Systemic Metabolic Alterations Correlate with Islet-Level Prostaglandin E-2 Production and Signaling Mechanisms That Predict beta-Cell Dysfunction in a Mouse Model of Type 2 Diabetes

The transition from beta-cell compensation to beta-cell failure is not well understood. Previous works by our group and others have demonstrated a role for Prostaglandin EP3 receptor (EP3), encoded by the Ptger3 gene, in the loss of functional beta-cell mass in Type 2 diabetes (T2D). The primary end...

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Veröffentlicht in:	Metabolites 2021-01, Vol.11 (1), Article 58
Hauptverfasser:	Schaid, Michael D., Zhu, Yanlong, Richardson, Nicole E., Patibandla, Chinmai, Ong, Irene M., Fenske, Rachel J., Neuman, Joshua C., Guthery, Erin, Reuter, Austin, Sandhu, Harpreet K., Fuller, Miles H., Cox, Elizabeth D., Davis, Dawn B., Layden, Brian T., Brasier, Allan R., Lamming, Dudley W., Ge, Ying, Kimple, Michelle E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry & Molecular Biology Life Sciences & Biomedicine Science & Technology
Online-Zugang:	Volltext
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