C-tag TNF: a reporter system to study TNF shedding

TNF is a highly pro-inflammatory cytokine that contributes not only to the regulation of immune responses but also to the development of severe inflammatory diseases. TNF is synthesized as a transmembrane protein, which is further matured via proteolytic cleavage by metalloproteases such as ADAM17,...

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Veröffentlicht in:	The Journal of biological chemistry 2020-12, Vol.295 (52), p.18065
Hauptverfasser:	Pinci, Francesca, Gaidt, Moritz M, Jung, Christophe, Kuut, Gunnar, Jackson, Margaret A, Bauernfried, Stefan, Hornung, Veit
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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