Co-localization of CD169+ macrophages and cancer cells in lymph node metastases of breast cancer patients is linked to improved prognosis and PDL1 expression
Breast cancer is the most common form of cancer in women worldwide. Although the survival among breast cancer patients has improved, there is still a large group of patients with dismal prognosis. One of the most important prognostic factors for poor prognosis is lymph node metastasis. Increasing kn...
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| Veröffentlicht in: | Oncoimmunology 2020-01, Vol.9 (1), p.1848067-1848067 |
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| creator | Björk Gunnarsdottir, Frida Auoja, Nathalie Bendahl, Pär-Ola Rydén, Lisa Fernö, Mårten Leandersson, Karin |
| description | Breast cancer is the most common form of cancer in women worldwide. Although the survival among breast cancer patients has improved, there is still a large group of patients with dismal prognosis. One of the most important prognostic factors for poor prognosis is lymph node metastasis. Increasing knowledge concerning the lymph nodes of breast cancer patients indicates that they are affected by the primary tumor. In this study we show that presence of CD169
+
subcapsular sinus macrophages in contact with lymph node metastases in breast cancer patients, is related to better prognosis after adjuvant tamoxifen treatment, but only in patients with PDL1
+
primary tumors. This is in contrast to the prognostic effect of CD169
+
primary tumor-associated macrophages (TAMs). We further show that CD169
+
macrophages were spatially associated with expression of PDL1 on nearby cells, both in primary tumors and metastatic lymph node, although PDL1 expression in metastatic lymph node as such did not have further prognostic impact. Our data suggest that CD169
+
resident lymph node macrophages have a unique function in targeting immune responses against breast cancer and should be further investigated in detail. |
| doi_str_mv | 10.1080/2162402X.2020.1848067 |
| format | Article |
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+
subcapsular sinus macrophages in contact with lymph node metastases in breast cancer patients, is related to better prognosis after adjuvant tamoxifen treatment, but only in patients with PDL1
+
primary tumors. This is in contrast to the prognostic effect of CD169
+
primary tumor-associated macrophages (TAMs). We further show that CD169
+
macrophages were spatially associated with expression of PDL1 on nearby cells, both in primary tumors and metastatic lymph node, although PDL1 expression in metastatic lymph node as such did not have further prognostic impact. Our data suggest that CD169
+
resident lymph node macrophages have a unique function in targeting immune responses against breast cancer and should be further investigated in detail.</description><identifier>ISSN: 2162-402X</identifier><identifier>ISSN: 2162-4011</identifier><identifier>EISSN: 2162-402X</identifier><identifier>DOI: 10.1080/2162402X.2020.1848067</identifier><identifier>PMID: 33299660</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>Breast cancer ; Cancer and Oncology ; Cancer och onkologi ; CD169 ; Clinical Medicine ; Klinisk medicin ; lymph node ; macrophage ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Original Research ; PDL1</subject><ispartof>Oncoimmunology, 2020-01, Vol.9 (1), p.1848067-1848067</ispartof><rights>2020 The Author(s). Published with license by Taylor & Francis Group, LLC. 2020</rights><rights>2020 The Author(s). Published with license by Taylor & Francis Group, LLC.