Assessment of atherosclerosis in multiple myeloma and smoldering myeloma patients using 18 F- sodium fluoride PET/CT
To compare the NaF uptake in the thoracic aorta and whole heart, as an early indicator of atherosclerosis, in multiple myeloma (MM) and smoldering multiple myeloma (SMM) patients with a healthy control (HC) group. Forty-four untreated myeloma patients (35 MM and nine SMM) and twenty-six age and gend...
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Veröffentlicht in: | Journal of nuclear cardiology 2021-12, Vol.28 (6), p.3044 |
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creator | Arani, Leila S Zirakchian Zadeh, Mahdi Saboury, Babak Revheim, Mona-Elisabeth Øestergaard, Brian Borja, Austin J Samadi Samarin, Davoud Mehdizadeh Seraj, Siavash Kalbush, Eman Ayubcha, Cyrus Morris, Michael A Werner, Tom J Abildgaard, Niels Høilund-Carlsen, Poul F Alavi, Abass |
description | To compare the NaF uptake in the thoracic aorta and whole heart, as an early indicator of atherosclerosis, in multiple myeloma (MM) and smoldering multiple myeloma (SMM) patients with a healthy control (HC) group.
Forty-four untreated myeloma patients (35 MM and nine SMM) and twenty-six age and gender-matched HC subjects were collected. Each individual's NaF uptake in three parts of the aorta (AA: ascending aorta, AR: aortic arch, DA: descending aorta) and the whole heart was segmented. Average global standardized uptake value means were derived by sum of the product of each slice area divided by the sum of those slice areas. Results were reported as target to background ratio (TBR).
There was a significant difference between the NaF uptake in the thoracic aorta of myeloma and HC groups [AA (myeloma = 1.82 ± 0.21, HC = 1.24 ± 0.02), AR (myeloma = 1.71 ± 0.19, HC = 1.28 ± 0.03) and DA (myeloma = 1.96 ± 0.28, HC = 1.38 ± 0.03); P-values < 0.001]. The difference in the whole heart NaF uptake between two groups was also significant (P < 0.001).
We observed a higher uptake of NaF in the thoracic aorta and whole heart of myeloma patients in comparison to the matched control group. |
doi_str_mv | 10.1007/s12350-020-02446-0 |
format | Article |
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Forty-four untreated myeloma patients (35 MM and nine SMM) and twenty-six age and gender-matched HC subjects were collected. Each individual's NaF uptake in three parts of the aorta (AA: ascending aorta, AR: aortic arch, DA: descending aorta) and the whole heart was segmented. Average global standardized uptake value means were derived by sum of the product of each slice area divided by the sum of those slice areas. Results were reported as target to background ratio (TBR).
There was a significant difference between the NaF uptake in the thoracic aorta of myeloma and HC groups [AA (myeloma = 1.82 ± 0.21, HC = 1.24 ± 0.02), AR (myeloma = 1.71 ± 0.19, HC = 1.28 ± 0.03) and DA (myeloma = 1.96 ± 0.28, HC = 1.38 ± 0.03); P-values < 0.001]. The difference in the whole heart NaF uptake between two groups was also significant (P < 0.001).
We observed a higher uptake of NaF in the thoracic aorta and whole heart of myeloma patients in comparison to the matched control group.</description><identifier>EISSN: 1532-6551</identifier><identifier>DOI: 10.1007/s12350-020-02446-0</identifier><identifier>PMID: 33389640</identifier><language>eng</language><publisher>United States</publisher><subject>Atherosclerosis - complications ; Atherosclerosis - diagnostic imaging ; Fluorine Radioisotopes ; Humans ; Multiple Myeloma - complications ; Positron Emission Tomography Computed Tomography - methods ; Retrospective Studies ; Smoldering Multiple Myeloma - complications ; Sodium Fluoride</subject><ispartof>Journal of nuclear cardiology, 2021-12, Vol.28 (6), p.3044</ispartof><rights>2021. American Society of Nuclear Cardiology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33389640$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arani, Leila S</creatorcontrib><creatorcontrib>Zirakchian Zadeh, Mahdi</creatorcontrib><creatorcontrib>Saboury, Babak</creatorcontrib><creatorcontrib>Revheim, Mona-Elisabeth</creatorcontrib><creatorcontrib>Øestergaard, Brian</creatorcontrib><creatorcontrib>Borja, Austin J</creatorcontrib><creatorcontrib>Samadi Samarin, Davoud</creatorcontrib><creatorcontrib>Mehdizadeh Seraj, Siavash</creatorcontrib><creatorcontrib>Kalbush, Eman</creatorcontrib><creatorcontrib>Ayubcha, Cyrus</creatorcontrib><creatorcontrib>Morris, Michael A</creatorcontrib><creatorcontrib>Werner, Tom J</creatorcontrib><creatorcontrib>Abildgaard, Niels</creatorcontrib><creatorcontrib>Høilund-Carlsen, Poul F</creatorcontrib><creatorcontrib>Alavi, Abass</creatorcontrib><title>Assessment of atherosclerosis in multiple myeloma and smoldering myeloma patients using 18 F- sodium fluoride PET/CT</title><title>Journal of nuclear cardiology</title><addtitle>J Nucl Cardiol</addtitle><description>To compare the NaF uptake in the thoracic aorta and whole heart, as an early indicator of atherosclerosis, in multiple myeloma (MM) and smoldering multiple myeloma (SMM) patients with a healthy control (HC) group.
