Nuclear SR-protein mediated mRNA quality control is continued in cytoplasmic nonsense-mediated decay

One important task of eukaryotic cells is to translate only mRNAs that were correctly processed to prevent the production of truncated proteins, found in neurodegenerative diseases and cancer. Nuclear quality control of splicing requires the SR-like proteins Gbp2 and Hrb1 in S. cerevisiae, where the...

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Veröffentlicht in:	RNA biology 2021-10, Vol.18 (10), p.1390-1407
Hauptverfasser:	Grosse, Sebastian, Lu, Yen-Yun, Coban, Ivo, Neumann, Bettina, Krebber, Heike
Format:	Artikel
Sprache:	eng
Schlagworte:	Codon, Nonsense Cytoplasm - genetics decay Gene Expression Regulation, Fungal mRNA Nonsense Mediated mRNA Decay Nucleocytoplasmic Transport Proteins - metabolism Poly(A)-Binding Proteins - metabolism Research Paper RNA Helicases - metabolism RNA, Fungal - genetics RNA, Messenger - metabolism RNA-Binding Proteins - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - metabolism SR-like proteins surveillance translation Upf1
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