</rights><rights>2020 The Author(s). Published with license by Taylor & Francis Group, LLC. 2020 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c669t-2eee2cd54de1bbed75ec92fceaaa25670643e7b11b719c57e0ddb0f7f045f8a43</citedby><cites>FETCH-LOGICAL-c669t-2eee2cd54de1bbed75ec92fceaaa25670643e7b11b719c57e0ddb0f7f045f8a43</cites><orcidid>0000-0001-8254-3137 ; 0000-0001-8862-1845 ; 0000-0002-2112-4382 ; 0000-0001-7515-3130</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7714471/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7714471/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,723,776,780,860,881,2096,27479,27901,27902,53766,53768,59116,59117</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33299660$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://lup.lub.lu.se/record/f4605cb6-e3f4-46a1-8c36-4dc9c43fb7c3$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Björk Gunnarsdottir, Frida</creatorcontrib><creatorcontrib>Auoja, Nathalie</creatorcontrib><creatorcontrib>Bendahl, Pär-Ola</creatorcontrib><creatorcontrib>Rydén, Lisa</creatorcontrib><creatorcontrib>Fernö, Mårten</creatorcontrib><creatorcontrib>Leandersson, Karin</creatorcontrib><title>Co-localization of CD169+ macrophages and cancer cells in lymph node metastases of breast cancer patients is linked to improved prognosis and PDL1 expression</title><title>Oncoimmunology</title><addtitle>Oncoimmunology</addtitle><description>Breast cancer is the most common form of cancer in women worldwide. Although the survival among breast cancer patients has improved, there is still a large group of patients with dismal prognosis. One of the most important prognostic factors for poor prognosis is lymph node metastasis. Increasing knowledge concerning the lymph nodes of breast cancer patients indicates that they are affected by the primary tumor. In this study we show that presence of CD169
+
subcapsular sinus macrophages in contact with lymph node metastases in breast cancer patients, is related to better prognosis after adjuvant tamoxifen treatment, but only in patients with PDL1
+
primary tumors. This is in contrast to the prognostic effect of CD169
+
primary tumor-associated macrophages (TAMs). We further show that CD169
+
macrophages were spatially associated with expression of PDL1 on nearby cells, both in primary tumors and metastatic lymph node, although PDL1 expression in metastatic lymph node as such did not have further prognostic impact. Our data suggest that CD169
+
resident lymph node macrophages have a unique function in targeting immune responses against breast cancer and should be further investigated in detail.</description><subject>Breast cancer</subject><subject>Cancer and Oncology</subject><subject>Cancer och onkologi</subject><subject>CD169</subject><subject>Clinical Medicine</subject><subject>Klinisk medicin</subject><subject>lymph node</subject><subject>macrophage</subject><subject>Medical and Health Sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Original Research</subject><subject>PDL1</subject><issn>2162-402X</issn><issn>2162-4011</issn><issn>2162-402X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>D8T</sourceid><sourceid>DOA</sourceid><recordid>eNp9kt9uFCEUxidGY5vaR9BwaWK2AsPAcGM0W_802UQvNPGOMHDYpc4MI8y2ru_iu3rWbZv2xgkEOHznd8icr6qeM3rGaEtfcya5oPz7GaccQ61oqVSPquN9fLG_eHxvf1SdlnJJ8ZO0kbV-Wh3VNddaSnpc_VmmRZ-c7eNvO8c0khTI8pxJ_YoM1uU0bewaCrGjJ86ODjJx0PeFxJH0u2HakDF5IAPMtuBAJeZ3GfB0q5-QC-OMKYX0cfwBnsyJxGHK6Qr3uKzHVOKhxpfzFSPwa8pQCr7mWfUk2L7A6c16Un378P7r8tNi9fnjxfLdauGk1POCAwB3vhEeWNeBVw04zYMDay1vpKJS1KA6xjrFtGsUUO87GlSgogmtFfVJdXHg-mQvzZTjYPPOJBvNv0DKa2PzHF0PxofQqk6LVthagAbdctG2XDdYlQdvkbU6sMo1TNvuAa3fTjg7nKaACQIb4jppoA7CCGmZaV0tjfBOO1GHTrkacW8OOGQN4B3-ymz7B9SHN2PcmHW6MkoxIRRDwMsbQE4_t1BmM8Syb6IdIW2L4UJqqljTKJQ2Byk2vpQM4a4Mo2ZvPHNrPLM3nrkxHua9uP_Gu6xbm6Hg7UEQx5DyYK9T7r2Z7a5POWT0SSym_n-Nv6aj65s</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Björk Gunnarsdottir, Frida</creator><creator>Auoja, Nathalie</creator><creator>Bendahl, Pär-Ola</creator><creator>Rydén, Lisa</creator><creator>Fernö, Mårten</creator><creator>Leandersson, Karin</creator><general>Taylor & Francis</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AGCHP</scope><scope>AOWAS</scope><scope>D8T</scope><scope>D95</scope><scope>ZZAVC</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-8254-3137</orcidid><orcidid>https://orcid.org/0000-0001-8862-1845</orcidid><orcidid>https://orcid.org/0000-0002-2112-4382</orcidid><orcidid>https://orcid.org/0000-0001-7515-3130</orcidid></search><sort><creationdate>20200101</creationdate><title>Co-localization of CD169+ macrophages and cancer cells in lymph node metastases of breast cancer