A review of T helper 17 cell-related cytokines in serum and saliva in periodontitis
•Cytokines play a key role in periodontitis.•Their exact mechanism of actions still needs to be delineated.•IL-17F, IL-21, IL-25, IL-31 and IL-33 require further investigation.•More research especially in in vivo cytokine networks are required. Periodontitis is a chronic inflammatory disease with a...
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| Veröffentlicht in: | Cytokine (Philadelphia, Pa.) Pa.), 2021-02, Vol.138, p.155340-155340, Article 155340 |
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| container_title | Cytokine (Philadelphia, Pa.) |
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| creator | Medara, Nidhi Lenzo, Jason C. Walsh, Katrina A. Reynolds, Eric C. Darby, Ivan B. O'Brien-Simpson, Neil M. |
| description | •Cytokines play a key role in periodontitis.•Their exact mechanism of actions still needs to be delineated.•IL-17F, IL-21, IL-25, IL-31 and IL-33 require further investigation.•More research especially in in vivo cytokine networks are required.
Periodontitis is a chronic inflammatory disease with a complex underlying immunopathology. Cytokines, as molecular mediators of inflammation, play a role in all stages of disease progression. T helper 17 (Th17) cells are thought to play a role in periodontitis. Th17 cell development and maintenance requires a pro-inflammatory cytokine milieu, with many of the cytokines implicated in the pathogenesis of periodontitis. Serum and saliva are easily accessible biofluids which can represent the systemic and local environment to promote the development of Th17 cells. Here we review human clinical studies that investigate IL-1β, IL-4, IL-6, IL-10, IL-17A, IL-17F, IL-21, IL-22, IL-23, IL-25, IL-31, IL-33, IFN-γ, sCD40L and TNF-α in serum and saliva in periodontitis. We highlight their putative role in the pathogenesis of periodontitis and place them within a wider context of animal and other clinical studies. |
| doi_str_mv | 10.1016/j.cyto.2020.155340 |
| format | Article |
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Periodontitis is a chronic inflammatory disease with a complex underlying immunopathology. Cytokines, as molecular mediators of inflammation, play a role in all stages of disease progression. T helper 17 (Th17) cells are thought to play a role in periodontitis. Th17 cell development and maintenance requires a pro-inflammatory cytokine milieu, with many of the cytokines implicated in the pathogenesis of periodontitis. Serum and saliva are easily accessible biofluids which can represent the systemic and local environment to promote the development of Th17 cells. Here we review human clinical studies that investigate IL-1β, IL-4, IL-6, IL-10, IL-17A, IL-17F, IL-21, IL-22, IL-23, IL-25, IL-31, IL-33, IFN-γ, sCD40L and TNF-α in serum and saliva in periodontitis. We highlight their putative role in the pathogenesis of periodontitis and place them within a wider context of animal and other clinical studies.</description><identifier>ISSN: 1043-4666</identifier><identifier>EISSN: 1096-0023</identifier><identifier>DOI: 10.1016/j.cyto.2020.155340</identifier><identifier>PMID: 33144024</identifier><language>eng</language><publisher>LONDON: Elsevier Ltd</publisher><subject>Animals ; Biochemistry & Molecular Biology ; Cell Biology ; Cross-Sectional Studies ; Cytokines ; Cytokines - metabolism ; Humans ; Immunology ; Inflammation - metabolism ; Interleukin-17 - biosynthesis ; Interleukin-33 - biosynthesis ; Interleukins - biosynthesis ; Life Sciences & Biomedicine ; Longitudinal Studies ; Mice ; Periodontitis ; Periodontitis - blood ; Periodontitis - metabolism ; Saliva ; Saliva - metabolism ; Science & Technology ; Serum ; T helper 17 cells ; Th17 Cells - metabolism</subject><ispartof>Cytokine (Philadelphia, Pa.), 2021-02, Vol.138, p.155340-155340, Article 155340</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>14</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000612690000015</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c356t-dd3ee407dc8a5beedf66dd23b1444e59cefeaf7b7f77f1270a1d78036bde4bb03</citedby><cites>FETCH-LOGICAL-c356t-dd3ee407dc8a5beedf66dd23b1444e59cefeaf7b7f77f1270a1d78036bde4bb03</cites><orcidid>0000-0002-6457-5327 ; 0000-0002-5450-0647 ; 0000-0002-6618-4856 ; 0000-0001-8462-5603 ; 0000-0002-0564-9250</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cyto.2020.155340$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3554,27933,27934,39267,46004</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33144024$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Medara, Nidhi</creatorcontrib><creatorcontrib>Lenzo, Jason C.</creatorcontrib><creatorcontrib>Walsh, Katrina A.</creatorcontrib><creatorcontrib>Reynolds, Eric C.</creatorcontrib><creatorcontrib>Darby, Ivan B.</creatorcontrib><creatorcontrib>O'Brien-Simpson, Neil M.</creatorcontrib><title>A review of T helper 17 cell-related cytokines in serum and saliva in periodontitis</title><title>Cytokine (Philadelphia, Pa.)</title><addtitle>CYTOKINE</addtitle><addtitle>Cytokine</addtitle><description>•Cytokines play a key role in periodontitis.•Their exact mechanism of actions still needs to be delineated.•IL-17F, IL-21, IL-25, IL-31 and IL-33 require further investigation.•More research especially in in vivo cytokine networks are required.
