The App NL-G-F mouse retina is a site for preclinical Alzheimer's disease diagnosis and research
In this study, we report the results of a comprehensive phenotyping of the retina of the App mouse. We demonstrate that soluble Aβ accumulation is present in the retina of these mice early in life and progresses to Aβ plaque formation by midlife. This rising Aβ burden coincides with local microglia...
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| Veröffentlicht in: | Acta neuropathologica communications 2021-01, Vol.9 (1), p.6 |
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| creator | Vandenabeele, Marjan Veys, Lien Lemmens, Sophie Hadoux, Xavier Gelders, Géraldine Masin, Luca Serneels, Lutgarde Theunis, Jan Saito, Takashi Saido, Takaomi C Jayapala, Murali De Boever, Patrick De Strooper, Bart Stalmans, Ingeborg van Wijngaarden, Peter Moons, Lieve De Groef, Lies |
| description | In this study, we report the results of a comprehensive phenotyping of the retina of the App
mouse. We demonstrate that soluble Aβ accumulation is present in the retina of these mice early in life and progresses to Aβ plaque formation by midlife. This rising Aβ burden coincides with local microglia reactivity, astrogliosis, and abnormalities in retinal vein morphology. Electrophysiological recordings revealed signs of neuronal dysfunction yet no overt neurodegeneration was observed and visual performance outcomes were unaffected in the App
mouse. Furthermore, we show that hyperspectral imaging can be used to quantify retinal Aβ, underscoring its potential as a biomarker for AD diagnosis and monitoring. These findings suggest that the App
retina mimics the early, preclinical stages of AD, and, together with retinal imaging techniques, offers unique opportunities for drug discovery and fundamental research into preclinical AD. |
| format | Article |
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mouse. We demonstrate that soluble Aβ accumulation is present in the retina of these mice early in life and progresses to Aβ plaque formation by midlife. This rising Aβ burden coincides with local microglia reactivity, astrogliosis, and abnormalities in retinal vein morphology. Electrophysiological recordings revealed signs of neuronal dysfunction yet no overt neurodegeneration was observed and visual performance outcomes were unaffected in the App
mouse. Furthermore, we show that hyperspectral imaging can be used to quantify retinal Aβ, underscoring its potential as a biomarker for AD diagnosis and monitoring. These findings suggest that the App
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mouse. We demonstrate that soluble Aβ accumulation is present in the retina of these mice early in life and progresses to Aβ plaque formation by midlife. This rising Aβ burden coincides with local microglia reactivity, astrogliosis, and abnormalities in retinal vein morphology. Electrophysiological recordings revealed signs of neuronal dysfunction yet no overt neurodegeneration was observed and visual performance outcomes were unaffected in the App
mouse. Furthermore, we show that hyperspectral imaging can be used to quantify retinal Aβ, underscoring its potential as a biomarker for AD diagnosis and monitoring. These findings suggest that the App
retina mimics the early, preclinical stages of AD, and, together with retinal imaging techniques, offers unique opportunities for drug discovery and fundamental research into preclinical AD.</description><subject>Alzheimer Disease - genetics</subject><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer Disease - physiopathology</subject><subject>Amyloid beta-Peptides - metabolism</subject><subject>Amyloid beta-Protein Precursor - genetics</subject><subject>Animals</subject><subject>Disease Progression</subject><subject>Electroretinography</subject><subject>Gliosis - metabolism</subject><subject>Gliosis - pathology</subject><subject>Hyperspectral Imaging</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Microglia - pathology</subject><subject>Microglia - physiology</subject><subject>Peptide Fragments - metabolism</subject><subject>Phenotype</subject><subject>Plaque, Amyloid - metabolism</subject><subject>Plaque, Amyloid - pathology</subject><subject>Plaque, Amyloid - physiopathology</subject><subject>Retina - metabolism</subject><subject>Retina - pathology</subject><subject>Retina - physiopathology</subject><subject>Retinal Neurons - physiology</subject><subject>Retinal Vein - pathology</subject><subject>Tomography, Optical Coherence</subject><issn>2051-5960</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFjr0KwkAQhA9BNKivINtZBS6eP0kpYrQQq_TxTDZm5S45brXQpzeC1k4zMMw3TE8Ec7mMwmWykkMxYb7JTkkUqTgeiKFSC7lOpArEOasRNs7B6RjuwxRs-2AEj3dqNBCDBqY7QtV6cB4LQw0V2sDGvGoki37GUBKj7qCS9LVp-QM1ZTfRpb6ox6JfacM4-fpITNNdtj2E7nGxWObOk9X-mf8uqb-FN6muQWw</recordid><startdate>20210106</startdate><enddate>20210106</enddate><creator>Vandenabeele, Marjan</creator><creator>Veys, Lien</creator><creator>Lemmens, Sophie</creator><creator>Hadoux, Xavier</creator><creator>Gelders, Géraldine</creator><creator>Masin, Luca</creator><creator>Serneels, Lutgarde</creator><creator>Theunis, Jan</creator><creator>Saito, Takashi</creator><creator>Saido, Takaomi C</creator><creator>Jayapala, Murali</creator><creator>De Boever, Patrick</creator><creator>De Strooper, Bart</creator><creator>Stalmans, Ingeborg</creator><creator>van Wijngaarden, Peter</creator><creator>Moons, Lieve</creator><creator>De