Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype

Glioblastoma frequently exhibits therapy-associated subtype transitions to mesenchymal phenotypes with adverse prognosis. Here, we perform multi-omic profiling of 60 glioblastoma primary tumours and use orthogonal analysis of chromatin and RNA-derived gene regulatory networks to identify 38 subtype...

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Veröffentlicht in:	Nature communications 2020-12, Vol.11 (1), p.6434-6434, Article 6434
Hauptverfasser:	Wu, Yonghe, Fletcher, Michael, Gu, Zuguang, Wang, Qi, Costa, Barbara, Bertoni, Anna, Man, Ka-Hou, Schlotter, Magdalena, Felsberg, Jörg, Mangei, Jasmin, Barbus, Martje, Gaupel, Ann-Christin, Wang, Wei, Weiss, Tobias, Eils, Roland, Weller, Michael, Liu, Haikun, Reifenberger, Guido, Korshunov, Andrey, Angel, Peter, Lichter, Peter, Herrmann, Carl, Radlwimmer, Bernhard
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 45 45/15 45/23 45/44 45/61 59/57 631/67/1922 631/67/69 64/60 Brain cancer Brain Neoplasms - classification Brain Neoplasms - genetics Cell Line, Tumor Chromatin DNA Methylation - genetics Enhancer Elements, Genetic - genetics Epigenetics Epigenome Female Gene expression Gene Expression Regulation, Neoplastic Gene sequencing Glioblastoma Glioblastoma - classification Glioblastoma - genetics Humanities and Social Sciences Humans Immune system Male Medical prognosis Mesenchyme Mesoderm - pathology Metastases Middle Aged multidisciplinary Multidisciplinary Sciences Phenotype Phenotypes Regulators Reproducibility of Results Ribonucleic acid RNA Science Science & Technology Science & Technology - Other Topics Science (multidisciplinary) Sox10 protein SOXE Transcription Factors - genetics SOXE Transcription Factors - metabolism Transcriptomics Tumors
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