The MEK/ERK Network as a Therapeutic Target in Human Cancer

The RAS-RAF-MEK-ERK pathway is the most well-studied of the MAPK cascades and is critical for cell proliferation, differentiation, and survival. Abnormalities in regulation resulting from mutations in components of this pathway, particularly in upstream proteins, RAS and RAF, are responsible for a s...

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Veröffentlicht in:	Molecular cancer research 2021-03, Vol.19 (3), p.361-374
Hauptverfasser:	Barbosa, Renee, Acevedo, Lucila A., Marmorstein, Ronen
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Biology Life Sciences & Biomedicine Oncology Science & Technology
Online-Zugang:	Volltext
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