Effect of cis-diamminedichloroplatinum(II) combined with whole body hyperthermia on renal injury
The effect of whole body hyperthermia (WBH) on cis-diamminedichloroplatinum (II) (DDP) induced renal toxicity and antitumor effect was studied using a F344 rat model. Renal injury at 5 and 14 days after treatment was evaluated using animal mortality, renal functional assays (blood urea nitrogen, cre...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 1988-01, Vol.48 (2), p.440-446 |
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| container_title | Cancer research (Chicago, Ill.) |
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| creator | WONDERGEM, J BULGER, R. E STREBEL, F. R NEWMAN, R. A TRAVIS, E. L STEPHENS, L. C BULL, J. M. C |
| description | The effect of whole body hyperthermia (WBH) on cis-diamminedichloroplatinum (II) (DDP) induced renal toxicity and antitumor effect was studied using a F344 rat model. Renal injury at 5 and 14 days after treatment was evaluated using animal mortality, renal functional assays (blood urea nitrogen, creatinine), and histopathological methods. WBH (120 min at 41.5 degrees C) enhanced both antitumor effects and toxic side effects. The latter included increased mortality, increased blood urea nitrogen and creatinine levels, and increased renal damage. After simultaneous treatment with WBH and DDP, thermal enhancement ratios (TER) for renal damage between 2.5 and 3.0 were calculated. The histopathological changes observed in the kidney after DDP alone or combined with WBH were primarily found in the proximal pars recta tubules (S3 segment) in the outer stripe of the outer medulla. There was no qualitative difference in tubular damage between rats treated with DDP alone or those treated with DDP combined with WBH. However, at a fixed DDP dose, damage in the combined treatment modality group was significantly greater than in the DDP-only treated group. |
| format | Article |
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E ; STREBEL, F. R ; NEWMAN, R. A ; TRAVIS, E. L ; STEPHENS, L. C ; BULL, J. M. C</creator><creatorcontrib>WONDERGEM, J ; BULGER, R. E ; STREBEL, F. R ; NEWMAN, R. A ; TRAVIS, E. L ; STEPHENS, L. C ; BULL, J. M. C</creatorcontrib><description>The effect of whole body hyperthermia (WBH) on cis-diamminedichloroplatinum (II) (DDP) induced renal toxicity and antitumor effect was studied using a F344 rat model. Renal injury at 5 and 14 days after treatment was evaluated using animal mortality, renal functional assays (blood urea nitrogen, creatinine), and histopathological methods. WBH (120 min at 41.5 degrees C) enhanced both antitumor effects and toxic side effects. The latter included increased mortality, increased blood urea nitrogen and creatinine levels, and increased renal damage. After simultaneous treatment with WBH and DDP, thermal enhancement ratios (TER) for renal damage between 2.5 and 3.0 were calculated. The histopathological changes observed in the kidney after DDP alone or combined with WBH were primarily found in the proximal pars recta tubules (S3 segment) in the outer stripe of the outer medulla. There was no qualitative difference in tubular damage between rats treated with DDP alone or those treated with DDP combined with WBH. However, at a fixed DDP dose, damage in the combined treatment modality group was significantly greater than in the DDP-only treated group.</description><identifier>ISSN: 0008-5472</identifier><identifier>EISSN: 1538-7445</identifier><identifier>PMID: 3335012</identifier><identifier>CODEN: CNREA8</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Animals ; Biological and medical sciences ; Blood Urea Nitrogen ; Cisplatin - therapeutic use ; Cisplatin - toxicity ; Combined Modality Therapy ; Creatinine - blood ; Drug toxicity and drugs side effects treatment ; Female ; Fibrosarcoma - therapy ; Hyperthermia, Induced ; Kidney - drug effects ; Kidney - pathology ; Medical sciences ; Necrosis ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred F344 ; Time Factors ; Toxicity: urogenital system</subject><ispartof>Cancer research (Chicago, Ill.), 1988-01, Vol.48 (2), p.440-446</ispartof><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7593504$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3335012$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WONDERGEM, J</creatorcontrib><creatorcontrib>BULGER, R. E</creatorcontrib><creatorcontrib>STREBEL, F. R</creatorcontrib><creatorcontrib>NEWMAN, R. A</creatorcontrib><creatorcontrib>TRAVIS, E. L</creatorcontrib><creatorcontrib>STEPHENS, L. C</creatorcontrib><creatorcontrib>BULL, J. M. C</creatorcontrib><title>Effect of cis-diamminedichloroplatinum(II) combined with whole body hyperthermia on renal injury</title><title>Cancer research (Chicago, Ill.)</title><addtitle>Cancer Res</addtitle><description>The effect of whole body hyperthermia (WBH) on cis-diamminedichloroplatinum (II) (DDP) induced renal toxicity and antitumor effect was studied using a F344 rat model. Renal injury at 5 and 14 days after treatment was evaluated using animal mortality, renal functional assays (blood urea nitrogen, creatinine), and histopathological methods. WBH (120 min at 41.5 degrees C) enhanced both antitumor effects and toxic side effects. The latter included increased mortality, increased blood urea nitrogen and creatinine levels, and increased renal damage. After simultaneous treatment with WBH and DDP, thermal enhancement ratios (TER) for renal damage between 2.5 and 3.0 were calculated. The histopathological changes observed in the kidney after DDP alone or combined with WBH were primarily found in the proximal pars recta tubules (S3 segment) in the outer stripe of the outer medulla. There was no qualitative difference in tubular damage between rats treated with DDP alone or those treated with DDP combined with WBH. However, at a fixed DDP dose, damage in the combined treatment modality group was significantly greater than in the DDP-only treated group.