Modulatory Effects of Autophagy on APP Processing as a Potential Treatment Target for Alzheimer's Disease

Alzheimer's disease (AD) is characterized by the formation of intracellular aggregate composed of heavily phosphorylated tau protein and extracellular deposit of amyloid-beta (A beta) plaques derived from proteolysis cleavage of amyloid precursor protein (APP). Autophagy refers to the lysosomal...

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Veröffentlicht in:	Biomedicines 2020-12, Vol.9 (1), p.5, Article 5
Hauptverfasser:	Rahman, Md. Ataur, Rahman, Md Saidur, Rahman, MD. Hasanur, Rasheduzzaman, Mohammad, Mamun-Or-Rashid, A. N. M., Uddin, Md Jamal, Rahman, Md Rezanur, Hwang, Hongik, Pang, Myung-Geol, Rhim, Hyewhon
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Alzheimer’s disease (AD) Amyloid precursor protein amyloid precursor protein (APP) Autophagy Axons Biochemistry & Molecular Biology Disease Homeostasis Kinases Life Sciences & Biomedicine Medicine, Research & Experimental mTOR Mutation Neurodegenerative diseases Pathogenesis Peptides Phagocytosis Pharmacology & Pharmacy Phosphorylation Physiology Proteins Proteolysis Research & Experimental Medicine Review Science & Technology Senile plaques Tau protein TOR protein Vacuoles β-amyloid (Aβ)
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