Pretransplant Cytomegalovirus-Specific Cellular Immunity and Risk of Viral Reactivation Following Lung Transplantation: A Prospective Cohort Study
Abstract Cytomegalovirus (CMV) remains a significant burden in lung transplant recipients. Deficiencies in T-cell immunity posttransplant increase the risk of CMV-associated complications. However, it is not clear if underlying poor pretransplant immunity increases risk. To assess this, we recruited...
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| Veröffentlicht in: | The Journal of infectious diseases 2021-07, Vol.224 (2), p.312-317 |
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| creator | Altaf, Mohammed Lineburg, Katie E Crooks, Pauline Rehan, Sweera Matthews, Katherine K Neller, Michelle A Ambalathingal, George R Sinha, Debottam Grant, Michelle Hopkins, Peter M A Chambers, Daniel Khanna, Rajiv Smith, Corey |
| description | Abstract
Cytomegalovirus (CMV) remains a significant burden in lung transplant recipients. Deficiencies in T-cell immunity posttransplant increase the risk of CMV-associated complications. However, it is not clear if underlying poor pretransplant immunity increases risk. To assess this, we recruited 39 prospective lung transplant patients and performed QuantiFERON-CMV on their peripheral blood. More than a third of prospective CMV-seropositive transplant recipients were CMV non-immune reactive (CMV-NIR) pretransplant. CMV-NIR status was associated with a significantly higher incidence of CMV reactivation posttransplant, demonstrating that dysfunctional CMV immunity in prospective lung transplant recipients is associated with an increased risk of viral reactivation posttransplant. |
| doi_str_mv | 10.1093/infdis/jiaa750 |
| format | Article |
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Cytomegalovirus (CMV) remains a significant burden in lung transplant recipients. Deficiencies in T-cell immunity posttransplant increase the risk of CMV-associated complications. However, it is not clear if underlying poor pretransplant immunity increases risk. To assess this, we recruited 39 prospective lung transplant patients and performed QuantiFERON-CMV on their peripheral blood. More than a third of prospective CMV-seropositive transplant recipients were CMV non-immune reactive (CMV-NIR) pretransplant. CMV-NIR status was associated with a significantly higher incidence of CMV reactivation posttransplant, demonstrating that dysfunctional CMV immunity in prospective lung transplant recipients is associated with an increased risk of viral reactivation posttransplant.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jiaa750</identifier><identifier>PMID: 33274385</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Cell-mediated immunity ; Cohort analysis ; Cytomegalovirus ; Cytomegalovirus Infections - epidemiology ; Cytomegalovirus Infections - immunology ; Humans ; Immunity, Cellular ; Immunocompetence ; Immunology ; Infectious Diseases ; Latent Infection - virology ; Life Sciences & Biomedicine ; Lung transplantation ; Lung Transplantation - adverse effects ; Lung transplants ; Lymphocytes T ; Microbiology ; Peripheral blood ; Prospective Studies ; Science & Technology</subject><ispartof>The Journal of infectious diseases, 2021-07, Vol.224 (2), p.312-317</ispartof><rights>The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. 2020</rights><rights>The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>7</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000693671600015</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c397t-ff70bbb8c910442cc2dd86467de1c13ca24310532c77397337daaa44ca224a343</citedby><cites>FETCH-LOGICAL-c397t-ff70bbb8c910442cc2dd86467de1c13ca24310532c77397337daaa44ca224a343</cites><orcidid>0000-0002-7550-9595 ; 0000-0002-4402-451X ; 0000-0003-2241-0353 ; 0000-0001-7153-856X ; 0000-0002-5712-2610 ; 0000-0002-9553-5870</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932,39265</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33274385$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Altaf, Mohammed</creatorcontrib><creatorcontrib>Lineburg, Katie E</creatorcontrib><creatorcontrib>Crooks, Pauline</creatorcontrib><creatorcontrib>Rehan, Sweera</creatorcontrib><creatorcontrib>Matthews, Katherine