Longitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19
Understanding the processes of immune regulation in patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for improving treatment. Here, we performed longitudinal whole-transcriptome RNA sequencing on peripheral blood mononuclear cell (PBMC) samples from...
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| Veröffentlicht in: | Signal transduction and targeted therapy 2020-12, Vol.5 (1), p.294-294, Article 294 |
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| creator | Zheng, Hong-Yi Xu, Min Yang, Cui-Xian Tian, Ren-Rong Zhang, Mi Li, Jian-Jian Wang, Xi-Cheng Ding, Zhao-Li Li, Gui-Mei Li, Xiao-Lu He, Yu-Qi Dong, Xing-Qi Yao, Yong-Gang Zheng, Yong-Tang |
| description | Understanding the processes of immune regulation in patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for improving treatment. Here, we performed longitudinal whole-transcriptome RNA sequencing on peripheral blood mononuclear cell (PBMC) samples from 18 patients with coronavirus disease 2019 (COVID-19) during their treatment, convalescence, and rehabilitation. After analyzing the regulatory networks of differentially expressed messenger RNAs (mRNAs), microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) between the different clinical stages, we found that humoral immunity and type I interferon response were significantly downregulated, while robust T-cell activation and differentiation at the whole transcriptome level constituted the main events that occurred during recovery from COVID-19. The formation of this T cell immune response might be driven by the activation of activating protein-1 (AP-1) related signaling pathway and was weakly affected by other clinical features. These findings uncovered the dynamic pattern of immune responses and indicated the key role of T cell immunity in the creation of immune protection against this disease. |
| doi_str_mv | 10.1038/s41392-020-00457-4 |
| format | Article |
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These findings uncovered the dynamic pattern of immune responses and indicated the key role of T cell immunity in the creation of immune protection against this disease.</description><identifier>ISSN: 2059-3635</identifier><identifier>ISSN: 2095-9907</identifier><identifier>EISSN: 2059-3635</identifier><identifier>DOI: 10.1038/s41392-020-00457-4</identifier><identifier>PMID: 33361761</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/114/2785 ; 631/250/255 ; Cancer Research ; Cell Biology ; Coronaviruses ; COVID-19 ; COVID-19 - epidemiology ; COVID-19 - genetics ; COVID-19 - pathology ; Female ; Humans ; Immunity, Humoral - genetics ; Immunity, Humoral - immunology ; Internal Medicine ; Leukocytes, Mononuclear - metabolism ; Lymphocytes ; Male ; Medicine ; Medicine & Public Health ; MicroRNAs ; Oncology ; Pathology ; RNA, Long Noncoding - genetics ; RNA-Seq ; SARS-CoV-2 - genetics ; SARS-CoV-2 - pathogenicity ; Severe acute respiratory syndrome coronavirus 2 ; T-Lymphocytes - immunology ; T-Lymphocytes - metabolism ; T-Lymphocytes - pathology ; Transcription Factor AP-1 - genetics ; Transcriptome - genetics</subject><ispartof>Signal transduction and targeted therapy, 2020-12, Vol.5 (1), p.294-294, Article 294</ispartof><rights>The Author(s) 2021</rights><rights>The Author(s) 2021. 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| subjects | 631/114/2785 631/250/255 Cancer Research Cell Biology Coronaviruses COVID-19 COVID-19 - epidemiology COVID-19 - genetics COVID-19 - pathology Female Humans Immunity, Humoral - genetics Immunity, Humoral - immunology Internal Medicine Leukocytes, Mononuclear - metabolism Lymphocytes Male Medicine Medicine & Public Health MicroRNAs Oncology Pathology RNA, Long Noncoding - genetics RNA-Seq SARS-CoV-2 - genetics SARS-CoV-2 - pathogenicity Severe acute respiratory syndrome coronavirus 2 T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes - pathology Transcription Factor AP-1 - genetics Transcriptome - genetics |
| title | Longitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19 |
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