Lab-in-a-pencil graphite: A 3D-printed microfluidic sensing platform for real-time measurement of antipsychotic clozapine level
A novel lab-in-a-pencil graphite microfluidic sensing electrode (μFSE) was fabricated for real-time flow injection measurement of the antipsychotic drug clozapine (Clz). A simple, low-cost, and reusable μFSE was obtained by using 3D printing of a microfluidic chamber integrated with a flat pencil gr...
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| Veröffentlicht in: | Lab on a chip 2021-01, Vol.21 (2), p.45-411 |
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| creator | Senel, Mehmet Alachkar, Amal |
| description | A novel lab-in-a-pencil graphite microfluidic sensing electrode (μFSE) was fabricated for real-time flow injection measurement of the antipsychotic drug clozapine (Clz). A simple, low-cost, and reusable μFSE was obtained by using 3D printing of a microfluidic chamber integrated with a flat pencil graphite without the need to utilize complex technologies. The μFSE has tubular geometry with 800 μm diameter, where the solution continuously flows in the holes of flat pencil graphite electrodes. Under optimized conditions, this device offers fast and effective Clz detection with good analytical features. A linear calibration curve in the range of 0.5 to 10 μM Clz was obtained with good sensitivity (0.01275 μA μM
−1
) and detection limit (24 nM). Finally, we demonstrate the applicability of our lab-fabricated microfluidic electrochemical device by monitoring Clz in serum samples at low concentrations.
A novel lab-in-a-pencil graphite microfluidic sensing electrode (μFSE) was fabricated for real-time flow injection measurement of the antipsychotic drug clozapine (Clz). |
| doi_str_mv | 10.1039/d0lc00970a |
| format | Article |
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−1
) and detection limit (24 nM). Finally, we demonstrate the applicability of our lab-fabricated microfluidic electrochemical device by monitoring Clz in serum samples at low concentrations.
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−1
) and detection limit (24 nM). Finally, we demonstrate the applicability of our lab-fabricated microfluidic electrochemical device by monitoring Clz in serum samples at low concentrations.
A novel lab-in-a-pencil graphite microfluidic sensing electrode (μFSE) was fabricated for real-time flow injection measurement of the antipsychotic drug clozapine (Clz).</description><subject>Diameters</subject><subject>Electrodes</subject><subject>Graphite</subject><subject>Low concentrations</subject><subject>Microfluidics</subject><subject>Psychotropic drugs</subject><subject>Real time</subject><subject>Three dimensional printing</subject><subject>Time measurement</subject><issn>1473-0197</issn><issn>1473-0189</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpd0c9rHCEUB3ApCU2a9pJ7itBLCdg-R3dm7G3Z_Cos9JL74DjPxOA4E3UK6SX_em033UI8qODHx-N9CTnl8IWDUF8H8AZANaDfkGMuG8GAt-pgf1fNEXmX0gMAX8m6fUuORFlcNO0xed7qnrnANJsxGOfpXdTzvcv4ja6puGBzdCHjQEdn4mT94gZnaMKQXLijs9fZTnGkZaMRtWfZjUhH1GmJOGLIdLJUh-zm9GTup1z-Gj_90rMLSD3-RP-eHFrtE354OU_I7dXl7eaGbX9cf9-st8xIUWfGoVGAwKWUaLEeKtS8qQbbNxUaVNCLVS9bwW3dghiMWXGpVhUXslZW4CBOyOdd2TlOjwum3I0uGfReB5yW1FWyAQWVFFWhn17Rh2mJoTRXVAuqlS2XRZ3vVBlLShFtVyY16vjUcej-pNJdwHbzN5V1wR9fSi79iMOe_ouhgLMdiMnsX__HKn4D_X6Rxg</recordid><startdate>20210121</startdate><enddate>20210121</enddate><creator>Senel, Mehmet</creator><creator>Alachkar, Amal</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7TB</scope><scope>7U5</scope><scope>8FD</scope><scope>FR3</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7366-4746</orcidid></search><sort><creationdate>20210121</creationdate><title>Lab-in-a-pencil graphite: A 3D-printed microfluidic sensing platform for real-time measurement of antipsychotic clozapine level</title><author>Senel, Mehmet ; Alachkar, Amal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-10790e01444efe6d2ea172dfb72ece90b35b4831f6803dcc51495213469f3ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Diameters</topic><topic>Electrodes</topic><topic>Graphite</topic><topic>Low concentrations</topic><topic>Microfluidics</topic><topic>Psychotropic drugs</topic><topic>Real time</topic><topic>Three dimensional printing</topic><topic>Time measurement</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Senel, Mehmet</creatorcontrib><creatorcontrib>Alachkar, Amal</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Lab on a chip</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Senel, Mehmet</au><au>Alachkar, Amal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lab-in-a-pencil graphite: A 3D-printed microfluidic sensing platform for real-time measurement of antipsychotic clozapine level</atitle><jtitle>Lab on a chip</jtitle><addtitle>Lab Chip</addtitle><date>2021-01-21</date><risdate>2021</risdate><volume>21</volume><issue>2</issue><spage>45</spage><epage>411</epage><pages>45-411</pages><issn>1473-0197</issn><eissn>1473-0189</eissn><abstract>A novel lab-in-a-pencil graphite microfluidic sensing electrode (μFSE) was fabricated for real-time flow injection measurement of the antipsychotic drug clozapine (Clz). A simple, low-cost, and reusable μFSE was obtained by using 3D printing of a microfluidic chamber integrated with a flat pencil graphite without the need to utilize complex technologies. The μFSE has tubular geometry with 800 μm diameter, where the solution continuously flows in the holes of flat pencil graphite electrodes. Under optimized conditions, this device offers fast and effective Clz detection with good analytical features. A linear calibration curve in the range of 0.5 to 10 μM Clz was obtained with good sensitivity (0.01275 μA μM
−1
) and detection limit (24 nM). Finally, we demonstrate the applicability of our lab-fabricated microfluidic electrochemical device by monitoring Clz in serum samples at low concentrations.
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| fulltext | fulltext |
| identifier | ISSN: 1473-0197 |
| ispartof | Lab on a chip, 2021-01, Vol.21 (2), p.45-411 |
| issn | 1473-0197 1473-0189 |
| language | eng |
| recordid | cdi_pubmed_primary_33331378 |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Diameters Electrodes Graphite Low concentrations Microfluidics Psychotropic drugs Real time Three dimensional printing Time measurement |
| title | Lab-in-a-pencil graphite: A 3D-printed microfluidic sensing platform for real-time measurement of antipsychotic clozapine level |
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