The App NL-G-F mouse retina is a site for preclinical Alzheimer's disease diagnosis and research

In this study, we report the results of a comprehensive phenotyping of the retina of the App mouse. We demonstrate that soluble Aβ accumulation is present in the retina of these mice early in life and progresses to Aβ plaque formation by midlife. This rising Aβ burden coincides with local microglia...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Acta neuropathologica communications 2021-01, Vol.9 (1), p.6
Hauptverfasser:	Vandenabeele, Marjan, Veys, Lien, Lemmens, Sophie, Hadoux, Xavier, Gelders, Géraldine, Masin, Luca, Serneels, Lutgarde, Theunis, Jan, Saito, Takashi, Saido, Takaomi C, Jayapala, Murali, De Boever, Patrick, De Strooper, Bart, Stalmans, Ingeborg, van Wijngaarden, Peter, Moons, Lieve, De Groef, Lies
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer Disease - physiopathology Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - genetics Animals Disease Progression Electroretinography Gliosis - metabolism Gliosis - pathology Hyperspectral Imaging Mice Mice, Transgenic Microglia - pathology Microglia - physiology Peptide Fragments - metabolism Phenotype Plaque, Amyloid - metabolism Plaque, Amyloid - pathology Plaque, Amyloid - physiopathology Retina - metabolism Retina - pathology Retina - physiopathology Retinal Neurons - physiology Retinal Vein - pathology Tomography, Optical Coherence
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!