Clinical analysis and pluripotent stem cells-based model reveal possible impacts of ACE2 and lung progenitor cells on infants vulnerable to COVID-19

An increasing number of children with severe coronavirus disease 2019 (COVID-19) is being reported, yet the spectrum of disease severity and expression patterns of angiotensin-converting enzyme 2 (ACE2) in children at different developmental stages are largely unknow. We analysed clinical features i...

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Veröffentlicht in:	Theranostics 2021, Vol.11 (5), p.2170-2181
Hauptverfasser:	Zhang, Zhao, Guo, Liyan, Lu, Xiaoxia, Zhang, Che, Huang, Li, Wang, Xianfeng, Duan, Fuyu, Liang, Huiying, Chen, Peikai, Zeng, Liang, Shao, Jianbo, Li, Hui, Li, Le, Liu, Li, Li, Cheng, Zhang, Jinqiu, Ma, Chui Yan, Kwan, Ka Yi, Liu, Wei, Xu, Yi, Gu, Xiaoqiong, Jiang, Hua, Du, Hui, Zhang, Ting, Wu, Yanheng, Yu, Guangyin, Chen, Junhui, Luo, Ruibang, Liao, Can, Tse, Hung-Fat, Chen, Zhiwei, Chen, Huanhuan Joyce, Xia, Huimin, Lian, Qizhou
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Angiotensin-Converting Enzyme 2 - metabolism Antibodies Biopsy Child Child, Preschool Children & youth Coronaviruses COVID-19 COVID-19 - pathology Disease transmission Female Genes Genomics Hospitals Humans Immune System Infant Infant, Newborn Infections Laboratories Lung - cytology Lung - virology Lungs Male Mortality Pediatrics Pneumonia Proteins Research Paper Risk Factors RNA-Seq SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Single-Cell Analysis SOX9 Transcription Factor - metabolism Stem cells Stem Cells - metabolism Stem Cells - virology Viral infections
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