Importance of lipids for upper motor neuron health and disease

Building evidence reveals the importance of maintaining lipid homeostasis for the health and function of neurons, and upper motor neurons (UMNs) are no exception. UMNs are critically important for the initiation and modulation of voluntary movement as they are responsible for conveying cerebral cort...

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Veröffentlicht in:	Seminars in cell & developmental biology 2021-04, Vol.112, p.92-104
Hauptverfasser:	Gunay, Aksu, Shin, Heather H., Gozutok, Oge, Gautam, Mukesh, Ozdinler, P. Hande
Format:	Artikel
Sprache:	eng
Schlagworte:	ALS Amyotrophic Lateral Sclerosis - genetics Amyotrophic Lateral Sclerosis - metabolism Amyotrophic Lateral Sclerosis - pathology Axons - metabolism Axons - pathology Betz cells Cerebral Cortex - metabolism Cerebral Cortex - pathology Corticospinal motor neurons Dendrites - genetics Dendrites - metabolism Dendrites - pathology ER, lipid homeostasis HSP Humans Lipid Metabolism - genetics Lipids - genetics Motor Neuron Disease - genetics Motor Neuron Disease - metabolism Motor Neuron Disease - pathology Motor Neurons - metabolism Motor Neurons - pathology PLS, mitochondria Spinal Cord - metabolism Spinal Cord - pathology
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