Tumor vasculature-targeted 10 B delivery by an Annexin A1-binding peptide boosts effects of boron neutron capture therapy

p-Boronophenylalanine ( BPA) is a powerful B drug used in current clinical trials of BNCT. For BNCT to be successful, a high (500 mg/kg) dose of BPA must be administered over a few hours. Here, we report BNCT efficacy after rapid, ultralow-dose administration of either tumor vasculature-specific ann...

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Veröffentlicht in:	BMC cancer 2021-01, Vol.21 (1), p.72
Hauptverfasser:	Yoneyama, Tohru, Hatakeyama, Shingo, Sutoh Yoneyama, Mihoko, Yoshiya, Taku, Uemura, Tsuyoshi, Ishizu, Takehiro, Suzuki, Minoru, Hachinohe, Shingo, Ishiyama, Shintaro, Nonaka, Motohiro, Fukuda, Michiko N, Ohyama, Chikara
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Annexin A1 - metabolism Apoptosis Boron Compounds - administration & dosage Boron Compounds - chemistry Boron Compounds - metabolism Boron Neutron Capture Therapy - methods Cell Proliferation Female Humans Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Nude Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Neovascularization, Pathologic - radiotherapy Peptide Fragments - metabolism Phenylalanine - administration & dosage Phenylalanine - analogs & derivatives Phenylalanine - chemistry Phenylalanine - metabolism Tumor Cells, Cultured Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - radiotherapy Xenograft Model Antitumor Assays
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