Periodontitis is a chronic inflammatory disease with a complex underlying immunopathology. Cytokines, as molecular mediators of inflammation, play a role in all stages of disease progression. T helper 17 (Th17) cells are thought to play a role in periodontitis. Th17 cell development and maintenance requires a pro-inflammatory cytokine milieu, with many of the cytokines implicated in the pathogenesis of periodontitis. Serum and saliva are easily accessible biofluids which can represent the systemic and local environment to promote the development of Th17 cells. Here we review human clinical studies that investigate IL-1β, IL-4, IL-6, IL-10, IL-17A, IL-17F, IL-21, IL-22, IL-23, IL-25, IL-31, IL-33, IFN-γ, sCD40L and TNF-α in serum and saliva in periodontitis. We highlight their putative role in the pathogenesis of periodontitis and place them within a wider context of animal and other clinical studies.</description><subject>Animals</subject><subject>Biochemistry & Molecular Biology</subject><subject>Cell Biology</subject><subject>Cross-Sectional Studies</subject><subject>Cytokines</subject><subject>Cytokines - metabolism</subject><subject>Humans</subject><subject>Immunology</subject><subject>Inflammation - metabolism</subject><subject>Interleukin-17 - biosynthesis</subject><subject>Interleukin-33 - biosynthesis</subject><subject>Interleukins - biosynthesis</subject><subject>Life Sciences & Biomedicine</subject><subject>Longitudinal Studies</subject><subject>Mice</subject><subject>Periodontitis</subject><subject>Periodontitis - blood</subject><subject>Periodontitis - metabolism</subject><subject>Saliva</subject><subject>Saliva - metabolism</subject><subject>Science & Technology</subject><subject>Serum</subject><subject>T helper 17 cells</subject><subject>Th17 Cells - metabolism</subject><issn>1043-4666</issn><issn>1096-0023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><recordid>eNqNkU9LHDEYh0OxVGv7BTxIjoLMmn-T7EAvsqgtCB5qzyGTvMFsZydrklH89s0wW4-luSS8PE_yvr8gdEbJihIqr7Yr-1biihFWC23LBfmATijpZEMI40fzWfBGSCmP0eect4SQjiv1CR1zToUgTJygn9c4wUuAVxw9fsRPMOwhYaqwhWFoEgymgMPzO7_DCBmHEWdI0w6b0eFshvBi5lqVQnRxLKGE_AV99GbI8PWwn6JftzePm-_N_cPdj831fWN5K0vjHAcQRDm7Nm0P4LyUzjHe194EtJ0FD8arXnmlPGWKGOrUmnDZOxB9T_gpulju3af4PEEuehfy3LcZIU5ZM9Eq2VHa0oqyBbUp5pzA630KO5PeNCV6DlNv9TyknsPUS5hVOj_cP_U7cO_K3_QqsF6AV-ijzzbAaOEdq3FLymRH5kXbTSimhDhu4jSWql7-v1rpbwsNNc76W0kfDBcS2KJdDP8a5A_y96az</recordid><startdate>202102</startdate><enddate>202102</enddate><creator>Medara, Nidhi</creator><creator>Lenzo, Jason C.</creator><creator>Walsh, Katrina A.</creator><creator>Reynolds, Eric C.</creator><creator>Darby, Ivan B.</creator><creator>O'Brien-Simpson, Neil M.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6457-5327</orcidid><orcidid>https://orcid.org/0000-0002-5450-0647</orcidid><orcidid>https://orcid.org/0000-0002-6618-4856</orcidid><orcidid>https://orcid.org/0000-0001-8462-5603</orcidid><orcidid>https://orcid.org/0000-0002-0564-9250</orcidid></search><sort><creationdate>202102</creationdate><title>A review of T helper 17 cell-related cytokines in serum and saliva in periodontitis</title><author>Medara, Nidhi ; Lenzo, Jason C. ; Walsh, Katrina A. ; Reynolds, Eric C. ; Darby, Ivan B. ; O'Brien-Simpson, Neil M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-dd3ee407dc8a5beedf66dd23b1444e59cefeaf7b7f77f1270a1d78036bde4bb03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Biochemistry & Molecular Biology</topic><topic>Cell Biology</topic><topic>Cross-Sectional Studies</topic><topic>Cytokines</topic><topic>Cytokines - metabolism</topic><topic>Humans</topic><topic>Immunology</topic><topic>Inflammation - metabolism</topic><topic>Interleukin-17 - biosynthesis</topic><topic>Interleukin-33 - biosynthesis</topic><topic>Interleukins - biosynthesis</topic><topic>Life Sciences & Biomedicine</topic><topic>Longitudinal Studies</topic><topic>Mice</topic><topic>Periodontitis</topic><topic>Periodontitis - blood</topic><topic>Periodontitis - metabolism</topic><topic>Saliva</topic><topic>Saliva - metabolism</topic><topic>Science & Technology</topic><topic>Serum</topic><topic>T helper 17 cells</topic><topic>Th17 Cells - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Medara, Nidhi</creatorcontrib><creatorcontrib>Lenzo, Jason C.