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Urea Nitrogen</subject><subject>Cisplatin - therapeutic use</subject><subject>Cisplatin - toxicity</subject><subject>Combined Modality Therapy</subject><subject>Creatinine - blood</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Female</subject><subject>Fibrosarcoma - therapy</subject><subject>Hyperthermia, Induced</subject><subject>Kidney - drug effects</subject><subject>Kidney - pathology</subject><subject>Medical sciences</subject><subject>Necrosis</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Time Factors</subject><subject>Toxicity: urogenital system</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j8tKxDAARYMoYx39BCELF7oIpHm0zVKGcSwMuNH1mCfN0DQlbRn691Ysri6Xc7hwr0CWc1qhkjF-DTKMcYU4K8ktuBuG81J5jvkGbCilHOckA99756weYXRQ-wEZL0PwnTVeN21MsW_l6LspPNf1C9QxqF8GL35s4KWJrYUqmhk2c2_T2NgUvISxg8l2soW-O09pvgc3TraDfVhzC77e9p-7d3T8ONS71yNqSFGOqBBMM-G0LTUruDBEOI6NUFhVjDNTuFwZQQiRQhIupC7ykqhFUznjQjhKt-Dxb7efVLDm1CcfZJpP69OFP61cDlq2LsluOfyvlVwsHqM_P59d8Q</recordid><startdate>19880115</startdate><enddate>19880115</enddate><creator>WONDERGEM, J</creator><creator>BULGER, R. E</creator><creator>STREBEL, F. R</creator><creator>NEWMAN, R. A</creator><creator>TRAVIS, E. L</creator><creator>STEPHENS, L. C</creator><creator>BULL, J. M. C</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>19880115</creationdate><title>Effect of cis-diamminedichloroplatinum(II) combined with whole body hyperthermia on renal injury</title><author>WONDERGEM, J ; BULGER, R. E ; STREBEL, F. R ; NEWMAN, R. A ; TRAVIS, E. L ; STEPHENS, L. C ; BULL, J. M. C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h267t-694c49fce7c4659d29f50d9b0b8454d6f1bd9222a9a259ac6172b9d2b14599f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Urea Nitrogen</topic><topic>Cisplatin - therapeutic use</topic><topic>Cisplatin - toxicity</topic><topic>Combined Modality Therapy</topic><topic>Creatinine - blood</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Female</topic><topic>Fibrosarcoma - therapy</topic><topic>Hyperthermia, Induced</topic><topic>Kidney - drug effects</topic><topic>Kidney - pathology</topic><topic>Medical sciences</topic><topic>Necrosis</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Time Factors</topic><topic>Toxicity: urogenital system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WONDERGEM, J</creatorcontrib><creatorcontrib>BULGER, R. E</creatorcontrib><creatorcontrib>STREBEL, F. R</creatorcontrib><creatorcontrib>NEWMAN, R. A</creatorcontrib><creatorcontrib>TRAVIS, E. L</creatorcontrib><creatorcontrib>STEPHENS, L. C</creatorcontrib><creatorcontrib>BULL, J. M. C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Cancer research (Chicago, Ill.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WONDERGEM, J</au><au>BULGER, R. E</au><au>STREBEL, F. R</au><au>NEWMAN, R. A</au><au>TRAVIS, E. L</au><au>STEPHENS, L. C</au><au>BULL, J. M. C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of cis-diamminedichloroplatinum(II) combined with whole body hyperthermia on renal injury</atitle><jtitle>Cancer research (Chicago, Ill.)</jtitle><addtitle>Cancer Res</addtitle><date>1988-01-15</date><risdate>1988</risdate><volume>48</volume><issue>2</issue><spage>440</spage><epage>446</epage><pages>440-446</pages><issn>0008-5472</issn><eissn>1538-7445</eissn><coden>CNREA8</coden><abstract>The effect of whole body hyperthermia (WBH) on cis-diamminedichloroplatinum (II) (DDP) induced renal toxicity and antitumor effect was studied using a F344 rat model. Renal injury at 5 and 14 days after treatment was evaluated using animal mortality, renal functional assays (blood urea nitrogen, creatinine), and histopathological methods. WBH (120 min at 41.5 degrees C) enhanced both antitumor effects and toxic side effects. The latter included increased mortality, increased blood urea nitrogen and creatinine levels, and increased renal damage. After simultaneous treatment with WBH and DDP, thermal enhancement ratios (TER) for renal damage between 2.5 and 3.0 were calculated. The histopathological changes observed in the kidney after DDP alone or combined with WBH were primarily found in the proximal pars recta tubules (S3 segment) in the outer stripe of the outer medulla. There was no qualitative difference in tubular damage between rats treated with DDP alone or those treated with DDP combined with WBH. However, at a fixed DDP dose, damage in the combined treatment modality group was significantly greater than in the DDP-only treated group.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>3335012</pmid><tpages>7</tpages></addata></record> |
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| ispartof | Cancer research (Chicago, Ill.), 1988-01, Vol.48 (2), p.440-446 |
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| source | MEDLINE; American Association for Cancer Research; EZB Electronic Journals Library |
| subjects | Animals Biological and medical sciences Blood Urea Nitrogen Cisplatin - therapeutic use Cisplatin - toxicity Combined Modality Therapy Creatinine - blood Drug toxicity and drugs side effects treatment Female Fibrosarcoma - therapy Hyperthermia, Induced Kidney - drug effects Kidney - pathology Medical sciences Necrosis Pharmacology. Drug treatments Rats Rats, Inbred F344 Time Factors Toxicity: urogenital system |
| title | Effect of cis-diamminedichloroplatinum(II) combined with whole body hyperthermia on renal injury |
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