patients is linked to improved prognosis and PDL1 expression</title><author>Björk Gunnarsdottir, Frida ; Auoja, Nathalie ; Bendahl, Pär-Ola ; Rydén, Lisa ; Fernö, Mårten ; Leandersson, Karin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c669t-2eee2cd54de1bbed75ec92fceaaa25670643e7b11b719c57e0ddb0f7f045f8a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Breast cancer</topic><topic>Cancer and Oncology</topic><topic>Cancer och onkologi</topic><topic>CD169</topic><topic>Clinical Medicine</topic><topic>Klinisk medicin</topic><topic>lymph node</topic><topic>macrophage</topic><topic>Medical and Health Sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Original Research</topic><topic>PDL1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Björk Gunnarsdottir, Frida</creatorcontrib><creatorcontrib>Auoja, Nathalie</creatorcontrib><creatorcontrib>Bendahl, Pär-Ola</creatorcontrib><creatorcontrib>Rydén, Lisa</creatorcontrib><creatorcontrib>Fernö, Mårten</creatorcontrib><creatorcontrib>Leandersson, Karin</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SWEPUB Lunds universitet full text</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Lunds universitet</collection><collection>SwePub Articles full text</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Oncoimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Björk Gunnarsdottir, Frida</au><au>Auoja, Nathalie</au><au>Bendahl, Pär-Ola</au><au>Rydén, Lisa</au><au>Fernö, Mårten</au><au>Leandersson, Karin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Co-localization of CD169+ macrophages and cancer cells in lymph node metastases of breast cancer patients is linked to improved prognosis and PDL1 expression</atitle><jtitle>Oncoimmunology</jtitle><addtitle>Oncoimmunology</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>9</volume><issue>1</issue><spage>1848067</spage><epage>1848067</epage><pages>1848067-1848067</pages><issn>2162-402X</issn><issn>2162-4011</issn><eissn>2162-402X</eissn><abstract>Breast cancer is the most common form of cancer in women worldwide. Although the survival among breast cancer patients has improved, there is still a large group of patients with dismal prognosis. One of the most important prognostic factors for poor prognosis is lymph node metastasis. Increasing knowledge concerning the lymph nodes of breast cancer patients indicates that they are affected by the primary tumor. In this study we show that presence of CD169
+
subcapsular sinus macrophages in contact with lymph node metastases in breast cancer patients, is related to better prognosis after adjuvant tamoxifen treatment, but only in patients with PDL1
+
primary tumors. This is in contrast to the prognostic effect of CD169
+
primary tumor-associated macrophages (TAMs). We further show that CD169
+
macrophages were spatially associated with expression of PDL1 on nearby cells, both in primary tumors and metastatic lymph node, although PDL1 expression in metastatic lymph node as such did not have further prognostic impact. Our data suggest that CD169
+
resident lymph node macrophages have a unique function in targeting immune responses against breast cancer and should be further investigated in detail.</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>33299660</pmid><doi>10.1080/2162402X.2020.1848067</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-8254-3137</orcidid><orcidid>https://orcid.org/0000-0001-8862-1845</orcidid><orcidid>https://orcid.org/0000-0002-2112-4382</orcidid><orcidid>https://orcid.org/0000-0001-7515-3130</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Taylor & Francis Open Access; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SWEPUB Freely available online |
| subjects | Breast cancer Cancer and Oncology Cancer och onkologi CD169 Clinical Medicine Klinisk medicin lymph node macrophage Medical and Health Sciences Medicin och hälsovetenskap Original Research PDL1 |
| title | Co-localization of CD169+ macrophages and cancer cells in lymph node metastases of breast cancer patients is linked to improved prognosis and PDL1 expression |
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