Coronary 18 F-sodium fluoride PET detects high-risk plaque features on optical coherence tomography and CT-angiography in patients with acute coronary syndrome
F-Sodium Fluoride Positron Emission Tomography ( F-NaF PET) non-invasively detects micro-calcification activity, the earliest stage of atherosclerotic arterial calcification. We studied the association between coronary F-NaF uptake and high-risk plaque features on intra-coronary optical coherence to...
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| Veröffentlicht in: | Atherosclerosis 2021-02, Vol.319, p.142 |
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| creator | Majeed, Kamran Bellinge, Jamie W Butcher, Steele C Alcock, Richard Spiro, Jon Playford, David Hillis, Graham S Newby, David E Mori, Trevor A Francis, Roslyn Schultz, Carl J |
| description | F-Sodium Fluoride Positron Emission Tomography (
F-NaF PET) non-invasively detects micro-calcification activity, the earliest stage of atherosclerotic arterial calcification. We studied the association between coronary
F-NaF uptake and high-risk plaque features on intra-coronary optical coherence tomography (OCT) and CT-angiography (CTCA) and the potential application to patient-level risk stratification.
Sixty-two prospectively recruited patients with acute coronary syndrome (ACS) underwent multi-vessel OCT,
F-NaF PET and CTCA. The maximum tissue to background ratio (TBRmax = standardised uptake value (SUV)max/SUVbloodpool) was measured in each coronary segment on
F-NaF PET scans. High-risk plaque features on OCT and CTCA were compared in matched coronary segments. The number of patients testing positive (>2SD above the normal range) for micro-calcification activity was determined.
In 62 patients (age, mean ± standard deviation (SD) = 61 ± 9 years, 85% male) the coronary segments with elevated
F-NaF uptake had higher lipid arc (LA) (median [25th-75th centile]: 74° [35°-117°] versus 48° [15°-83°], p=0.021), higher prevalence of macrophages [n(%): 37 (62%) versus 89 (39%), p=0.008] and lower plaque free wall (PFW) (50° [7°-110°] versus 94° [34°-180°], p=0.027) on OCT, and a higher total plaque burden (p=0.011) and higher dense calcified plaque burden (p= 0.001) on CTCA, when compared with
F-NaF negative segments. Patients grouped by increasing number of coronary lesions positive for microcalcification activity (0,1, ≥2) showed decreasing plaque free wall, increasing calcification and increasing macrophages on OCT (respectively p=0.008, p |
| format | Article |
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F-NaF PET) non-invasively detects micro-calcification activity, the earliest stage of atherosclerotic arterial calcification. We studied the association between coronary
F-NaF uptake and high-risk plaque features on intra-coronary optical coherence tomography (OCT) and CT-angiography (CTCA) and the potential application to patient-level risk stratification.
Sixty-two prospectively recruited patients with acute coronary syndrome (ACS) underwent multi-vessel OCT,
F-NaF PET and CTCA. The maximum tissue to background ratio (TBRmax = standardised uptake value (SUV)max/SUVbloodpool) was measured in each coronary segment on
F-NaF PET scans. High-risk plaque features on OCT and CTCA were compared in matched coronary segments. The number of patients testing positive (>2SD above the normal range) for micro-calcification activity was determined.
In 62 patients (age, mean ± standard deviation (SD) = 61 ± 9 years, 85% male) the coronary segments with elevated
F-NaF uptake had higher lipid arc (LA) (median [25th-75th centile]: 74° [35°-117°] versus 48° [15°-83°], p=0.021), higher prevalence of macrophages [n(%): 37 (62%) versus 89 (39%), p=0.008] and lower plaque free wall (PFW) (50° [7°-110°] versus 94° [34°-180°], p=0.027) on OCT, and a higher total plaque burden (p=0.011) and higher dense calcified plaque burden (p= 0.001) on CTCA, when compared with
F-NaF negative segments. Patients grouped by increasing number of coronary lesions positive for microcalcification activity (0,1, ≥2) showed decreasing plaque free wall, increasing calcification and increasing macrophages on OCT (respectively p=0.008, p < 0.001 and p=0.028).
