17β-Estradiol and estrogen receptor α protect right ventricular function in pulmonary hypertension via BMPR2 and apelin

Women with pulmonary arterial hypertension (PAH) exhibit better right ventricular (RV) function and survival than men; however, the underlying mechanisms are unknown. We hypothesized that 17β-estradiol (E2), through estrogen receptor α (ER-α), attenuates PAH-induced RV failure (RVF) by upregulating...

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Veröffentlicht in:The Journal of clinical investigation 2021-03, Vol.131 (6), p.1-22
Hauptverfasser: Frump, Andrea L, Albrecht, Marjorie, Yakubov, Bakhtiyor, Breuils-Bonnet, Sandra, Nadeau, Valérie, Tremblay, Eve, Potus, Francois, Omura, Junichi, Cook, Todd, Fisher, Amanda, Rodriguez, Brooke, Brown, R Dale, Stenmark, Kurt R, Rubinstein, C Dustin, Krentz, Kathy, Tabima, Diana M, Li, Rongbo, Sun, Xin, Chesler, Naomi C, Provencher, Steeve, Bonnet, Sebastien, Lahm, Tim
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Sprache:eng
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