A human cancer cell line initiates DNA replication normally in the absence of ORC5 and ORC2 proteins
The origin recognition complex (ORC), composed of six subunits, ORC1-6, binds to origins of replication as a ring-shaped heterohexameric ATPase that is believed to be essential to recruit and load MCM2-7, the minichromosome maintenance protein complex, around DNA and initiate DNA replication. We pre...
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| Veröffentlicht in: | The Journal of biological chemistry 2020-12, Vol.295 (50), p.16949 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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