Relationships of physical and breast cancer phenotypes with three single-nucleotide polymorphisms (rs2046210, rs3757318, and rs3803662) associated with breast cancer risk in Japanese women
Background Recent genome-wide association studies have shown that many single-nucleotide polymorphisms (SNPs) are associated with breast cancer risk. However, it is often unclear how these SNPs are related to breast cancer. Analysis of associations between SNPs and phenotypes may be important for de...
Gespeichert in:
| Veröffentlicht in: | Breast cancer (Tokyo, Japan) Japan), 2021-03, Vol.28 (2), p.478-487 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 487 |
|---|---|
| container_issue | 2 |
| container_start_page | 478 |
| container_title | Breast cancer (Tokyo, Japan) |
| container_volume | 28 |
| creator | Kawada, Kengo Taira, Naruto Mizoo, Taeko Suzuki, Yoko Kajiwara, Yukiko Hatono, Minami Tsukioki, Takahiro Kochi, Mariko Abe, Yuko Nishiyama, Keiko Iwamoto, Takayuki Ikeda, Hirokuni Shien, Tadahiko Doihara, Hiroyoshi Ishihara, Setsuko Kawai, Hiroshi Kawasaki, Kensuke Ishibe, Yoichi Ogasawara, Yutaka Toyooka, Shinichi |
| description | Background
Recent genome-wide association studies have shown that many single-nucleotide polymorphisms (SNPs) are associated with breast cancer risk. However, it is often unclear how these SNPs are related to breast cancer. Analysis of associations between SNPs and phenotypes may be important for determining mechanisms of action, including carcinogenesis.
Methods
In previous case–control studies, we found three SNPs (rs2046210, rs3757318, and rs3573318) associated with breast cancer risk in Japanese women. Among these SNPs, two (rs2046210 and rs3757318) are located at 6q25.1, in proximity to the
estrogen receptor 1 gene
(
ESR1
). Using data from these studies, we examined associations between factors related to breast cancer risk, such as height, weight, and breast density, and the three SNPs in cases and controls. We also investigated whether the SNPs correlated with breast cancer features, such as estrogen receptor (ER), progesterone receptor (PgR), and human epidermal growth factor receptor type-2 (HER2) status, and clinical stage.
Results
There was a significant difference in mean height between risk and non-risk allele carriers for rs2046210 (156.0 ± 5.8 vs. 154.3 ± 5.5 cm,
p
= 0.002), and rs3757318 (155.8 ± 5.7 vs. 154.7 ± 5.6 cm,
p
= 0.035) in cases, but no significant associations between height and these SNPs in controls. There was also a significant difference in breast density between risk and non-risk allele carriers for rs2046210 (
p
= 0.040) and rs3757318 (
p
= 0.044) in cases. rs2046210 and rs3757318 risk allele carriers tended to have higher breast density in all subjects and in controls. In cases, rs3757318 risk allele carriers were also significantly more likely to be ER-negative compared to non-risk allele carriers (ER-positive rate: 77% vs. 84%,
p
= 0.036).
