No effect of prior Dengue virus 1 infection in mouse dams on long-term behavioral profiles in offspring infected with Zika virus during gestation
•Infant offspring from DENV/ZIKV-infected dams showed decreased visual acuity.•Pups from all infected dams showed hypolocomotion during infancy of mice.•Both ZIKV and DENV1 infections triggers anxiolytic-like behavior in the offspring.•Late BDNF may prevent effects of infection on behavior and optic...
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| Veröffentlicht in: | Neuroscience letters 2020-11, Vol.739, p.135448-135448, Article 135448 |
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| creator | Costa, Karla Cristinne Mancini Brancaglion, Gustavo Andrade Almeida, Carolina Aparecida de Faria de Amorim, Gabriel Estevam Santos Veloso, Luciana Lopes Lião, Lucas da Silva de Souza, Gabriel Augusto Pires Pinheiro, Bruna Pereira Ângelo, Marilene Lopes Ruginsk, Silvia Graciela Brandão, Wesley Nogueira Marcourakis, Tania Ceron, Carla Speroni Coelho, Luiz Felipe Leomil Torres, Larissa Helena |
| description | •Infant offspring from DENV/ZIKV-infected dams showed decreased visual acuity.•Pups from all infected dams showed hypolocomotion during infancy of mice.•Both ZIKV and DENV1 infections triggers anxiolytic-like behavior in the offspring.•Late BDNF may prevent effects of infection on behavior and optic nerve development.
Zika virus (ZIKV) is a mosquito-borne Flavivirus structurally and antigenically related to Dengue virus (DENV). Zika virus has been associated with congenital anomalies and most ZIKV outbreaks have occurred in endemic areas of DENV. The present study investigated the effects of prior DENV serotype 1 (DENV1) immunity in immunocompetent female Swiss mice on gestational ZIKV infection in offspring. Physical/reflex development, locomotor activity, anxiety, visual acuity, and brain-derived neurotrophic factor (BDNF) levels were evaluated in offspring during infancy and adolescence. Anti-DENV1 and anti-ZIKV antibodies were detected in sera of the progenitors, whereas no ZIKV genomes were detected in the offspring brain. Pups from dams with only DENV1 immunity presented alterations of physical/reflex development. Pups from all infected dams exhibited time-related impairments in locomotor activity and anxiolytic-like behavior. Offspring from DENV/ZIKV-infected dams exhibited impairments in visual acuity during infancy but not during adolescence, which was consistent with morphometric analysis of the optic nerve. Pups from DENV1-, ZIKV-, and DENV/ZIKV-infected dams exhibited a decrease in BDNF levels during infancy and an increase during adolescence in distinct brain regions. In summary, we found no influence of prior DENV1 immunity on gestational ZIKV infection in offspring, with the exception of alterations of early visual parameters, and an increase in BDNF levels in the hippocampus during adolescence. |
| doi_str_mv | 10.1016/j.neulet.2020.135448 |
| format | Article |
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Zika virus (ZIKV) is a mosquito-borne Flavivirus structurally and antigenically related to Dengue virus (DENV). Zika virus has been associated with congenital anomalies and most ZIKV outbreaks have occurred in endemic areas of DENV. The present study investigated the effects of prior DENV serotype 1 (DENV1) immunity in immunocompetent female Swiss mice on gestational ZIKV infection in offspring. Physical/reflex development, locomotor activity, anxiety, visual acuity, and brain-derived neurotrophic factor (BDNF) levels were evaluated in offspring during infancy and adolescence. Anti-DENV1 and anti-ZIKV antibodies were detected in sera of the progenitors, whereas no ZIKV genomes were detected in the offspring brain. Pups from dams with only DENV1 immunity presented alterations of physical/reflex development. Pups from all infected dams exhibited time-related impairments in locomotor activity and anxiolytic-like behavior. Offspring from DENV/ZIKV-infected dams exhibited impairments in visual acuity during infancy but not during adolescence, which was consistent with morphometric analysis of the optic nerve. Pups from DENV1-, ZIKV-, and DENV/ZIKV-infected dams exhibited a decrease in BDNF levels during infancy and an increase during adolescence in distinct brain regions. In summary, we found no influence of prior DENV1 immunity on gestational ZIKV infection in offspring, with the exception of alterations of early visual parameters, and an increase in BDNF levels in the hippocampus during adolescence.