD. Second, we investigated the impact of age, sex, and the Apolipoprotein E
ε4
(
APOE ε4
) allele, on the identified miRNA plasma concentrations. In addition, we explored the cross-sectional and longitudinal association of the miRNAs plasma concentrations with regional brain metabolic uptake using amyloid-β (Aβ)-positron emission tomography (Aβ-PET) and
18
F-fluorodeoxyglucose-PET (
18
F-FDG-PET). We identified a set of six brain-enriched miRNAs—miRNA-125b, miRNA-146a, miRNA-15b, miRNA-148a, miRNA-26b, and miRNA-100. Age, sex, and
APOE ε4
allele were not associated with individual miRNA abundance. MiRNA-15b concentrations were significantly lower in the Aβ-PET-positive compared to Aβ-PET-negative individuals. Furthermore, we found a positive effect of the miRNA-15b*time interaction on regional metabolic
18
F-FDG-PET uptake in the left hippocampus. Plasma miRNA-125b concentrations, as well as the miRNA-125b*time interaction (over a 2-year follow-up), were negatively associated with regional Aβ-PET standard uptake value ratio in the right anterior cingulate cortex. At baseline, we found a significantly negative association between plasma miRNA-125b concentrations and
18
F-FDG-PET uptake in specific brain regions. In an asymptomatic at-risk population for AD, we show significant associations between plasma concentrations of miRNA-125b and miRNA-15b with core neuroimaging biomarkers of AD pathophysiology. Our results, coupled with existing experimental evidence, suggest a potential protective anti-Aβ effect of miRNA-15b and a biological link between miRNA-125b and Aβ-independent neurotoxic pathways.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33504764</pmid><doi>10.1038/s41398-020-01184-8</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-0208-6384</orcidid><orcidid>https://orcid.org/0000-0001-6804-7858</orcidid><orcidid>https://orcid.org/0000-0003-1722-8303</orcidid><orcidid>https://orcid.org/0000-0003-0894-8982</orcidid><orcidid>https://orcid.org/0000-0003-2462-7150</orcidid><orcidid>https://orcid.org/0000-0002-7719-9746</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2158-3188 |
| ispartof | Translational psychiatry, 2021-01, Vol.11 (1), p.78-11, Article 78 |
| issn | 2158-3188 2158-3188 |
| language | eng |
| recordid | cdi_pubmed_primary_33504764 |
| source | MEDLINE; Nature Free; DOAJ Directory of Open Access Journals; Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; EZB-FREE-00999 freely available EZB journals; PubMed Central; Springer Nature OA/Free Journals |
| subjects | 38/77 59/78 631/378/340 692/53/2422 692/53/2423 692/699/476 Alzheimer Disease - diagnostic imaging Alzheimer Disease - genetics Amyloid beta-Peptides - metabolism Behavioral Sciences Biochemistry, Molecular Biology Biological Psychology Brain - diagnostic imaging Brain - metabolism Cognitive Sciences Cross-Sectional Studies Fluorodeoxyglucose F18 Genomics Humans Life Sciences Life Sciences & Biomedicine Medicine Medicine & Public Health Metabolism MicroRNAs MicroRNAs - genetics Neurobiology Neurons and Cognition Neurosciences Pharmacotherapy Pilot Projects Plasma Positron-Emission Tomography Psychiatry Science & Technology |
| title | MiRNA-15b and miRNA-125b are associated with regional Aβ-PET and FDG-PET uptake in cognitively normal individuals with subjective memory complaints |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-11-29T23%3A51%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=MiRNA-15b%20and%20miRNA-125b%20are%20associated%20with%20regional%20A%CE%B2-PET%20and%20FDG-PET%20uptake%20in%20cognitively%20normal%20individuals%20with%20subjective%20memory%20complaints&rft.jtitle=Translational%20psychiatry&rft.au=Vergallo,%20Andrea&rft.aucorp=APMI&rft.date=2021-01-27&rft.volume=11&rft.issue=1&rft.spage=78&rft.epage=11&rft.pages=78-11&rft.artnum=78&rft.issn=2158-3188&rft.eissn=2158-3188&rft_id=info:doi/10.1038/s41398-020-01184-8&rft_dat=%3Cproquest_pubme%3E2480996125%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2480996125&rft_id=info:pmid/33504764&rft_doaj_id=oai_doaj_org_article_45b05a077a4a4c348293ebbfacbdbd1f&rfr_iscdi=true |