Glucose-rich polysaccharide from dried 'Shixia' longan activates macrophages through Ca 2+ and CR3- mediated MAPKs and PI3K-AKT pathways

A water-soluble glucose-rich polysaccharide from dried 'Shixia' longan pulp (LPsx) has been isolated for the first time, and its structure and immuno-regulatory mechanism were studied. LPsx is a hetero-polysaccharide with the average molecular weight 4102 g/mol. It was mainly consisted of...

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Veröffentlicht in:	International journal of biological macromolecules 2021-01, Vol.167, p.845
Hauptverfasser:	Lan, Haibo, Cheng, Yongxia, Mu, Jingjing, Huang, Yanfen, Chen, Huifang, Zhao, Lei, Wang, Kai, Hu, Zhuoyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Cytokines - biosynthesis Gene Expression Glucose - chemistry Macrophage-1 Antigen - metabolism Macrophages - drug effects Macrophages - physiology Magnetic Resonance Spectroscopy Medicine, Chinese Traditional Mice Mitogen-Activated Protein Kinases - metabolism Models, Biological Molecular Weight Monosaccharides - chemistry Phagocytosis Phosphatidylinositol 3-Kinases - metabolism Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Polysaccharides - chemistry Polysaccharides - isolation & purification Proto-Oncogene Proteins c-akt - metabolism RAW 264.7 Cells Receptors, Cell Surface - metabolism Sapindaceae - chemistry
Online-Zugang:	Volltext
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