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2020.135448</identifier><identifier>PMID: 33129847</identifier><language>eng</language><publisher>CLARE: Elsevier B.V</publisher><subject>Animals ; Anxiety ; BDNF ; Behavior ; Behavior, Animal ; Brain - immunology ; Brain - virology ; Brain-Derived Neurotrophic Factor - immunology ; Brain-Derived Neurotrophic Factor - metabolism ; Dengue - immunology ; Dengue virus 1 ; Development ; Female ; Life Sciences & Biomedicine ; Male ; Maze Learning ; Mice ; Neurosciences ; Neurosciences & Neurology ; Pregnancy ; Pregnancy Complications, Infectious - immunology ; Pregnancy Complications, Infectious - psychology ; Science & Technology ; Zika virus ; Zika Virus Infection - immunology ; Zika Virus Infection - psychology</subject><ispartof>Neuroscience letters, 2020-11, Vol.739, p.135448-135448, Article 135448</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>1</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000595874300002</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c362t-309fc85f57835bc858e37f181022f1f3bfebcf8517327c0d93ced6c3d890ac6d3</citedby><cites>FETCH-LOGICAL-c362t-309fc85f57835bc858e37f181022f1f3bfebcf8517327c0d93ced6c3d890ac6d3</cites><orcidid>0000-0002-0076-5017 ; 0000-0002-7065-7484 ; 0000-0001-8882-5792</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neulet.2020.135448$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,28252,45999</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33129847$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Costa, Karla Cristinne Mancini</creatorcontrib><creatorcontrib>Brancaglion, Gustavo Andrade</creatorcontrib><creatorcontrib>Almeida, Carolina Aparecida de Faria</creatorcontrib><creatorcontrib>de Amorim, Gabriel Estevam Santos</creatorcontrib><creatorcontrib>Veloso, Luciana Lopes</creatorcontrib><creatorcontrib>Lião, Lucas da Silva</creatorcontrib><creatorcontrib>de Souza, Gabriel Augusto Pires</creatorcontrib><creatorcontrib>Pinheiro, Bruna Pereira</creatorcontrib><creatorcontrib>Ângelo, Marilene Lopes</creatorcontrib><creatorcontrib>Ruginsk, Silvia Graciela</creatorcontrib><creatorcontrib>Brandão, Wesley Nogueira</creatorcontrib><creatorcontrib>Marcourakis, Tania</creatorcontrib><creatorcontrib>Ceron, Carla Speroni</creatorcontrib><creatorcontrib>Coelho, Luiz Felipe Leomil</creatorcontrib><creatorcontrib>Torres, Larissa Helena</creatorcontrib><title>No effect of prior Dengue virus 1 infection in mouse dams on long-term behavioral profiles in offspring infected with Zika virus during gestation</title><title>Neuroscience letters</title><addtitle>NEUROSCI LETT</addtitle><addtitle>Neurosci Lett</addtitle><description>•Infant offspring from DENV/ZIKV-infected dams showed decreased visual acuity.•Pups from all infected dams showed hypolocomotion during infancy of mice.•Both ZIKV and DENV1 infections triggers anxiolytic-like behavior in the offspring.•Late BDNF may prevent effects of infection on behavior and optic nerve development.
Zika virus (ZIKV) is a mosquito-borne Flavivirus structurally and antigenically related to Dengue virus (DENV). Zika virus has been associated with congenital anomalies and most ZIKV outbreaks have occurred in endemic areas of DENV. The present study investigated the effects of prior DENV serotype 1 (DENV1) immunity in immunocompetent female Swiss mice on gestational ZIKV infection in offspring. Physical/reflex development, locomotor activity, anxiety, visual acuity, and brain-derived neurotrophic factor (BDNF) levels were evaluated in offspring during infancy and adolescence. Anti-DENV1 and anti-ZIKV antibodies were detected in sera of the progenitors, whereas no ZIKV genomes were detected in the offspring brain. Pups from dams with only DENV1 immunity presented alterations of physical/reflex development. Pups from all infected dams exhibited time-related impairments in locomotor activity and anxiolytic-like behavior. Offspring from DENV/ZIKV-infected dams exhibited impairments in visual acuity during infancy but not during adolescence, which was consistent with morphometric analysis of the optic nerve. Pups from DENV1-, ZIKV-, and DENV/ZIKV-infected dams exhibited a decrease in BDNF levels during infancy and an increase during adolescence in distinct brain regions. In summary, we found no influence of prior DENV1 immunity on gestational ZIKV infection in offspring, with the exception of alterations of early visual parameters, and an increase in BDNF levels in the hippocampus during adolescence.