Conclusions
SNPs rs2046210 and rs3757318, which are associated with breast cancer risk in Japanese women, were significantly associated with height and high breast density, and this association was particularly strong in those with breast cancer. These findings suggest that SNPs in the
ESR1
gene region affect phenotypes such as height and breast density. |
| doi_str_mv | 10.1007/s12282-020-01185-x |
| format | Article |
| fullrecord | <record><control><sourceid>gale_cross</sourceid><recordid>TN_cdi_pubmed_primary_33185851</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A712280318</galeid><sourcerecordid>A712280318</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-c94b141aa129bf5c3aa0dc609855b2ee42108f09b4bb3e06b937180213bca2e23</originalsourceid><addsrcrecordid>eNp9kdtqFTEUhgdRbK2-gBcS8KZCp64kc8hcluKRgiB6HZLMmj2pM8mQNZt2v5sPZ9pRoSCSixzW__8ryVcULzmcc4D2LXEhlChBQAmcq7q8fVQcc6WgrISUj_NaVlA2qlFHxTOia4BKttA8LY6kzHJV8-Pi51eczOpjoNEvxOLAlvFA3pmJmdAzm9DQypwJDlMuYYjrYUFiN34d2TomREY-7CYsw95NGFffI1vidJhjWkZPM7HTRAKqRnA4Y4lkW7e5-9l9fN4qkE0j3jBDFJ03K_Zb9sPOydMP5gP7bBYTkJDdxBnD8-LJYCbCF7_nk-L7-3ffLj-WV18-fLq8uCpdJdVauq6yvOLGcNHZoXbSGOhdA52qaysQq3w1NUBnK2slQmM72XIFgkvrjEAhT4rXW-7OTKh9GOKajJs9OX3R3kGA_KKsOv-HKo8eZ-9iwMHn8wcGsRlcikQJB70kP5t00Bz0HWG9EdaZsL4nrG-z6dVmWvZ2xv6v5Q_SLJCbgHIp7DDp67hPIf_P_2J_AQfwsW8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Relationships of physical and breast cancer phenotypes with three single-nucleotide polymorphisms (rs2046210, rs3757318, and rs3803662) associated with breast cancer risk in Japanese women</title><source>SpringerLink Journals - AutoHoldings</source><creator>Kawada, Kengo ; Taira, Naruto ; Mizoo, Taeko ; Suzuki, Yoko ; Kajiwara, Yukiko ; Hatono, Minami ; Tsukioki, Takahiro ; Kochi, Mariko ; Abe, Yuko ; Nishiyama, Keiko ; Iwamoto, Takayuki ; Ikeda, Hirokuni ; Shien, Tadahiko ; Doihara, Hiroyoshi ; Ishihara, Setsuko ; Kawai, Hiroshi ; Kawasaki, Kensuke ; Ishibe, Yoichi ; Ogasawara, Yutaka ; Toyooka, Shinichi</creator><creatorcontrib>Kawada, Kengo ; Taira, Naruto ; Mizoo, Taeko ; Suzuki, Yoko ; Kajiwara, Yukiko ; Hatono, Minami ; Tsukioki, Takahiro ; Kochi, Mariko ; Abe, Yuko ; Nishiyama, Keiko ; Iwamoto, Takayuki ; Ikeda, Hirokuni ; Shien, Tadahiko ; Doihara, Hiroyoshi ; Ishihara, Setsuko ; Kawai, Hiroshi ; Kawasaki, Kensuke ; Ishibe, Yoichi ; Ogasawara, Yutaka ; Toyooka, Shinichi</creatorcontrib><description>Background
Recent genome-wide association studies have shown that many single-nucleotide polymorphisms (SNPs) are associated with breast cancer risk. However, it is often unclear how these SNPs are related to breast cancer. Analysis of associations between SNPs and phenotypes may be important for determining mechanisms of action, including carcinogenesis.
Methods
In previous case–control studies, we found three SNPs (rs2046210, rs3757318, and rs3573318) associated with breast cancer risk in Japanese women. Among these SNPs, two (rs2046210 and rs3757318) are located at 6q25.1, in proximity to the
estrogen receptor 1 gene
(
ESR1
). Using data from these studies, we examined associations between factors related to breast cancer risk, such as height, weight, and breast density, and the three SNPs in cases and controls. We also investigated whether the SNPs correlated with breast cancer features, such as estrogen receptor (ER), progesterone receptor (PgR), and human epidermal growth factor receptor type-2 (HER2) status, and clinical stage.
Results
There was a significant difference in mean height between risk and non-risk allele carriers for rs2046210 (156.0 ± 5.8 vs. 154.3 ± 5.5 cm,
p
= 0.002), and rs3757318 (155.8 ± 5.7 vs. 154.7 ± 5.6 cm,
p
= 0.035) in cases, but no significant associations between height and these SNPs in controls. There was also a significant difference in breast density between risk and non-risk allele carriers for rs2046210 (
p
= 0.040) and rs3757318 (
p
= 0.044) in cases. rs2046210 and rs3757318 risk allele carriers tended to have higher breast density in all subjects and in controls. In cases, rs3757318 risk allele carriers were also significantly more likely to be ER-negative compared to non-risk allele carriers (ER-positive rate: 77% vs. 84%,
p
= 0.036).
