Type I interferons are essential while type II interferon is dispensable for protection against St. Louis encephalitis virus infection in the mouse brain

St. Louis encephalitis virus (SLEV) is a neglected mosquito-borne flavivirus that causes severe neurological disease in humans. SLEV replication in the central nervous system (CNS) induces the local production of interferons (IFNs), which are attributed to host protection. The antiviral response to...

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Veröffentlicht in:	Virulence 2021-12, Vol.12 (1), p.244-259
Hauptverfasser:	Rocha, Rebeca Froes, Del Sarto, Juliana L., Gomes, Giovanni F., Gonçalves, Mariana P., Rachid, Milene A., Smetana, Juliana H. C., Souza, Daniele G., Teixeira, Mauro Martins, Marques, Rafael Elias
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - immunology Brain - pathology Brain - virology Disease Models, Animal Encephalitis Virus, St. Louis - immunology Encephalitis, St. Louis - immunology flavivirus Immunology Infectious Diseases Interferon Type I - genetics Interferon Type I - immunology Interferon-gamma - genetics Interferon-gamma - immunology interferons Life Sciences & Biomedicine Mice Mice, Inbred C57BL Microbiology mouse model Neglected arbovirus Research Paper Science & Technology St. Louis encephalitis Viral Load Virus Replication - immunology
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