</description><subject>Animals</subject><subject>Anxiety</subject><subject>BDNF</subject><subject>Behavior</subject><subject>Behavior, Animal</subject><subject>Brain - immunology</subject><subject>Brain - virology</subject><subject>Brain-Derived Neurotrophic Factor - immunology</subject><subject>Brain-Derived Neurotrophic Factor - metabolism</subject><subject>Dengue - immunology</subject><subject>Dengue virus 1</subject><subject>Development</subject><subject>Female</subject><subject>Life Sciences & Biomedicine</subject><subject>Male</subject><subject>Maze Learning</subject><subject>Mice</subject><subject>Neurosciences</subject><subject>Neurosciences & Neurology</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - immunology</subject><subject>Pregnancy Complications, Infectious - psychology</subject><subject>Science & Technology</subject><subject>Zika virus</subject><subject>Zika Virus Infection - immunology</subject><subject>Zika Virus Infection - psychology</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>EIF</sourceid><recordid>eNqNUcmO1DAQtRCIaQb-ACEfkVAaL3HsXJBQD5s0ggtcuFiJXe5xk8QQJz3iM_hjKiTMEXFyqeotrnqEPOVszxmvXp72A8wdTHvBBLakKktzj-y40aLQtRb3yY5JVhayLtkFeZTziTGmuCofkgspuahNqXfk18dEIQRwE02Bfh9jGukVDMcZ6DmOc6acxmEZxzRgRfs0Z6C-6TPFRpeGYzHB2NMWbpozkpsORVKIHeQFnkLIKDocNxXw9DZON_Rr_NZsBn7-Mz9CnprF5TF5EJouw5PtvSRf3r75fHhfXH969-Hw-rpwshJTIVkdnFFBaSNVi5UBqQM3nAkReJBtgNYFo7iWQjvma-nAV056U7PGVV5ekuerLv73x4zuto_ZQdc1A-CSVpSqMhVTWiK0XKFuTDmPECzu1DfjT8uZXcKwJ7uGYZcw7BoG0p5tDnPbg78j_b0-Al6sgFtoU8guwuDgDrbEVSujS4kVE4g2_48-xPWahzQPE1JfrVTAg54jjHaj-zhiKtan-O9VfgPdjMAa</recordid><startdate>20201120</startdate><enddate>20201120</enddate><creator>Costa, Karla Cristinne Mancini</creator><creator>Brancaglion, Gustavo Andrade</creator><creator>Almeida, Carolina Aparecida de Faria</creator><creator>de Amorim, Gabriel Estevam Santos</creator><creator>Veloso, Luciana Lopes</creator><creator>Lião, Lucas da Silva</creator><creator>de Souza, Gabriel Augusto Pires</creator><creator>Pinheiro, Bruna Pereira</creator><creator>Ângelo, Marilene Lopes</creator><creator>Ruginsk, Silvia Graciela</creator><creator>Brandão, Wesley Nogueira</creator><creator>Marcourakis, Tania</creator><creator>Ceron, Carla Speroni</creator><creator>Coelho, Luiz Felipe Leomil</creator><creator>Torres, Larissa Helena</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0076-5017</orcidid><orcidid>https://orcid.org/0000-0002-7065-7484</orcidid><orcidid>https://orcid.org/0000-0001-8882-5792</orcidid></search><sort><creationdate>20201120</creationdate><title>No effect of prior Dengue virus 1 infection in mouse dams on long-term behavioral profiles in offspring infected with Zika virus during gestation</title><author>Costa, Karla Cristinne Mancini ; 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Zika virus (ZIKV) is a mosquito-borne Flavivirus structurally and antigenically related to Dengue virus (DENV). Zika virus has been associated with congenital anomalies and most ZIKV outbreaks have occurred in endemic areas of DENV. The present study investigated the effects of prior DENV serotype 1 (DENV1) immunity in immunocompetent female Swiss mice on gestational ZIKV infection in offspring. Physical/reflex development, locomotor activity, anxiety, visual acuity, and brain-derived neurotrophic factor (BDNF) levels were evaluated in offspring during infancy and adolescence. Anti-DENV1 and anti-ZIKV antibodies were detected in sera of the progenitors, whereas no ZIKV genomes were detected in the offspring brain. Pups from dams with only DENV1 immunity presented alterations of physical/reflex development. Pups from all infected dams exhibited time-related impairments in locomotor activity and anxiolytic-like behavior. Offspring from DENV/ZIKV-infected dams exhibited impairments in visual acuity during infancy but not during adolescence, which was consistent with morphometric analysis of the optic nerve. Pups from DENV1-, ZIKV-, and DENV/ZIKV-infected dams exhibited a decrease in BDNF levels during infancy and an increase during adolescence in distinct brain regions. In summary, we found no influence of prior DENV1 immunity on gestational ZIKV infection in offspring, with the exception of alterations of early visual parameters, and an increase in BDNF levels in the hippocampus during adolescence.</abstract><cop>CLARE</cop><pub>Elsevier B.V</pub><pmid>33129847</pmid><doi>10.1016/j.neulet.2020.135448</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-0076-5017</orcidid><orcidid>https://orcid.org/0000-0002-7065-7484</orcidid><orcidid>https://orcid.org/0000-0001-8882-5792</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Neuroscience letters, 2020-11, Vol.739, p.135448-135448, Article 135448 |
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| subjects | Animals Anxiety BDNF Behavior Behavior, Animal Brain - immunology Brain - virology Brain-Derived Neurotrophic Factor - immunology Brain-Derived Neurotrophic Factor - metabolism Dengue - immunology Dengue virus 1 Development Female Life Sciences & Biomedicine Male Maze Learning Mice Neurosciences Neurosciences & Neurology Pregnancy Pregnancy Complications, Infectious - immunology Pregnancy Complications, Infectious - psychology Science & Technology Zika virus Zika Virus Infection - immunology Zika Virus Infection - psychology |
| title | No effect of prior Dengue virus 1 infection in mouse dams on long-term behavioral profiles in offspring infected with Zika virus during gestation |
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