F-NaF uptake is associated with high-risk plaque features on OCT and CTCA in a per-segment and per-patient analysis in subjects hospitalized for ACS.</description><identifier>EISSN: 1879-1484</identifier><identifier>PMID: 33358367</identifier><language>eng</language><publisher>Ireland</publisher><subject>Acute Coronary Syndrome - diagnostic imaging ; Aged ; Angiography ; Coronary Artery Disease - diagnostic imaging ; Female ; Fluorine Radioisotopes ; Humans ; Male ; Middle Aged ; Plaque, Atherosclerotic ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography ; Radiopharmaceuticals ; Sodium Fluoride ; Tomography, Optical Coherence</subject><ispartof>Atherosclerosis, 2021-02, Vol.319, p.142</ispartof><rights>Crown Copyright © 2020. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33358367$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Majeed, Kamran</creatorcontrib><creatorcontrib>Bellinge, Jamie W</creatorcontrib><creatorcontrib>Butcher, Steele C</creatorcontrib><creatorcontrib>Alcock, Richard</creatorcontrib><creatorcontrib>Spiro, Jon</creatorcontrib><creatorcontrib>Playford, David</creatorcontrib><creatorcontrib>Hillis, Graham S</creatorcontrib><creatorcontrib>Newby, David E</creatorcontrib><creatorcontrib>Mori, Trevor A</creatorcontrib><creatorcontrib>Francis, Roslyn</creatorcontrib><creatorcontrib>Schultz, Carl J</creatorcontrib><title>Coronary 18 F-sodium fluoride PET detects high-risk plaque features on optical coherence tomography and CT-angiography in patients with acute coronary syndrome</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>F-Sodium Fluoride Positron Emission Tomography (
F-NaF PET) non-invasively detects micro-calcification activity, the earliest stage of atherosclerotic arterial calcification. We studied the association between coronary
F-NaF uptake and high-risk plaque features on intra-coronary optical coherence tomography (OCT) and CT-angiography (CTCA) and the potential application to patient-level risk stratification.
Sixty-two prospectively recruited patients with acute coronary syndrome (ACS) underwent multi-vessel OCT,
F-NaF PET and CTCA. The maximum tissue to background ratio (TBRmax = standardised uptake value (SUV)max/SUVbloodpool) was measured in each coronary segment on
F-NaF PET scans. High-risk plaque features on OCT and CTCA were compared in matched coronary segments. The number of patients testing positive (>2SD above the normal range) for micro-calcification activity was determined.
In 62 patients (age, mean ± standard deviation (SD) = 61 ± 9 years, 85% male) the coronary segments with elevated
F-NaF uptake had higher lipid arc (LA) (median [25th-75th centile]: 74° [35°-117°] versus 48° [15°-83°], p=0.021), higher prevalence of macrophages [n(%): 37 (62%) versus 89 (39%), p=0.008] and lower plaque free wall (PFW) (50° [7°-110°] versus 94° [34°-180°], p=0.027) on OCT, and a higher total plaque burden (p=0.011) and higher dense calcified plaque burden (p= 0.001) on CTCA, when compared with
F-NaF negative segments. Patients grouped by increasing number of coronary lesions positive for microcalcification activity (0,1, ≥2) showed decreasing plaque free wall, increasing calcification and increasing macrophages on OCT (respectively p=0.008, p < 0.001 and p=0.028).
F-NaF uptake is associated with high-risk plaque features on OCT and CTCA in a per-segment and per-patient analysis in subjects hospitalized for ACS.</description><subject>Acute Coronary Syndrome - diagnostic imaging</subject><subject>Aged</subject><subject>Angiography</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Female</subject><subject>Fluorine Radioisotopes</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Plaque, Atherosclerotic</subject><subject>Positron Emission Tomography Computed Tomography</subject><subject>Positron-Emission Tomography</subject><subject>Radiopharmaceuticals</subject><subject>Sodium Fluoride</subject><subject>Tomography, Optical Coherence</subject><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFj01OwzAUhC0kREvhCuhdwFIiB2LWUSuWLLKvjP0SG2I_4x-hnIarkkW7ZjXS6JvRzA3bt7J_5W0nux27z_mzaZqub-Ud2wkhnqV46ffsd6BEQaUVWgknnsm46mFaKiVnEN6PIxgsqEsG62bLk8tfEBf1XREmVKUmzEABKBan1QKaLCYMGqGQpzmpaFdQwcAwchVmd7VcgKiKw7AV_7hiQelacItf1uQ1mEQeH9jtpJaMjxc9sKfTcRzeeKwfHs05Juc3_nx9JP4F_gDoTFn_</recordid><startdate>202102</startdate><enddate>202102</enddate><creator>Majeed, Kamran</creator><creator>Bellinge, Jamie W</creator><creator>Butcher, Steele C</creator><creator>Alcock, Richard</creator><creator>Spiro, Jon</creator><creator>Playford, David</creator><creator>Hillis, Graham S</creator><creator>Newby, David E</creator><creator>Mori, Trevor A</creator><creator>Francis, Roslyn</creator><creator>Schultz, Carl J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>202102</creationdate><title>Coronary 18 F-sodium