The Influence of Breastfeeding, Cesarean Section, Pet Animals, and Urbanization on the Development of Inflammatory Bowel Disease: Data from the Swiss IBD Cohort Study

The Influence of Breastfeeding, Cesarean Section, Pet Animals, and Urbanization on the Development of Inflammatory Bowel Disease: Data from the Swiss IBD Cohort Study

Introduction: The pathophysiology of inflammatory bowel disease (IBD) is incompletely understood. Current concepts imply that environmental factors (EFs) trigger disease onset as well as flares in genetically susceptible individuals. Objective: The objective of this study is to analyze the associati...

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Veröffentlicht in:Inflammatory intestinal diseases 2020-11, Vol.5 (4), p.170-179
Hauptverfasser: Lautenschlager, Severin A., Fournier, Nicolas, Biedermann, Luc, Pittet, Valerie, Schreiner, Philipp, Misselwitz, Benjamin, Scharl, Michael, Rogler, Gerhard, Siebenhüner, Alexander R.
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breastfeeding
crohn’s disease
environmental factors
inflammatory bowel disease
Research Article
swiss ibd cohort study
ulcerative colitis
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container_end_page 179
container_issue 4
container_start_page 170
container_title Inflammatory intestinal diseases
container_volume 5
creator Lautenschlager, Severin A.
Fournier, Nicolas
Biedermann, Luc
Pittet, Valerie
Schreiner, Philipp
Misselwitz, Benjamin
Scharl, Michael
Rogler, Gerhard
Siebenhüner, Alexander R.
description Introduction: The pathophysiology of inflammatory bowel disease (IBD) is incompletely understood. Current concepts imply that environmental factors (EFs) trigger disease onset as well as flares in genetically susceptible individuals. Objective: The objective of this study is to analyze the association between IBD and various EFs, which may influence the pathogenesis of the disease. Methods: 2,294 patients from the Swiss IBD Cohort Study (SIBDCS) received a questionnaire regarding EF including mode of delivery, breastfeeding, animals in household, and place of residence. The control group comprised patients’ childhood friends, who grew up in a similar environment (“friends cohort”). Results: A total of 1,111 questionnaires were returned from SIBDCS patients (response rate: 48.4%). Breastfeeding for
doi_str_mv 10.1159/000509058
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Current concepts imply that environmental factors (EFs) trigger disease onset as well as flares in genetically susceptible individuals. Objective: The objective of this study is to analyze the association between IBD and various EFs, which may influence the pathogenesis of the disease. Methods: 2,294 patients from the Swiss IBD Cohort Study (SIBDCS) received a questionnaire regarding EF including mode of delivery, breastfeeding, animals in household, and place of residence. The control group comprised patients’ childhood friends, who grew up in a similar environment (“friends cohort”). Results: A total of 1,111 questionnaires were returned from SIBDCS patients (response rate: 48.4%). Breastfeeding for &lt;6 months was associated with a decreased risk for ulcerative colitis/indeterminate colitis (UC/IC) (OR: 0.473, p = 0.006). IBD patients reported less pet animals in the household than the control group (p = 0.004). The presence of cats or dogs (OR: 0.688, p = 0.015) and pet rodents (OR: 0.598, p = 0.001) in the household before the age of 20 was inversely associated with the risk for UC/IC. Conclusion: The present study underlines the importance of EFs in the pathogenesis of IBD. Overall, the development of UC/IC seems to be more affected from environmental influences than from Crohn’s disease. Our results imply a protective effect of possessing pet animals in household and short breastfeeding regarding the onset of UC/IC.</description><identifier>ISSN: 2296-9403</identifier><identifier>EISSN: 2296-9365</identifier><identifier>DOI: 10.1159/000509058</identifier><identifier>PMID: 33313069</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>breastfeeding ; crohn’s disease ; environmental factors ; inflammatory bowel disease ; Research Article ; swiss ibd cohort study ; ulcerative colitis</subject><ispartof>Inflammatory intestinal diseases, 2020-11, Vol.5 (4), p.170-179</ispartof><rights>The Author(s). Published by S. Karger AG, Basel</rights><rights>Copyright © 2020 by S. Karger AG, Basel.</rights><rights>Copyright © 2020 by S. Karger AG, Basel 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4728-f75de069c8c3b1b3f6f0d187242767437abd4245703b3e2dcc7d34c30b03bd773</citedby><cites>FETCH-LOGICAL-c4728-f75de069c8c3b1b3f6f0d187242767437abd4245703b3e2dcc7d34c30b03bd773</cites><orcidid>0000-0002-8719-5175</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706488/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706488/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,27635,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33313069$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lautenschlager, Severin A.