K</creatorcontrib><creatorcontrib>Neller, Michelle A</creatorcontrib><creatorcontrib>Ambalathingal, George R</creatorcontrib><creatorcontrib>Sinha, Debottam</creatorcontrib><creatorcontrib>Grant, Michelle</creatorcontrib><creatorcontrib>Hopkins, Peter M A</creatorcontrib><creatorcontrib>Chambers, Daniel</creatorcontrib><creatorcontrib>Khanna, Rajiv</creatorcontrib><creatorcontrib>Smith, Corey</creatorcontrib><title>Pretransplant Cytomegalovirus-Specific Cellular Immunity and Risk of Viral Reactivation Following Lung Transplantation: A Prospective Cohort Study</title><title>The Journal of infectious diseases</title><addtitle>J INFECT DIS</addtitle><addtitle>J Infect Dis</addtitle><description>Abstract
Cytomegalovirus (CMV) remains a significant burden in lung transplant recipients. Deficiencies in T-cell immunity posttransplant increase the risk of CMV-associated complications. However, it is not clear if underlying poor pretransplant immunity increases risk. To assess this, we recruited 39 prospective lung transplant patients and performed QuantiFERON-CMV on their peripheral blood. More than a third of prospective CMV-seropositive transplant recipients were CMV non-immune reactive (CMV-NIR) pretransplant. CMV-NIR status was associated with a significantly higher incidence of CMV reactivation posttransplant, demonstrating that dysfunctional CMV immunity in prospective lung transplant recipients is associated with an increased risk of viral reactivation posttransplant.</description><subject>Cell-mediated immunity</subject><subject>Cohort analysis</subject><subject>Cytomegalovirus</subject><subject>Cytomegalovirus Infections - epidemiology</subject><subject>Cytomegalovirus Infections - immunology</subject><subject>Humans</subject><subject>Immunity, Cellular</subject><subject>Immunocompetence</subject><subject>Immunology</subject><subject>Infectious Diseases</subject><subject>Latent Infection - virology</subject><subject>Life Sciences & Biomedicine</subject><subject>Lung transplantation</subject><subject>Lung Transplantation - adverse effects</subject><subject>Lung transplants</subject><subject>Lymphocytes T</subject><subject>Microbiology</subject><subject>Peripheral blood</subject><subject>Prospective Studies</subject><subject>Science & Technology</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><recordid>eNqNkUtv1DAUhS0EokNhyxJZYgOq0voVO2FXRRQqjdSqLWwjx3GKh8RO_Wg1f4NfjEuGWbApkmVbut85vtcHgLcYHWNU0xNjh96Ek42RUpToGVjhkoqCc0yfgxVChBS4qusD8CqEDUKIUS5eggNKiWC0Klfg16XX0Usb5lHaCJttdJO-laO7Nz6F4nrWygxGwUaPYxqlh-fTlKyJWyhtD69M-AndAL8bL0d4paWK5l5G4yw8c-PoHoy9heuUt5v9G3_Kn-ApvPQuZPus0LBxP5yP8DqmfvsavBjkGPSb3XkIvp19vmm-FuuLL-fN6bpQtBaxGAaBuq6rVI0RY0Qp0vcVZ1z0GitMlSSMYlRSooTIAkpFL6VkLBcIk5TRQ_Bh8Z29u0s6xHYyQeU5pdUuhZZkL45LXuGMvv8H3bjkbe6uJaXIi9cEZep4oVSeLHg9tLM3k_TbFqP2Ma12SavdpZUF73a2qZt0v8f_xpOBagEedOeGoIy2Su-xnCevc6CY5xsuG7P8beOSjVl69P_STH9caJfmp7r-DbRLw_E</recordid><startdate>20210715</startdate><enddate>20210715</enddate><creator>Altaf, Mohammed</creator><creator>Lineburg, Katie E</creator><creator>Crooks, Pauline</creator><creator>Rehan, Sweera</creator><creator>Matthews, Katherine K</creator><creator>Neller, Michelle A</creator><creator>Ambalathingal, George R</creator><creator>Sinha, Debottam</creator><creator>Grant, Michelle</creator><creator>Hopkins, Peter M A</creator><creator>Chambers, Daniel</creator><creator>Khanna, Rajiv</creator><creator>Smith, Corey</creator><general>Oxford University Press</general><general>Oxford Univ Press</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7550-9595</orcidid><orcidid>https://orcid.org/0000-0002-4402-451X</orcidid><orcidid>https://orcid.org/0000-0003-2241-0353</orcidid><orcidid>https://orcid.org/0000-0001-7153-856X</orcidid><orcidid>https://orcid.org/0000-0002-5712-2610</orcidid><orcidid>https://orcid.org/0000-0002-9553-5870</orcidid></search><sort><creationdate>20210715</creationdate><title>Pretransplant Cytomegalovirus-Specific Cellular Immunity and Risk of Viral Reactivation Following Lung Transplantation: A Prospective Cohort Study</title><author>Altaf, Mohammed ; Lineburg, Katie E ; Crooks, Pauline ; Rehan, Sweera ; Matthews, Katherine K ; Neller, Michelle A ; Ambalathingal, George R ; Sinha, Debottam ; Grant, Michelle ; Hopkins, Peter M A ; Chambers, Daniel ; Khanna, Rajiv ; Smith, Corey</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c397t-ff70bbb8c910442cc2dd86467de1c13ca24310532c77397337daaa44ca224a343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cell-mediated immunity</topic><topic>Cohort analysis</topic><topic>Cytomegalovirus</topic><topic>Cytomegalovirus Infections - epidemiology</topic><topic>Cytomegalovirus Infections - immunology</topic><topic>Humans</topic><topic>Immunity, Cellular</topic><topic>Immunocompetence</topic><topic>Immunology</topic><topic>Infectious Diseases</topic><topic>Latent Infection - virology</topic><topic>Life Sciences & Biomedicine</topic><topic>Lung transplantation</topic><topic>Lung Transplantation - adverse effects</topic><topic>Lung transplants</topic><topic>Lymphocytes T</topic><topic>Microbiology</topic><topic>Peripheral blood</topic><topic>Prospective Studies</topic><topic>Science & Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Altaf, Mohammed</creatorcontrib><creatorcontrib>Lineburg, Katie E</creatorcontrib><creatorcontrib>Crooks, Pauline</creatorcontrib><creatorcontrib>Rehan, Sweera</creatorcontrib><creatorcontrib>Matthews, Katherine K</creatorcontrib><creatorcontrib>Neller, Michelle A</creatorcontrib><creatorcontrib>Ambalathingal, George R</creatorcontrib><creatorcontrib>Sinha, Debottam</creatorcontrib><creatorcontrib>Grant, Michelle</creatorcontrib><creatorcontrib>Hopkins, Peter M A</creatorcontrib><creatorcontrib>Chambers, Daniel</creatorcontrib><creatorcontrib>Khanna, Rajiv</creatorcontrib><creatorcontrib>Smith, Corey</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Altaf, Mohammed</au><au>Lineburg, Katie E</au><au>Crooks, Pauline</au><au>Rehan, Sweera</au><au>Matthews, Katherine K</au><au>Neller, Michelle A</au><au>Ambalathingal, George R</au><au>Sinha, Debottam</au><au>Grant, Michelle</au><au>Hopkins, Peter M A</au><au>Chambers, Daniel</au><au>Khanna, Rajiv</au><au>Smith, Corey</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pretransplant Cytomegalovirus-Specific Cellular Immunity and Risk of Viral Reactivation Following Lung Transplantation: A Prospective Cohort Study</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>J INFECT DIS</stitle><addtitle>J Infect Dis</addtitle><date>2021-07-15</date><risdate>2021</risdate><volume>224</volume><issue>2</issue><spage>312</spage><epage>317</epage><pages>312-317</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>Abstract
Cytomegalovirus (CMV) remains a significant burden in lung transplant recipients. Deficiencies in T-cell immunity posttransplant increase the risk of CMV-associated complications. However, it is not clear if underlying poor pretransplant immunity increases risk. To assess this, we recruited 39 prospective lung transplant patients and performed QuantiFERON-CMV on their peripheral blood. More than a third of prospective CMV-seropositive transplant recipients were CMV non-immune reactive (CMV-NIR) pretransplant. CMV-NIR status was associated with a significantly higher incidence of CMV reactivation posttransplant, demonstrating that dysfunctional CMV immunity in prospective lung transplant recipients is associated with an increased risk of viral reactivation posttransplant.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>33274385</pmid><doi>10.1093/infdis/jiaa750</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-7550-9595</orcidid><orcidid>https://orcid.org/0000-0002-4402-451X</orcidid><orcidid>https://orcid.org/0000-0003-2241-0353</orcidid><orcidid>https://orcid.org/0000-0001-7153-856X</orcidid><orcidid>https://orcid.org/0000-0002-5712-2610</orcidid><orcidid>https://orcid.org/0000-0002-9553-5870</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Cell-mediated immunity Cohort analysis Cytomegalovirus Cytomegalovirus Infections - epidemiology Cytomegalovirus Infections - immunology Humans Immunity, Cellular Immunocompetence Immunology Infectious Diseases Latent Infection - virology Life Sciences & Biomedicine Lung transplantation Lung Transplantation - adverse effects Lung transplants Lymphocytes T Microbiology Peripheral blood Prospective Studies Science & Technology |
| title | Pretransplant Cytomegalovirus-Specific Cellular Immunity and Risk of Viral Reactivation Following Lung Transplantation: A Prospective Cohort Study |
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