Aster tataricus alleviates constipation by antagonizing the binding of acetylcholine to muscarinic receptor and inhibiting Ca 2+ influx

The dried root and rhizome of Aster tataricus (RA), is a traditional Chinese medicine has been used for more than 2000 years with the function of antitussive, expectorant and antiasthmatic. Ancient books and modern pharmacological researches demonstrated that RA may have the function of moistening i...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2021-01, Vol.133, p.111005
Hauptverfasser:	Wu, Hao, Chen, Yijun, Huang, Beibei, Yu, Yingting, Zhao, Shujun, Liu, Jie, Jia, Zhixin, Xiao, Hongbin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Aster Plant - chemistry Calcium Signaling - drug effects Constipation - chemically induced Constipation - drug therapy Constipation - metabolism Constipation - physiopathology Defecation - drug effects Disease Models, Animal Duodenum - drug effects Duodenum - metabolism Duodenum - physiopathology Gastrointestinal Transit - drug effects Laxatives - isolation & purification Laxatives - pharmacology Loperamide Mice Muscarinic Antagonists - isolation & purification Muscarinic Antagonists - pharmacology Plant Extracts - isolation & purification Plant Extracts - pharmacology Rats Rats, Sprague-Dawley
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