Gamma heavy chain disease associated with aggressive B lymphoma in the context of myelodysplastic syndrome

Heavy chain disease is a rare entity characterized by the production of incomplete immunoglobulin heavy chain without associated light chain. It is a B-cell lymphoproliferation, categorized according to the immunoglobulin involved. It is often associated with lymphomas but also with autoimmune disea...

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Veröffentlicht in:La revue de medecine interne 2021-05, Vol.42 (5), p.355-358
Hauptverfasser: Nivet, C, Deluche, L, Carreiro, M
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Deluche, L
Carreiro, M
description Heavy chain disease is a rare entity characterized by the production of incomplete immunoglobulin heavy chain without associated light chain. It is a B-cell lymphoproliferation, categorized according to the immunoglobulin involved. It is often associated with lymphomas but also with autoimmune diseases. We report the case of a 70-year-old patient who presented a gamma-type heavy chain disease, associated with a diffuse large B-cell lymphoma in the context of myelodysplastic syndrome. This is the first case of diffuse large B-cell lymphoma associated gamma heavy chain disease described in the context of myelodysplastic syndrome.
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title Gamma heavy chain disease associated with aggressive B lymphoma in the context of myelodysplastic syndrome
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