Depletion of Trp53 and Cdkn2a Does Not Promote Self-Renewal in the Mammary Gland but Amplifies Proliferation Induced by TNF-α

The mammary epithelium undergoes several rounds of extensive proliferation during the female reproductive cycle. Its expansion is a tightly regulated process, fueled by the mammary stem cells and these cells' unique property of self-renewal. Sufficient new cells have to be produced to maintain...

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Veröffentlicht in:	Stem cell reports 2021-02, Vol.16 (2), p.228-236
Hauptverfasser:	van Weele, Linda J., Scheeren, Ferenc A., Cai, Shang, Kuo, Angera H., Qian, Dalong, Ho, William H.D., Clarke, Michael F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell & Tissue Engineering Cell Biology Life Sciences & Biomedicine mammary gland epithelium mouse models p16 p19 p53 proliferation Science & Technology self-renewal TNF-α
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