Forty-four untreated myeloma patients (35 MM and nine SMM) and twenty-six age and gender-matched HC subjects were collected. Each individual's NaF uptake in three parts of the aorta (AA: ascending aorta, AR: aortic arch, DA: descending aorta) and the whole heart was segmented. Average global standardized uptake value means were derived by sum of the product of each slice area divided by the sum of those slice areas. Results were reported as target to background ratio (TBR).
There was a significant difference between the NaF uptake in the thoracic aorta of myeloma and HC groups [AA (myeloma = 1.82 ± 0.21, HC = 1.24 ± 0.02), AR (myeloma = 1.71 ± 0.19, HC = 1.28 ± 0.03) and DA (myeloma = 1.96 ± 0.28, HC = 1.38 ± 0.03); P-values < 0.001]. The difference in the whole heart NaF uptake between two groups was also significant (P < 0.001).
We observed a higher uptake of NaF in the thoracic aorta and whole heart of myeloma patients in comparison to the matched control group.</description><subject>Atherosclerosis - complications</subject><subject>Atherosclerosis - diagnostic imaging</subject><subject>Fluorine Radioisotopes</subject><subject>Humans</subject><subject>Multiple Myeloma - complications</subject><subject>Positron Emission Tomography Computed Tomography - methods</subject><subject>Retrospective Studies</subject><subject>Smoldering Multiple Myeloma - complications</subject><subject>Sodium Fluoride</subject><issn>1532-6551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFjs1qwzAQhEWhJOnPC_RQ9gXUrCzbjY8lJPSYg-9BrdapimQZrXTI27eGpNceZgY-hmGEeFL4ohBf16wq3aDEalZdtxJvxEo1upJt06iluGP-RsROd91CLLXWm66tcSXyGzMxBxozxAFM_qIU-dPP7hjcCKH47CZPEM7kYzBgRgscoreU3Hj6w5PJ7neFofCM1Qb2EjhaVwIMvsTkLMFh16-3_YO4HYxnerzkvXje7_rtu5zKRyB7nJILJp2P15v638IPnjRO3A</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Arani, Leila S</creator><creator>Zirakchian Zadeh, Mahdi</creator><creator>Saboury, Babak</creator><creator>Revheim, Mona-Elisabeth</creator><creator>Øestergaard, Brian</creator><creator>Borja, Austin J</creator><creator>Samadi Samarin, Davoud</creator><creator>Mehdizadeh Seraj, Siavash</creator><creator>Kalbush, Eman</creator><creator>Ayubcha, Cyrus</creator><creator>Morris, Michael A</creator><creator>Werner, Tom J</creator><creator>Abildgaard, Niels</creator><creator>Høilund-Carlsen, Poul F</creator><creator>Alavi, Abass</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>202112</creationdate><title>Assessment of atherosclerosis in multiple myeloma and smoldering myeloma patients using 18 F- sodium fluoride PET/CT</title><author>Arani, Leila S ; Zirakchian Zadeh, Mahdi ; Saboury, Babak ; Revheim, Mona-Elisabeth ; Øestergaard, Brian ; Borja, Austin J ; Samadi Samarin, Davoud ; Mehdizadeh Seraj, Siavash ; Kalbush, Eman ; Ayubcha, Cyrus ; Morris, Michael A ; Werner, Tom J ; Abildgaard, Niels ; Høilund-Carlsen, Poul F ; Alavi, Abass</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_333896403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Atherosclerosis - complications</topic><topic>Atherosclerosis - diagnostic imaging</topic><topic>Fluorine Radioisotopes</topic><topic>Humans</topic><topic>Multiple Myeloma - complications</topic><topic>Positron Emission Tomography Computed Tomography - methods</topic><topic>Retrospective Studies</topic><topic>Smoldering Multiple Myeloma - complications</topic><topic>Sodium Fluoride</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arani, Leila