</creatorcontrib><creatorcontrib>Walsh, Katrina A.</creatorcontrib><creatorcontrib>Reynolds, Eric C.</creatorcontrib><creatorcontrib>Darby, Ivan B.</creatorcontrib><creatorcontrib>O'Brien-Simpson, Neil M.</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cytokine (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Medara, Nidhi</au><au>Lenzo, Jason C.</au><au>Walsh, Katrina A.</au><au>Reynolds, Eric C.</au><au>Darby, Ivan B.</au><au>O'Brien-Simpson, Neil M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A review of T helper 17 cell-related cytokines in serum and saliva in periodontitis</atitle><jtitle>Cytokine (Philadelphia, Pa.)</jtitle><stitle>CYTOKINE</stitle><addtitle>Cytokine</addtitle><date>2021-02</date><risdate>2021</risdate><volume>138</volume><spage>155340</spage><epage>155340</epage><pages>155340-155340</pages><artnum>155340</artnum><issn>1043-4666</issn><eissn>1096-0023</eissn><abstract>•Cytokines play a key role in periodontitis.•Their exact mechanism of actions still needs to be delineated.•IL-17F, IL-21, IL-25, IL-31 and IL-33 require further investigation.•More research especially in in vivo cytokine networks are required.
Periodontitis is a chronic inflammatory disease with a complex underlying immunopathology. Cytokines, as molecular mediators of inflammation, play a role in all stages of disease progression. T helper 17 (Th17) cells are thought to play a role in periodontitis. Th17 cell development and maintenance requires a pro-inflammatory cytokine milieu, with many of the cytokines implicated in the pathogenesis of periodontitis. Serum and saliva are easily accessible biofluids which can represent the systemic and local environment to promote the development of Th17 cells. Here we review human clinical studies that investigate IL-1β, IL-4, IL-6, IL-10, IL-17A, IL-17F, IL-21, IL-22, IL-23, IL-25, IL-31, IL-33, IFN-γ, sCD40L and TNF-α in serum and saliva in periodontitis. We highlight their putative role in the pathogenesis of periodontitis and place them within a wider context of animal and other clinical studies.</abstract><cop>LONDON</cop><pub>Elsevier Ltd</pub><pmid>33144024</pmid><doi>10.1016/j.cyto.2020.155340</doi><tpages>18</tpages><orcidid>https://orcid.org/0000-0002-6457-5327</orcidid><orcidid>https://orcid.org/0000-0002-5450-0647</orcidid><orcidid>https://orcid.org/0000-0002-6618-4856</orcidid><orcidid>https://orcid.org/0000-0001-8462-5603</orcidid><orcidid>https://orcid.org/0000-0002-0564-9250</orcidid></addata></record> |
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| subjects | Animals Biochemistry & Molecular Biology Cell Biology Cross-Sectional Studies Cytokines Cytokines - metabolism Humans Immunology Inflammation - metabolism Interleukin-17 - biosynthesis Interleukin-33 - biosynthesis Interleukins - biosynthesis Life Sciences & Biomedicine Longitudinal Studies Mice Periodontitis Periodontitis - blood Periodontitis - metabolism Saliva Saliva - metabolism Science & Technology Serum T helper 17 cells Th17 Cells - metabolism |
| title | A review of T helper 17 cell-related cytokines in serum and saliva in periodontitis |
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