Novel bisthiolane polysulfides from lachrymatory factor synthase-suppressed onion and their in vitro cyclooxygenase-1 inhibitory activity

•New bisthiolane polysulfides were isolated from a reaction model of tearless onion.•The three compounds were confirmed in authentic tearless onion juice.•The isolated two compounds inhibited COX-1 activity more effectively than aspirin.•Lyophilized forms of the compounds could be stored stably for...

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Veröffentlicht in:	Food chemistry 2021-05, Vol.344, p.128636-128636, Article 128636
Hauptverfasser:	Aoyagi, Morihiro, Imai, Shinsuke, Kamoi, Takahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Allium cepa Cepathiolane COX-1 inhibition Cyclooxygenase Inhibitors - chemistry Cyclooxygenase Inhibitors - pharmacology Drug Evaluation, Preclinical Intramolecular Oxidoreductases - chemistry Molecular Structure Onions - chemistry Polysulfide Sulfides - chemistry Sulfides - pharmacology Tearless onion Thiolane Thiolanosulfide
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