S</creatorcontrib><creatorcontrib>Zirakchian Zadeh, Mahdi</creatorcontrib><creatorcontrib>Saboury, Babak</creatorcontrib><creatorcontrib>Revheim, Mona-Elisabeth</creatorcontrib><creatorcontrib>Øestergaard, Brian</creatorcontrib><creatorcontrib>Borja, Austin J</creatorcontrib><creatorcontrib>Samadi Samarin, Davoud</creatorcontrib><creatorcontrib>Mehdizadeh Seraj, Siavash</creatorcontrib><creatorcontrib>Kalbush, Eman</creatorcontrib><creatorcontrib>Ayubcha, Cyrus</creatorcontrib><creatorcontrib>Morris, Michael A</creatorcontrib><creatorcontrib>Werner, Tom J</creatorcontrib><creatorcontrib>Abildgaard, Niels</creatorcontrib><creatorcontrib>Høilund-Carlsen, Poul F</creatorcontrib><creatorcontrib>Alavi, Abass</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Journal of nuclear cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arani, Leila S</au><au>Zirakchian Zadeh, Mahdi</au><au>Saboury, Babak</au><au>Revheim, Mona-Elisabeth</au><au>Øestergaard, Brian</au><au>Borja, Austin J</au><au>Samadi Samarin, Davoud</au><au>Mehdizadeh Seraj, Siavash</au><au>Kalbush, Eman</au><au>Ayubcha, Cyrus</au><au>Morris, Michael A</au><au>Werner, Tom J</au><au>Abildgaard, Niels</au><au>Høilund-Carlsen, Poul F</au><au>Alavi, Abass</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of atherosclerosis in multiple myeloma and smoldering myeloma patients using 18 F- sodium fluoride PET/CT</atitle><jtitle>Journal of nuclear cardiology</jtitle><addtitle>J Nucl Cardiol</addtitle><date>2021-12</date><risdate>2021</risdate><volume>28</volume><issue>6</issue><spage>3044</spage><pages>3044-</pages><eissn>1532-6551</eissn><abstract>To compare the NaF uptake in the thoracic aorta and whole heart, as an early indicator of atherosclerosis, in multiple myeloma (MM) and smoldering multiple myeloma (SMM) patients with a healthy control (HC) group.
Forty-four untreated myeloma patients (35 MM and nine SMM) and twenty-six age and gender-matched HC subjects were collected. Each individual's NaF uptake in three parts of the aorta (AA: ascending aorta, AR: aortic arch, DA: descending aorta) and the whole heart was segmented. Average global standardized uptake value means were derived by sum of the product of each slice area divided by the sum of those slice areas. Results were reported as target to background ratio (TBR).
There was a significant difference between the NaF uptake in the thoracic aorta of myeloma and HC groups [AA (myeloma = 1.82 ± 0.21, HC = 1.24 ± 0.02), AR (myeloma = 1.71 ± 0.19, HC = 1.28 ± 0.03) and DA (myeloma = 1.96 ± 0.28, HC = 1.38 ± 0.03); P-values < 0.001]. The difference in the whole heart NaF uptake between two groups was also significant (P < 0.001).
We observed a higher uptake of NaF in the thoracic aorta and whole heart of myeloma patients in comparison to the matched control group.</abstract><cop>United States</cop><pmid>33389640</pmid><doi>10.1007/s12350-020-02446-0</doi></addata></record> |
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subjects | Atherosclerosis - complications Atherosclerosis - diagnostic imaging Fluorine Radioisotopes Humans Multiple Myeloma - complications Positron Emission Tomography Computed Tomography - methods Retrospective Studies Smoldering Multiple Myeloma - complications Sodium Fluoride |
title | Assessment of atherosclerosis in multiple myeloma and smoldering myeloma patients using 18 F- sodium fluoride PET/CT |
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