Shared Mechanisms Govern HIV Transcriptional Suppression in Circulating CD103(+) and Gut CD4(+) T Cells

Latent HIV infection is the main barrier to cure, and most HIV-infected cells reside in the gut, where distinct but unknown mechanisms may promote viral latency. Transforming growth factor beta (TGF-beta), which induces the expression of CD103 on tissue-resident memory T cells, has been implicated i...

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Veröffentlicht in:	Journal of virology 2020-12, Vol.95 (2), Article 01331
Hauptverfasser:	Yukl, Steven A., Khan, Shahzada, Chen, Tsui-Hua, Trapecar, Martin, Wu, Frank, Xie, Guorui, Telwatte, Sushama, Fulop, Daniel, Pico, Alexander R., Laird, Gregory M., Ritter, Kristen D., Jones, Norman G., Lu, Chuanyi M., Siliciano, Robert F., Roan, Nadia R., Milush, Jeffrey M., Somsouk, Ma, Deeks, Steven G., Hunt, Peter W., Sanjabi, Shomyseh
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - metabolism Antiviral Agents - therapeutic use CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - virology DNA, Viral - metabolism Gastrointestinal Tract - immunology Gastrointestinal Tract - virology Gene Expression Regulation Genome and Regulation of Viral Gene Expression HIV Infections - drug therapy HIV Infections - virology HIV-1 - physiology Humans Integrin alpha Chains - metabolism Intraepithelial Lymphocytes - metabolism Intraepithelial Lymphocytes - virology Life Sciences & Biomedicine Proviruses - physiology Ribosomal Proteins - genetics RNA, Viral - metabolism Science & Technology T-Lymphocyte Subsets - metabolism T-Lymphocyte Subsets - virology Transcription, Genetic - genetics Virology Virus Latency
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