Diagnostic and prognostic significance of aberrant miR-652-3p levels in patients with acute decompensated heart failure and acute kidney injury
Objective This study aimed to examine a novel microRNA (miR-652-3p) biomarker to improve early diagnosis of acute kidney injury (AKI) in patients with acute decompensated heart failure (ADHF) and to evaluate the survival predictive value of miR-652-3p. Methods We retrospectively analyzed the data of...
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| Veröffentlicht in: | Journal of international medical research 2020-11, Vol.48 (11), p.1-12, Article 0300060520967829 |
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| creator | Liu, Jiaolei Zhang, Hongmei Li, Xin Wang, Lin Yu, Huining Huang, Jiaohong Liu, Qingjun Wang, Chao Jiang, Aili |
| description | Objective
This study aimed to examine a novel microRNA (miR-652-3p) biomarker to improve early diagnosis of acute kidney injury (AKI) in patients with acute decompensated heart failure (ADHF) and to evaluate the survival predictive value of miR-652-3p.
Methods
We retrospectively analyzed the data of 196 patients with ADHF, including 65 who developed AKI during hospitalization. Neutrophil gelatinase-associated lipocalin (NGAL) levels were measured in serum and urine samples. Real-time quantitative PCR was applied to evaluate miR-652-3p mRNA expression. The diagnostic performance of miR-652-3p was examined using receiver operating characteristic curve analysis. The prognostic value of miR-652-3p was also analyzed.
Results
Serum and urinary NGAL and miR-652-3p levels were elevated in patients with ADHF and AKI. Serum and urinary miR-652-3p expression had diagnostic value in predicting AKI onset in patients with ADHF, and it had improved diagnostic performance when used with NGAL. Patients with AKI and high miR-652-3p levels had a high failure rate of renal recovery and poor 180-day survival.
Conclusion
Serum and urinary miR-652-3p may be a candidate biomarker for early diagnosis of AKI in patients with ADHF and for predicting the prognosis of AKI. The combination of NGAL and miR-652-3p may accurately predict AKI onset in ADHF. |
| doi_str_mv | 10.1177/0300060520967829 |
| format | Article |
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This study aimed to examine a novel microRNA (miR-652-3p) biomarker to improve early diagnosis of acute kidney injury (AKI) in patients with acute decompensated heart failure (ADHF) and to evaluate the survival predictive value of miR-652-3p.
Methods
We retrospectively analyzed the data of 196 patients with ADHF, including 65 who developed AKI during hospitalization. Neutrophil gelatinase-associated lipocalin (NGAL) levels were measured in serum and urine samples. Real-time quantitative PCR was applied to evaluate miR-652-3p mRNA expression. The diagnostic performance of miR-652-3p was examined using receiver operating characteristic curve analysis. The prognostic value of miR-652-3p was also analyzed.
Results
Serum and urinary NGAL and miR-652-3p levels were elevated in patients with ADHF and AKI. Serum and urinary miR-652-3p expression had diagnostic value in predicting AKI onset in patients with ADHF, and it had improved diagnostic performance when used with NGAL. Patients with AKI and high miR-652-3p levels had a high failure rate of renal recovery and poor 180-day survival.
Conclusion
Serum and urinary miR-652-3p may be a candidate biomarker for early diagnosis of AKI in patients with ADHF and for predicting the prognosis of AKI. The combination of NGAL and miR-652-3p may accurately predict AKI onset in ADHF.</description><identifier>ISSN: 0300-0605</identifier><identifier>EISSN: 1473-2300</identifier><identifier>DOI: 10.1177/0300060520967829</identifier><identifier>PMID: 33249927</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Acute Kidney Injury - diagnosis ; Acute Kidney Injury - genetics ; Acute-Phase Proteins ; Biomarkers ; Heart failure ; Heart Failure - diagnosis ; Heart Failure - genetics ; Humans ; Kidneys ; Life Sciences & Biomedicine ; Lipocalins ; Medical prognosis ; Medicine, Research & Experimental ; MicroRNAs - genetics ; Pharmacology & Pharmacy ; Predictive Value of Tests ; Prognosis ; Proto-Oncogene Proteins ; Research & Experimental Medicine ; Retrospective Clinical Research Report ; Retrospective Studies ; Science & Technology</subject><ispartof>Journal of international medical research, 2020-11, Vol.48 (11), p.1-12, Article 0300060520967829</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is licensed under the Creative Commons Attribution – Non-Commercial License https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2020 2020 SAGE Publications</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>12</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000596407900001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c528t-cac3b9e7b774e0dbcca5b43851712817f2103c7576f2cb3bfe8557bb1eb2865c3</citedby><cites>FETCH-LOGICAL-c528t-cac3b9e7b774e0dbcca5b43851712817f2103c7576f2cb3bfe8557bb1eb2865c3</cites><orcidid>0000-0003-4828-7429</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708706/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708706/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2115,21971,27858,27929,27930,28253,44950,45338,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33249927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Jiaolei</creatorcontrib><creatorcontrib>Zhang, Hongmei</creatorcontrib><creatorcontrib>Li, Xin</creatorcontrib><creatorcontrib>Wang, Lin</creatorcontrib><creatorcontrib>Yu, Huining</creatorcontrib><creatorcontrib>Huang, Jiaohong</creatorcontrib><creatorcontrib>Liu, Qingjun</creatorcontrib><creatorcontrib>Wang, Chao</creatorcontrib><creatorcontrib>Jiang, Aili</creatorcontrib><title>Diagnostic and prognostic significance of aberrant miR-652-3p levels in patients with acute decompensated heart failure and acute kidney injury</title><title>Journal of international medical research</title><addtitle>J INT MED RES</addtitle><addtitle>J Int Med Res</addtitle><description>Objective
This study aimed to examine a novel microRNA (miR-652-3p) biomarker to improve early diagnosis of acute kidney injury (AKI) in patients with acute decompensated heart failure (ADHF) and to evaluate the survival predictive value of miR-652-3p.