Conclusions
SNPs rs2046210 and rs3757318, which are associated with breast cancer risk in Japanese women, were significantly associated with height and high breast density, and this association was particularly strong in those with breast cancer. These findings suggest that SNPs in the
ESR1
gene region affect phenotypes such as height and breast density.</description><identifier>ISSN: 1340-6868</identifier><identifier>EISSN: 1880-4233</identifier><identifier>DOI: 10.1007/s12282-020-01185-x</identifier><identifier>PMID: 33185851</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Breast cancer ; Cancer ; Cancer Research ; Epidermal growth factor ; Estrogen ; Genetic aspects ; Genomes ; Genomics ; Health aspects ; Medicine ; Medicine & Public Health ; Oncology ; Oncology, Experimental ; Original Article ; Phenotype ; Progesterone ; Risk factors ; Single nucleotide polymorphisms ; Surgery ; Surgical Oncology ; Women</subject><ispartof>Breast cancer (Tokyo, Japan), 2021-03, Vol.28 (2), p.478-487</ispartof><rights>The Japanese Breast Cancer Society 2020</rights><rights>COPYRIGHT 2021 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-c94b141aa129bf5c3aa0dc609855b2ee42108f09b4bb3e06b937180213bca2e23</citedby><cites>FETCH-LOGICAL-c438t-c94b141aa129bf5c3aa0dc609855b2ee42108f09b4bb3e06b937180213bca2e23</cites><orcidid>0000-0003-4266-1117</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12282-020-01185-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12282-020-01185-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33185851$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawada, Kengo</creatorcontrib><creatorcontrib>Taira, Naruto</creatorcontrib><creatorcontrib>Mizoo, Taeko</creatorcontrib><creatorcontrib>Suzuki, Yoko</creatorcontrib><creatorcontrib>Kajiwara, Yukiko</creatorcontrib><creatorcontrib>Hatono, Minami</creatorcontrib><creatorcontrib>Tsukioki, Takahiro</creatorcontrib><creatorcontrib>Kochi, Mariko</creatorcontrib><creatorcontrib>Abe, Yuko</creatorcontrib><creatorcontrib>Nishiyama, Keiko</creatorcontrib><creatorcontrib>Iwamoto, Takayuki</creatorcontrib><creatorcontrib>Ikeda, Hirokuni</creatorcontrib><creatorcontrib>Shien, Tadahiko</creatorcontrib><creatorcontrib>Doihara, Hiroyoshi</creatorcontrib><creatorcontrib>Ishihara, Setsuko</creatorcontrib><creatorcontrib>Kawai, Hiroshi</creatorcontrib><creatorcontrib>Kawasaki, Kensuke</creatorcontrib><creatorcontrib>Ishibe, Yoichi</creatorcontrib><creatorcontrib>Ogasawara, Yutaka</creatorcontrib><creatorcontrib>Toyooka, Shinichi</creatorcontrib><title>Relationships of physical and breast cancer phenotypes with three single-nucleotide polymorphisms (rs2046210, rs3757318, and rs3803662) associated with breast cancer risk in Japanese women</title><title>Breast cancer (Tokyo, Japan)</title><addtitle>Breast Cancer</addtitle><addtitle>Breast Cancer</addtitle><description>Background
Recent genome-wide association studies have shown that many single-nucleotide polymorphisms (SNPs) are associated with breast cancer risk. However, it is often unclear how these SNPs are related to breast cancer. Analysis of associations between SNPs and phenotypes may be important for determining mechanisms of action, including carcinogenesis.
