STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells

Alternative splicing (AS) is involved in cell fate decisions and embryonic development. However, regulation of these processes is poorly understood. Here, we have identified the serine threonine kinase receptor-associated protein (STRAP) as a putative spliceosome-associated factor. Upon Strap deleti...

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Veröffentlicht in:	Nature communications 2020-11, Vol.11 (1), p.5941-5941, Article 5941
Hauptverfasser:	Jin, Lin, Chen, Yunjia, Crossman, David K., Datta, Arunima, Vu, Trung, Mobley, James A., Basu, Malay Kumar, Scarduzio, Mariangela, Wang, Hengbin, Chang, Chenbei, Datta, Pran K.
Format:	Artikel
Sprache:	eng
Schlagworte:	38/39 38/71 38/89 49/91 631/136/2060/368/2430 631/136/532/1360 631/337/1645/1792 631/337/572 631/532 82/58 Alternative Splicing Animals Binding Cell Differentiation - genetics Cell fate Cell lineage Cell Lineage - genetics Embryo cells Embryo, Mammalian Embryo, Nonmammalian Embryogenesis Embryonic Development - genetics Embryonic growth stage Embryos Exon skipping Exons Humanities and Social Sciences Kinases Lethality Mice Mouse Embryonic Stem Cells - cytology Mouse Embryonic Stem Cells - metabolism multidisciplinary Nervous system Neural Plate - cytology Neural tube Neuroectoderm Organogenesis Organogenesis - genetics Protein Binding Protein-serine/threonine kinase Proteins Receptors Ribonucleic acid Ribonucleoprotein, U2 Small Nuclear - metabolism Ribonucleoproteins (small nuclear) Ribonucleoproteins (U2 small nuclear) RNA RNA, Messenger - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Science Science (multidisciplinary) Spliceosomes - metabolism Splicing Stem cell transplantation Stem cells Tumorigenicity Xenopus laevis
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