Methods
We retrospectively analyzed the data of 196 patients with ADHF, including 65 who developed AKI during hospitalization. Neutrophil gelatinase-associated lipocalin (NGAL) levels were measured in serum and urine samples. Real-time quantitative PCR was applied to evaluate miR-652-3p mRNA expression. The diagnostic performance of miR-652-3p was examined using receiver operating characteristic curve analysis. The prognostic value of miR-652-3p was also analyzed.
Results
Serum and urinary NGAL and miR-652-3p levels were elevated in patients with ADHF and AKI. Serum and urinary miR-652-3p expression had diagnostic value in predicting AKI onset in patients with ADHF, and it had improved diagnostic performance when used with NGAL. Patients with AKI and high miR-652-3p levels had a high failure rate of renal recovery and poor 180-day survival.
Conclusion
Serum and urinary miR-652-3p may be a candidate biomarker for early diagnosis of AKI in patients with ADHF and for predicting the prognosis of AKI. The combination of NGAL and miR-652-3p may accurately predict AKI onset in ADHF.</description><subject>Acute Kidney Injury - diagnosis</subject><subject>Acute Kidney Injury - genetics</subject><subject>Acute-Phase Proteins</subject><subject>Biomarkers</subject><subject>Heart failure</subject><subject>Heart Failure - diagnosis</subject><subject>Heart Failure - genetics</subject><subject>Humans</subject><subject>Kidneys</subject><subject>Life Sciences & Biomedicine</subject><subject>Lipocalins</subject><subject>Medical prognosis</subject><subject>Medicine, Research & Experimental</subject><subject>MicroRNAs - genetics</subject><subject>Pharmacology & Pharmacy</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Proto-Oncogene Proteins</subject><subject>Research & Experimental Medicine</subject><subject>Retrospective Clinical Research Report</subject><subject>Retrospective Studies</subject><subject>Science & Technology</subject><issn>0300-0605</issn><issn>1473-2300</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNqNkltrFDEUgAdR7Fp990kCvggymstkMnkRynorFATR5yGXM7tZZ5M1ybTsr_Avm-20qy0IPuVyvvPlJDlV9ZzgN4QI8RYzjHGLOcWyFR2VD6oFaQSradl_WC0O4foQP6mepLTBuKEtp4-rE8ZoIyUVi-rXe6dWPqTsDFLeol0Mt8vkVt4NzihvAIUBKQ0xKp_R1n2ti6dmOzTCJYwJOY92KjvwOaErl9dImSkDsmDCdgc-qQwWrUHFjAblxinC9WEz9cNZD_vi2Exx_7R6NKgxwbOb8bT6_vHDt-Xn-uLLp_Pl2UVtOO1ybZRhWoLQQjSArTZGcd2wjhNBaEfEQAlmRnDRDtRopgfoOBdaE9C0a7lhp9X57LVBbfpddFsV931Qrr_eCHHVl2qdGaHvQA7SGqbM0DbCam2ItEJIpTppLRfF9W527Sa9BWvKM0Q13pHejXi37lfhshcCdwK3RfDqRhDDzwlS7rcuGRhH5SFMqadNywXnkrKCvryHbsIUfXmqA9VizEh7oPBMmRhSijAciyG4P3ROf79zSsqLvy9xTLhtlQK8noEr0GFIpvy2gSNWbFy2DRayzDApdPf_9NLl0j3BL8Pkc0mt59SkVvDnev-s_Dfxju6X</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Liu, Jiaolei</creator><creator>Zhang, Hongmei</creator><creator>Li, Xin</creator><creator>Wang, Lin</creator><creator>Yu, Huining</creator><creator>Huang, Jiaohong</creator><creator>Liu, Qingjun</creator><creator>Wang, Chao</creator><creator>Jiang, Aili</creator><general>SAGE Publications</general><general>Sage</general><general>Sage Publications Ltd</general><general>SAGE Publishing</general><scope>AFRWT</scope><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-4828-7429</orcidid></search><sort><creationdate>20201101</creationdate><title>Diagnostic and prognostic significance of aberrant miR-652-3p levels in patients with acute decompensated heart failure and acute kidney injury</title><author>Liu, Jiaolei ; Zhang, Hongmei ; Li, Xin ; Wang, Lin ; Yu, Huining ; Huang, Jiaohong ; Liu, Qingjun ; Wang, Chao ; Jiang, Aili</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c528t-cac3b9e7b774e0dbcca5b43851712817f2103c7576f2cb3bfe8557bb1eb2865c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acute Kidney Injury - diagnosis</topic><topic>Acute Kidney Injury - genetics</topic><topic>Acute-Phase Proteins</topic><topic>Biomarkers</topic><topic>Heart failure</topic><topic>Heart Failure - diagnosis</topic><topic>Heart Failure - genetics</topic><topic>Humans</topic><topic>Kidneys</topic><topic>Life Sciences & Biomedicine</topic><topic>Lipocalins</topic><topic>Medical prognosis</topic><topic>Medicine, Research & Experimental</topic><topic>MicroRNAs - genetics</topic><topic>Pharmacology & Pharmacy</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Proto-Oncogene Proteins</topic><topic>Research & Experimental Medicine</topic><topic>Retrospective Clinical Research Report</topic><topic>Retrospective Studies</topic><topic>Science & Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Jiaolei</creatorcontrib><creatorcontrib>Zhang, Hongmei</creatorcontrib><creatorcontrib>Li, Xin</creatorcontrib><creatorcontrib>Wang, Lin</creatorcontrib><creatorcontrib>Yu, Huining</creatorcontrib><creatorcontrib>Huang, Jiaohong</creatorcontrib><creatorcontrib>Liu, Qingjun</creatorcontrib><creatorcontrib>Wang, Chao</creatorcontrib><creatorcontrib>Jiang, Aili</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of international medical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Jiaolei</au><au>Zhang, Hongmei</au><au>Li, Xin</au><au>Wang, Lin</au><au>Yu, Huining</au><au>Huang, Jiaohong</au><au>Liu, Qingjun</au><au>Wang, Chao</au><au>Jiang, Aili</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic and prognostic significance of aberrant miR-652-3p levels in patients with acute decompensated heart failure and acute kidney injury</atitle><jtitle>Journal of international medical research</jtitle><stitle>J INT MED RES</stitle><addtitle>J Int Med Res</addtitle><date>2020-11-01</date><risdate>2020</risdate><volume>48</volume><issue>11</issue><spage>1</spage><epage>12</epage><pages>1-12</pages><artnum>0300060520967829</artnum><issn>0300-0605</issn><eissn>1473-2300</eissn><abstract>Objective
This study aimed to examine a novel microRNA (miR-652-3p) biomarker to improve early diagnosis of acute kidney injury (AKI) in patients with acute decompensated heart failure (ADHF) and to evaluate the survival predictive value of miR-652-3p.
Methods
We retrospectively analyzed the data of 196 patients with ADHF, including 65 who developed AKI during hospitalization. Neutrophil gelatinase-associated lipocalin (NGAL) levels were measured in serum and urine samples. Real-time quantitative PCR was applied to evaluate miR-652-3p mRNA expression. The diagnostic performance of miR-652-3p was examined using receiver operating characteristic curve analysis. The prognostic value of miR-652-3p was also analyzed.
Results
Serum and urinary NGAL and miR-652-3p levels were elevated in patients with ADHF and AKI. Serum and urinary miR-652-3p expression had diagnostic value in predicting AKI onset in patients with ADHF, and it had improved diagnostic performance when used with NGAL. Patients with AKI and high miR-652-3p levels had a high failure rate of renal recovery and poor 180-day survival.
Conclusion
Serum and urinary miR-652-3p may be a candidate biomarker for early diagnosis of AKI in patients with ADHF and for predicting the prognosis of AKI. The combination of NGAL and miR-652-3p may accurately predict AKI onset in ADHF.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>33249927</pmid><doi>10.1177/0300060520967829</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-4828-7429</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acute Kidney Injury - diagnosis Acute Kidney Injury - genetics Acute-Phase Proteins Biomarkers Heart failure Heart Failure - diagnosis Heart Failure - genetics Humans Kidneys Life Sciences & Biomedicine Lipocalins Medical prognosis Medicine, Research & Experimental MicroRNAs - genetics Pharmacology & Pharmacy Predictive Value of Tests Prognosis Proto-Oncogene Proteins Research & Experimental Medicine Retrospective Clinical Research Report Retrospective Studies Science & Technology |
| title | Diagnostic and prognostic significance of aberrant miR-652-3p levels in patients with acute decompensated heart failure and acute kidney injury |
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