Methods
In previous case–control studies, we found three SNPs (rs2046210, rs3757318, and rs3573318) associated with breast cancer risk in Japanese women. Among these SNPs, two (rs2046210 and rs3757318) are located at 6q25.1, in proximity to the
estrogen receptor 1 gene
(
ESR1
). Using data from these studies, we examined associations between factors related to breast cancer risk, such as height, weight, and breast density, and the three SNPs in cases and controls. We also investigated whether the SNPs correlated with breast cancer features, such as estrogen receptor (ER), progesterone receptor (PgR), and human epidermal growth factor receptor type-2 (HER2) status, and clinical stage.
Results
There was a significant difference in mean height between risk and non-risk allele carriers for rs2046210 (156.0 ± 5.8 vs. 154.3 ± 5.5 cm,
p
= 0.002), and rs3757318 (155.8 ± 5.7 vs. 154.7 ± 5.6 cm,
p
= 0.035) in cases, but no significant associations between height and these SNPs in controls. There was also a significant difference in breast density between risk and non-risk allele carriers for rs2046210 (
p
= 0.040) and rs3757318 (
p
= 0.044) in cases. rs2046210 and rs3757318 risk allele carriers tended to have higher breast density in all subjects and in controls. In cases, rs3757318 risk allele carriers were also significantly more likely to be ER-negative compared to non-risk allele carriers (ER-positive rate: 77% vs. 84%,
p
= 0.036).
Conclusions
SNPs rs2046210 and rs3757318, which are associated with breast cancer risk in Japanese women, were significantly associated with height and high breast density, and this association was particularly strong in those with breast cancer. These findings suggest that SNPs in the
ESR1
gene region affect phenotypes such as height and breast density.</description><subject>Breast cancer</subject><subject>Cancer</subject><subject>Cancer Research</subject><subject>Epidermal growth factor</subject><subject>Estrogen</subject><subject>Genetic aspects</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Health aspects</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Oncology, Experimental</subject><subject>Original Article</subject><subject>Phenotype</subject><subject>Progesterone</subject><subject>Risk factors</subject><subject>Single nucleotide polymorphisms</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Women</subject><issn>1340-6868</issn><issn>1880-4233</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kdtqFTEUhgdRbK2-gBcS8KZCp64kc8hcluKRgiB6HZLMmj2pM8mQNZt2v5sPZ9pRoSCSixzW__8ryVcULzmcc4D2LXEhlChBQAmcq7q8fVQcc6WgrISUj_NaVlA2qlFHxTOia4BKttA8LY6kzHJV8-Pi51eczOpjoNEvxOLAlvFA3pmJmdAzm9DQypwJDlMuYYjrYUFiN34d2TomREY-7CYsw95NGFffI1vidJhjWkZPM7HTRAKqRnA4Y4lkW7e5-9l9fN4qkE0j3jBDFJ03K_Zb9sPOydMP5gP7bBYTkJDdxBnD8-LJYCbCF7_nk-L7-3ffLj-WV18-fLq8uCpdJdVauq6yvOLGcNHZoXbSGOhdA52qaysQq3w1NUBnK2slQmM72XIFgkvrjEAhT4rXW-7OTKh9GOKajJs9OX3R3kGA_KKsOv-HKo8eZ-9iwMHn8wcGsRlcikQJB70kP5t00Bz0HWG9EdaZsL4nrG-z6dVmWvZ2xv6v5Q_SLJCbgHIp7DDp67hPIf_P_2J_AQfwsW8</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Kawada, Kengo</creator><creator>Taira, Naruto</creator><creator>Mizoo, Taeko</creator><creator>Suzuki, Yoko</creator><creator>Kajiwara, Yukiko</creator><creator>Hatono, Minami</creator><creator>Tsukioki, Takahiro</creator><creator>Kochi, Mariko</creator><creator>Abe, Yuko</creator><creator>Nishiyama, Keiko</creator><creator>Iwamoto, Takayuki</creator><creator>Ikeda, Hirokuni</creator><creator>Shien, Tadahiko</creator><creator>Doihara, Hiroyoshi</creator><creator>Ishihara, Setsuko</creator><creator>Kawai, Hiroshi</creator><creator>Kawasaki, Kensuke</creator><creator>Ishibe, Yoichi</creator><creator>Ogasawara, Yutaka</creator><creator>Toyooka, Shinichi</creator><general>Springer