Antidepressant actions of ketamine engage cell-specific translation via eIF4E

Effective pharmacotherapy for major depressive disorder remains a major challenge, as more than 30% of patients are resistant to the first line of treatment (selective serotonin reuptake inhibitors) 1 . Sub-anaesthetic doses of ketamine, a non-competitive N -methyl- d -aspartate receptor antagonist...

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Veröffentlicht in:	Nature (London) 2021-02, Vol.590 (7845), p.315-319
Hauptverfasser:	Aguilar-Valles, Argel, De Gregorio, Danilo, Matta-Camacho, Edna, Eslamizade, Mohammad J., Khlaifia, Abdessattar, Skaleka, Agnieszka, Lopez-Canul, Martha, Torres-Berrio, Angelica, Bermudez, Sara, Rurak, Gareth M., Simard, Stephanie, Salmaso, Natalina, Gobbi, Gabriella, Lacaille, Jean-Claude, Sonenberg, Nahum
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 631/378/1689/1414 631/378/340 64 64/60 9/30 9/74 Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Antidepressants Antidepressive Agents - pharmacology Binding proteins Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Depression, Mental Depressive Disorder, Major - drug therapy Dosage and administration Drug therapy Eukaryotic Initiation Factor-4E - metabolism Eukaryotic Initiation Factors - genetics Eukaryotic Initiation Factors - metabolism Excitatory Postsynaptic Potentials - drug effects Gene deletion Glutamate receptors Health aspects Hippocampal plasticity Hippocampus Hippocampus - cytology Hippocampus - drug effects Hippocampus - metabolism Humanities and Social Sciences Inactivation Inhibitory Postsynaptic Potentials - drug effects Initiation factor eIF-4E Interneurons - drug effects Interneurons - metabolism Ketamine Ketamine - analogs & derivatives Ketamine - metabolism Ketamine - pharmacology Male Mechanistic Target of Rapamycin Complex 1 - metabolism Mental depression Metabolites Mice Mimicry mRNA multidisciplinary Multidisciplinary Sciences Mutation N-Methyl-D-aspartic acid receptors Neural Inhibition - drug effects Neural Inhibition - genetics Neurons Neurons - classification Neurons - cytology Neurons - drug effects Neurons - metabolism Neurotransmission Phosphorylation Protein Biosynthesis - drug effects Protein synthesis Proteins Pyramidal Cells - drug effects Pyramidal Cells - metabolism Rodents Science Science & Technology Science & Technology - Other Topics Science (multidisciplinary) Serotonin Serotonin uptake inhibitors Synaptic plasticity Synaptic Transmission - drug effects Translation initiation
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