Effect of cis-diamminedichloroplatinum(II) combined with whole body hyperthermia on renal injury

The effect of whole body hyperthermia (WBH) on cis-diamminedichloroplatinum (II) (DDP) induced renal toxicity and antitumor effect was studied using a F344 rat model. Renal injury at 5 and 14 days after treatment was evaluated using animal mortality, renal functional assays (blood urea nitrogen, cre...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1988-01, Vol.48 (2), p.440-446
Hauptverfasser:	WONDERGEM, J, BULGER, R. E, STREBEL, F. R, NEWMAN, R. A, TRAVIS, E. L, STEPHENS, L. C, BULL, J. M. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Urea Nitrogen Cisplatin - therapeutic use Cisplatin - toxicity Combined Modality Therapy Creatinine - blood Drug toxicity and drugs side effects treatment Female Fibrosarcoma - therapy Hyperthermia, Induced Kidney - drug effects Kidney - pathology Medical sciences Necrosis Pharmacology. Drug treatments Rats Rats, Inbred F344 Time Factors Toxicity: urogenital system
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