Singapore</general><general>Springer</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0003-4266-1117</orcidid></search><sort><creationdate>20210301</creationdate><title>Relationships of physical and breast cancer phenotypes with three single-nucleotide polymorphisms (rs2046210, rs3757318, and rs3803662) associated with breast cancer risk in Japanese women</title><author>Kawada, Kengo ; Taira, Naruto ; Mizoo, Taeko ; Suzuki, Yoko ; Kajiwara, Yukiko ; Hatono, Minami ; Tsukioki, Takahiro ; Kochi, Mariko ; Abe, Yuko ; Nishiyama, Keiko ; Iwamoto, Takayuki ; Ikeda, Hirokuni ; Shien, Tadahiko ; Doihara, Hiroyoshi ; Ishihara, Setsuko ; Kawai, Hiroshi ; Kawasaki, Kensuke ; Ishibe, Yoichi ; Ogasawara, Yutaka ; Toyooka, Shinichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-c94b141aa129bf5c3aa0dc609855b2ee42108f09b4bb3e06b937180213bca2e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Breast cancer</topic><topic>Cancer</topic><topic>Cancer Research</topic><topic>Epidermal growth factor</topic><topic>Estrogen</topic><topic>Genetic aspects</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Health aspects</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Oncology, Experimental</topic><topic>Original Article</topic><topic>Phenotype</topic><topic>Progesterone</topic><topic>Risk factors</topic><topic>Single nucleotide polymorphisms</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawada, Kengo</creatorcontrib><creatorcontrib>Taira, Naruto</creatorcontrib><creatorcontrib>Mizoo, Taeko</creatorcontrib><creatorcontrib>Suzuki, Yoko</creatorcontrib><creatorcontrib>Kajiwara, Yukiko</creatorcontrib><creatorcontrib>Hatono, Minami</creatorcontrib><creatorcontrib>Tsukioki, Takahiro</creatorcontrib><creatorcontrib>Kochi, Mariko</creatorcontrib><creatorcontrib>Abe, Yuko</creatorcontrib><creatorcontrib>Nishiyama, Keiko</creatorcontrib><creatorcontrib>Iwamoto, Takayuki</creatorcontrib><creatorcontrib>Ikeda, Hirokuni</creatorcontrib><creatorcontrib>Shien, Tadahiko</creatorcontrib><creatorcontrib>Doihara, Hiroyoshi</creatorcontrib><creatorcontrib>Ishihara, Setsuko</creatorcontrib><creatorcontrib>Kawai, Hiroshi</creatorcontrib><creatorcontrib>Kawasaki, Kensuke</creatorcontrib><creatorcontrib>Ishibe, Yoichi</creatorcontrib><creatorcontrib>Ogasawara, Yutaka</creatorcontrib><creatorcontrib>Toyooka, Shinichi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Breast cancer (Tokyo, Japan)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawada, Kengo</au><au>Taira, Naruto</au><au>Mizoo, Taeko</au><au>Suzuki, Yoko</au><au>Kajiwara, Yukiko</au><au>Hatono, Minami</au><au>Tsukioki, Takahiro</au><au>Kochi, Mariko</au><au>Abe, Yuko</au><au>Nishiyama, Keiko</au><au>Iwamoto, Takayuki</au><au>Ikeda, Hirokuni</au><au>Shien, Tadahiko</au><au>Doihara, Hiroyoshi</au><au>Ishihara, Setsuko</au><au>Kawai, Hiroshi</au><au>Kawasaki, Kensuke</au><au>Ishibe, Yoichi</au><au>Ogasawara, Yutaka</au><au>Toyooka, Shinichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationships of physical and breast cancer phenotypes with three single-nucleotide polymorphisms (rs2046210, rs3757318, and rs3803662) associated with breast cancer risk in Japanese women</atitle><jtitle>Breast cancer (Tokyo, Japan)</jtitle><stitle>Breast Cancer</stitle><addtitle>Breast Cancer</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>28</volume><issue>2</issue><spage>478</spage><epage>487</epage><pages>478-487</pages><issn>1340-6868</issn><eissn>1880-4233</eissn><abstract>Background
Recent genome-wide association studies have shown that many single-nucleotide polymorphisms (SNPs) are associated with breast cancer risk. However, it is often unclear how these SNPs are related to breast cancer. Analysis of associations between SNPs and phenotypes may be important for determining mechanisms of action, including carcinogenesis.