Groef, Lies</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><orcidid>https://orcid.org/0000-0002-3329-3474</orcidid></search><sort><creationdate>20210106</creationdate><title>The App NL-G-F mouse retina is a site for preclinical Alzheimer's disease diagnosis and research</title><author>Vandenabeele, Marjan ; Veys, Lien ; Lemmens, Sophie ; Hadoux, Xavier ; Gelders, Géraldine ; Masin, Luca ; Serneels, Lutgarde ; Theunis, Jan ; Saito, Takashi ; Saido, Takaomi C ; Jayapala, Murali ; De Boever, Patrick ; De Strooper, Bart ; Stalmans, Ingeborg ; van Wijngaarden, Peter ; Moons, Lieve ; De Groef, Lies</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_334079033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Alzheimer Disease - genetics</topic><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer Disease - physiopathology</topic><topic>Amyloid beta-Peptides - metabolism</topic><topic>Amyloid beta-Protein Precursor - genetics</topic><topic>Animals</topic><topic>Disease Progression</topic><topic>Electroretinography</topic><topic>Gliosis - metabolism</topic><topic>Gliosis - pathology</topic><topic>Hyperspectral Imaging</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>Microglia - pathology</topic><topic>Microglia - physiology</topic><topic>Peptide Fragments - metabolism</topic><topic>Phenotype</topic><topic>Plaque, Amyloid - metabolism</topic><topic>Plaque, Amyloid - pathology</topic><topic>Plaque, Amyloid - physiopathology</topic><topic>Retina - metabolism</topic><topic>Retina - pathology</topic><topic>Retina - physiopathology</topic><topic>Retinal Neurons - physiology</topic><topic>Retinal Vein - pathology</topic><topic>Tomography, Optical Coherence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vandenabeele, Marjan</creatorcontrib><creatorcontrib>Veys, Lien</creatorcontrib><creatorcontrib>Lemmens, Sophie</creatorcontrib><creatorcontrib>Hadoux, Xavier</creatorcontrib><creatorcontrib>Gelders, Géraldine</creatorcontrib><creatorcontrib>Masin, Luca</creatorcontrib><creatorcontrib>Serneels, Lutgarde</creatorcontrib><creatorcontrib>Theunis, Jan</creatorcontrib><creatorcontrib>Saito, Takashi</creatorcontrib><creatorcontrib>Saido, Takaomi C</creatorcontrib><creatorcontrib>Jayapala, Murali</creatorcontrib><creatorcontrib>De Boever, Patrick</creatorcontrib><creatorcontrib>De Strooper, Bart</creatorcontrib><creatorcontrib>Stalmans, Ingeborg</creatorcontrib><creatorcontrib>van Wijngaarden, Peter</creatorcontrib><creatorcontrib>Moons, Lieve</creatorcontrib><creatorcontrib>De Groef, Lies</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Acta neuropathologica communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vandenabeele, Marjan</au><au>Veys, Lien</au><au>Lemmens, Sophie</au><au>Hadoux, Xavier</au><au>Gelders, Géraldine</au><au>Masin, Luca</au><au>Serneels, Lutgarde</au><au>Theunis, Jan</au><au>Saito, Takashi</au><au>Saido, Takaomi C</au><au>Jayapala, Murali</au><au>De Boever, Patrick</au><au>De Strooper, Bart</au><au>Stalmans, Ingeborg</au><au>van Wijngaarden, Peter</au><au>Moons, Lieve</au><au>De Groef, Lies</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The App NL-G-F mouse retina is a site for preclinical Alzheimer's disease diagnosis and research</atitle><jtitle>Acta neuropathologica communications</jtitle><addtitle>Acta Neuropathol Commun</addtitle><date>2021-01-06</date><risdate>2021</risdate><volume>9</volume><issue>1</issue><spage>6</spage><pages>6-</pages><eissn>2051-5960</eissn><abstract>In this study, we report the results of a comprehensive phenotyping of the retina of the App
mouse. We demonstrate that soluble Aβ accumulation is present in the retina of these mice early in life and progresses to Aβ plaque formation by midlife. This rising Aβ burden coincides with local microglia reactivity, astrogliosis, and abnormalities in retinal vein morphology. Electrophysiological recordings revealed signs of neuronal dysfunction yet no overt neurodegeneration was observed and visual performance outcomes were unaffected in the App
mouse. Furthermore, we show that hyperspectral imaging can be used to quantify retinal Aβ, underscoring its potential as a biomarker for AD diagnosis and monitoring. These findings suggest that the App
retina mimics the early, preclinical stages of AD, and, together with retinal imaging techniques, offers unique opportunities for drug discovery and fundamental research into preclinical AD.</abstract><cop>England</cop><pmid>33407903</pmid><orcidid>https://orcid.org/0000-0002-3329-3474</orcidid></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerNature Journals; PubMed Central Open Access; PubMed Central; Springer Nature OA/Free Journals |
| subjects | Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer Disease - physiopathology Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - genetics Animals Disease Progression Electroretinography Gliosis - metabolism Gliosis - pathology Hyperspectral Imaging Mice Mice, Transgenic Microglia - pathology Microglia - physiology Peptide Fragments - metabolism Phenotype Plaque, Amyloid - metabolism Plaque, Amyloid - pathology Plaque, Amyloid - physiopathology Retina - metabolism Retina - pathology Retina - physiopathology Retinal Neurons - physiology Retinal Vein - pathology Tomography, Optical Coherence |
| title | The App NL-G-F mouse retina is a site for preclinical Alzheimer's disease diagnosis and research |
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