</creatorcontrib><creatorcontrib>Fournier, Nicolas</creatorcontrib><creatorcontrib>Biedermann, Luc</creatorcontrib><creatorcontrib>Pittet, Valerie</creatorcontrib><creatorcontrib>Schreiner, Philipp</creatorcontrib><creatorcontrib>Misselwitz, Benjamin</creatorcontrib><creatorcontrib>Scharl, Michael</creatorcontrib><creatorcontrib>Rogler, Gerhard</creatorcontrib><creatorcontrib>Siebenhüner, Alexander R.</creatorcontrib><creatorcontrib>on behalf of the Swiss IBD Cohort Study Group</creatorcontrib><title>The Influence of Breastfeeding, Cesarean Section, Pet Animals, and Urbanization on the Development of Inflammatory Bowel Disease: Data from the Swiss IBD Cohort Study</title><title>Inflammatory intestinal diseases</title><addtitle>Inflamm Intest Dis</addtitle><description>Introduction: The pathophysiology of inflammatory bowel disease (IBD) is incompletely understood. Current concepts imply that environmental factors (EFs) trigger disease onset as well as flares in genetically susceptible individuals. Objective: The objective of this study is to analyze the association between IBD and various EFs, which may influence the pathogenesis of the disease. Methods: 2,294 patients from the Swiss IBD Cohort Study (SIBDCS) received a questionnaire regarding EF including mode of delivery, breastfeeding, animals in household, and place of residence. The control group comprised patients’ childhood friends, who grew up in a similar environment (“friends cohort”). Results: A total of 1,111 questionnaires were returned from SIBDCS patients (response rate: 48.4%). Breastfeeding for &lt;6 months was associated with a decreased risk for ulcerative colitis/indeterminate colitis (UC/IC) (OR: 0.473, p = 0.006). IBD patients reported less pet animals in the household than the control group (p = 0.004). The presence of cats or dogs (OR: 0.688, p = 0.015) and pet rodents (OR: 0.598, p = 0.001) in the household before the age of 20 was inversely associated with the risk for UC/IC. Conclusion: The present study underlines the importance of EFs in the pathogenesis of IBD. Overall, the development of UC/IC seems to be more affected from environmental influences than from Crohn’s disease. Our results imply a protective effect of possessing pet animals in household and short breastfeeding regarding the onset of UC/IC.</description><subject>breastfeeding</subject><subject>crohn’s disease</subject><subject>environmental factors</subject><subject>inflammatory bowel disease</subject><subject>Research Article</subject><subject>swiss ibd cohort study</subject><subject>ulcerative colitis</subject><issn>2296-9403</issn><issn>2296-9365</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>M--</sourceid><sourceid>DOA</sourceid><recordid>eNptkltrFDEUgAdRbKl98F0k4IvCrmaSmclMH4TurpeBgsK2zyGXk210JlmTbMv6g_ydZrvtYkEIJJzz5Ts54RTFyxK_L8u6-4AxrnGH6_ZJcUxI10w72tRPH84VpkfFaYxWZopRUrfN8-KIUlpS3HTHxZ_La0C9M8MGnALkDZoFEDEZAG3daoLmEEWOOLQElax3E_QdEjp3dhRDnCDhNLoKUjj7W-zSKK-UlQu4gcGvR3BpJ91VEOMokg9bNPO3MKCFjbkQnKGFSAKZ4Me7i8tbGyPqZws099c-JLRMG719UTwzuR6c3u8nxdXnT5fzr9OLb1_6-fnFVFWMtFPDag25L9UqKktJTWOwLltGKsIaVlEmpK5IVTNMJQWilWKaVopimQOaMXpS9Huv9uIHX4fcZdhyLyy_C_iw4iIkqwbgShIqWy3bsoNKlkIqoIQyaoSoddmI7Pq4d603cgSt8lcEMTySPs44e81X_oYzhpuqbbPg7b0g-F8biImPNioYBuHAbyInFcOYdDWtM_puj6rgYwxgDmVKzHdjwg9jktnX_77rQD4MRQZe7YGfIqwgHIDD_Tf_Tff9Yk_wtTb0Ly67zjk</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Lautenschlager, Severin A.</creator><creator>Fournier, Nicolas</creator><creator>Biedermann, Luc</creator><creator>Pittet, Valerie</creator><creator>Schreiner, Philipp</creator><creator>Misselwitz, Benjamin</creator><creator>Scharl, Michael</creator><creator>Rogler, Gerhard</creator><creator>Siebenhüner, Alexander R.</creator><general>S. 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Current concepts imply that environmental factors (EFs) trigger disease onset as well as flares in genetically susceptible individuals. Objective: The objective of this study is to analyze the association between IBD and various EFs, which may influence the pathogenesis of the disease. Methods: 2,294 patients from the Swiss IBD Cohort Study (SIBDCS) received a questionnaire regarding EF including mode of delivery, breastfeeding, animals in household, and place of residence. The control group comprised patients’ childhood friends, who grew up in a similar environment (“friends cohort”). Results: A total of 1,111 questionnaires were returned from SIBDCS patients (response rate: 48.4%). Breastfeeding for &lt;6 months was associated with a decreased risk for ulcerative colitis/indeterminate colitis (UC/IC) (OR: 0.473, p = 0.006). IBD patients reported less pet animals in the household than the control group (p = 0.004). 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subjects breastfeeding
crohn’s disease
environmental factors
inflammatory bowel disease
Research Article
swiss ibd cohort study
ulcerative colitis
title The Influence of Breastfeeding, Cesarean Section, Pet Animals, and Urbanization on the Development of Inflammatory Bowel Disease: Data from the Swiss IBD Cohort Study
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