Methods
In previous case–control studies, we found three SNPs (rs2046210, rs3757318, and rs3573318) associated with breast cancer risk in Japanese women. Among these SNPs, two (rs2046210 and rs3757318) are located at 6q25.1, in proximity to the
estrogen receptor 1 gene
(
ESR1
). Using data from these studies, we examined associations between factors related to breast cancer risk, such as height, weight, and breast density, and the three SNPs in cases and controls. We also investigated whether the SNPs correlated with breast cancer features, such as estrogen receptor (ER), progesterone receptor (PgR), and human epidermal growth factor receptor type-2 (HER2) status, and clinical stage.
Results
There was a significant difference in mean height between risk and non-risk allele carriers for rs2046210 (156.0 ± 5.8 vs. 154.3 ± 5.5 cm,
p
= 0.002), and rs3757318 (155.8 ± 5.7 vs. 154.7 ± 5.6 cm,
p
= 0.035) in cases, but no significant associations between height and these SNPs in controls. There was also a significant difference in breast density between risk and non-risk allele carriers for rs2046210 (
p
= 0.040) and rs3757318 (
p
= 0.044) in cases. rs2046210 and rs3757318 risk allele carriers tended to have higher breast density in all subjects and in controls. In cases, rs3757318 risk allele carriers were also significantly more likely to be ER-negative compared to non-risk allele carriers (ER-positive rate: 77% vs. 84%,
p
= 0.036).
Conclusions
SNPs rs2046210 and rs3757318, which are associated with breast cancer risk in Japanese women, were significantly associated with height and high breast density, and this association was particularly strong in those with breast cancer. These findings suggest that SNPs in the
ESR1
gene region affect phenotypes such as height and breast density.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>33185851</pmid><doi>10.1007/s12282-020-01185-x</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-4266-1117</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1340-6868 |
| ispartof | Breast cancer (Tokyo, Japan), 2021-03, Vol.28 (2), p.478-487 |
| issn | 1340-6868 1880-4233 |
| language | eng |
| recordid | cdi_pubmed_primary_33185851 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Breast cancer Cancer Cancer Research Epidermal growth factor Estrogen Genetic aspects Genomes Genomics Health aspects Medicine Medicine & Public Health Oncology Oncology, Experimental Original Article Phenotype Progesterone Risk factors Single nucleotide polymorphisms Surgery Surgical Oncology Women |
| title | Relationships of physical and breast cancer phenotypes with three single-nucleotide polymorphisms (rs2046210, rs3757318, and rs3803662) associated with breast cancer risk in Japanese women |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T09%3A49%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Relationships%20of%20physical%20and%20breast%20cancer%20phenotypes%20with%20three%20single-nucleotide%20polymorphisms%20(rs2046210,%20rs3757318,%20and%20rs3803662)%20associated%20with%20breast%20cancer%20risk%20in%20Japanese%20women&rft.jtitle=Breast%20cancer%20(Tokyo,%20Japan)&rft.au=Kawada,%20Kengo&rft.date=2021-03-01&rft.volume=28&rft.issue=2&rft.spage=478&rft.epage=487&rft.pages=478-487&rft.issn=1340-6868&rft.eissn=1880-4233&rft_id=info:doi/10.1007/s12282-020-01185-x&rft_dat=%3Cgale_cross%3EA712280318%3C/gale_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/33185851&rft_galeid=A712280318&rfr_iscdi=true |