Assessment of atherosclerosis in multiple myeloma and smoldering myeloma patients using 18 F- sodium fluoride PET/CT

To compare the NaF uptake in the thoracic aorta and whole heart, as an early indicator of atherosclerosis, in multiple myeloma (MM) and smoldering multiple myeloma (SMM) patients with a healthy control (HC) group. Forty-four untreated myeloma patients (35 MM and nine SMM) and twenty-six age and gend...

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Veröffentlicht in:Journal of nuclear cardiology 2021-12, Vol.28 (6), p.3044
Hauptverfasser: Arani, Leila S, Zirakchian Zadeh, Mahdi, Saboury, Babak, Revheim, Mona-Elisabeth, Øestergaard, Brian, Borja, Austin J, Samadi Samarin, Davoud, Mehdizadeh Seraj, Siavash, Kalbush, Eman, Ayubcha, Cyrus, Morris, Michael A, Werner, Tom J, Abildgaard, Niels, Høilund-Carlsen, Poul F, Alavi, Abass
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container_issue 6
container_start_page 3044
container_title Journal of nuclear cardiology
container_volume 28
creator Arani, Leila S
Zirakchian Zadeh, Mahdi
Saboury, Babak
Revheim, Mona-Elisabeth
Øestergaard, Brian
Borja, Austin J
Samadi Samarin, Davoud
Mehdizadeh Seraj, Siavash
Kalbush, Eman
Ayubcha, Cyrus
Morris, Michael A
Werner, Tom J
Abildgaard, Niels
Høilund-Carlsen, Poul F
Alavi, Abass
description To compare the NaF uptake in the thoracic aorta and whole heart, as an early indicator of atherosclerosis, in multiple myeloma (MM) and smoldering multiple myeloma (SMM) patients with a healthy control (HC) group. Forty-four untreated myeloma patients (35 MM and nine SMM) and twenty-six age and gender-matched HC subjects were collected. Each individual's NaF uptake in three parts of the aorta (AA: ascending aorta, AR: aortic arch, DA: descending aorta) and the whole heart was segmented. Average global standardized uptake value means were derived by sum of the product of each slice area divided by the sum of those slice areas. Results were reported as target to background ratio (TBR). There was a significant difference between the NaF uptake in the thoracic aorta of myeloma and HC groups [AA (myeloma = 1.82 ± 0.21, HC = 1.24 ± 0.02), AR (myeloma = 1.71 ± 0.19, HC = 1.28 ± 0.03) and DA (myeloma = 1.96 ± 0.28, HC = 1.38 ± 0.03); P-values < 0.001]. The difference in the whole heart NaF uptake between two groups was also significant (P < 0.001). We observed a higher uptake of NaF in the thoracic aorta and whole heart of myeloma patients in comparison to the matched control group.
doi_str_mv 10.1007/s12350-020-02446-0
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subjects Atherosclerosis - complications
Atherosclerosis - diagnostic imaging
Fluorine Radioisotopes
Humans
Multiple Myeloma - complications
Positron Emission Tomography Computed Tomography - methods
Retrospective Studies
Smoldering Multiple Myeloma - complications
Sodium Fluoride
title Assessment of atherosclerosis in multiple myeloma and smoldering myeloma patients using 18 F- sodium fluoride PET/CT
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