fluoride PET detects high-risk plaque features on optical coherence tomography and CT-angiography in patients with acute coronary syndrome</title><author>Majeed, Kamran ; Bellinge, Jamie W ; Butcher, Steele C ; Alcock, Richard ; Spiro, Jon ; Playford, David ; Hillis, Graham S ; Newby, David E ; Mori, Trevor A ; Francis, Roslyn ; Schultz, Carl J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_333583673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acute Coronary Syndrome - diagnostic imaging</topic><topic>Aged</topic><topic>Angiography</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Female</topic><topic>Fluorine Radioisotopes</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Plaque, Atherosclerotic</topic><topic>Positron Emission Tomography Computed Tomography</topic><topic>Positron-Emission Tomography</topic><topic>Radiopharmaceuticals</topic><topic>Sodium Fluoride</topic><topic>Tomography, Optical Coherence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Majeed, Kamran</creatorcontrib><creatorcontrib>Bellinge, Jamie W</creatorcontrib><creatorcontrib>Butcher, Steele C</creatorcontrib><creatorcontrib>Alcock, Richard</creatorcontrib><creatorcontrib>Spiro, Jon</creatorcontrib><creatorcontrib>Playford, David</creatorcontrib><creatorcontrib>Hillis, Graham S</creatorcontrib><creatorcontrib>Newby, David E</creatorcontrib><creatorcontrib>Mori, Trevor A</creatorcontrib><creatorcontrib>Francis, Roslyn</creatorcontrib><creatorcontrib>Schultz, Carl J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Majeed, Kamran</au><au>Bellinge, Jamie W</au><au>Butcher, Steele C</au><au>Alcock, Richard</au><au>Spiro, Jon</au><au>Playford, David</au><au>Hillis, Graham S</au><au>Newby, David E</au><au>Mori, Trevor A</au><au>Francis, Roslyn</au><au>Schultz, Carl J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Coronary 18 F-sodium fluoride PET detects high-risk plaque features on optical coherence tomography and CT-angiography in patients with acute coronary syndrome</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>2021-02</date><risdate>2021</risdate><volume>319</volume><spage>142</spage><pages>142-</pages><eissn>1879-1484</eissn><abstract>F-Sodium Fluoride Positron Emission Tomography (
F-NaF PET) non-invasively detects micro-calcification activity, the earliest stage of atherosclerotic arterial calcification. We studied the association between coronary
F-NaF uptake and high-risk plaque features on intra-coronary optical coherence tomography (OCT) and CT-angiography (CTCA) and the potential application to patient-level risk stratification.
Sixty-two prospectively recruited patients with acute coronary syndrome (ACS) underwent multi-vessel OCT,
F-NaF PET and CTCA. The maximum tissue to background ratio (TBRmax = standardised uptake value (SUV)max/SUVbloodpool) was measured in each coronary segment on
F-NaF PET scans. High-risk plaque features on OCT and CTCA were compared in matched coronary segments. The number of patients testing positive (>2SD above the normal range) for micro-calcification activity was determined.
In 62 patients (age, mean ± standard deviation (SD) = 61 ± 9 years, 85% male) the coronary segments with elevated
F-NaF uptake had higher lipid arc (LA) (median [25th-75th centile]: 74° [35°-117°] versus 48° [15°-83°], p=0.021), higher prevalence of macrophages [n(%): 37 (62%) versus 89 (39%), p=0.008] and lower plaque free wall (PFW) (50° [7°-110°] versus 94° [34°-180°], p=0.027) on OCT, and a higher total plaque burden (p=0.011) and higher dense calcified plaque burden (p= 0.001) on CTCA, when compared with
F-NaF negative segments. Patients grouped by increasing number of coronary lesions positive for microcalcification activity (0,1, ≥2) showed decreasing plaque free wall, increasing calcification and increasing macrophages on OCT (respectively p=0.008, p < 0.001 and p=0.028).
F-NaF uptake is associated with high-risk plaque features on OCT and CTCA in a per-segment and per-patient analysis in subjects hospitalized for ACS.</abstract><cop>Ireland</cop><pmid>33358367</pmid></addata></record> |
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| ispartof | Atherosclerosis, 2021-02, Vol.319, p.142 |
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| subjects | Acute Coronary Syndrome - diagnostic imaging Aged Angiography Coronary Artery Disease - diagnostic imaging Female Fluorine Radioisotopes Humans Male Middle Aged Plaque, Atherosclerotic Positron Emission Tomography Computed Tomography Positron-Emission Tomography Radiopharmaceuticals Sodium Fluoride Tomography, Optical Coherence |
| title | Coronary 18 F-sodium fluoride PET detects high-risk plaque features on optical coherence tomography and CT-angiography in patients with acute coronary syndrome |
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