Progastrin production transitions from Bmi1 + /Prox1 + to Lgr5 high cells during early intestinal tumorigenesis

Progastrin is an unprocessed soluble peptide precursor with a well-described tumor-promoting role in colorectal cancer. It is expressed at small levels in the healthy intestinal mucosa, and its expression is enhanced at early stages of intestinal tumor development, with high levels of this peptide i...

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Veröffentlicht in:	Translational oncology 2021-02, Vol.14 (2), p.101001
Hauptverfasser:	Giraud, J, Foroutan, M, Boubaker-Vitre, J, Grillet, F, Homayed, Z, Jadhav, U, Crespy, P, Breuker, C, Bourgaux, J-F, Hazerbroucq, J, Pignodel, C, Brulin, B, Shivdasani, R A, Jay, P, Hollande, F, Pannequin, J
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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