HLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis

The HLA-DR15 haplotype is the strongest genetic risk factor for multiple sclerosis (MS), but our understanding of how it contributes to MS is limited. Because autoreactive CD4+ T cells and B cells as antigen-presenting cells are involved in MS pathogenesis, we characterized the immunopeptidomes of t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell 2020-11, Vol.183 (5), p.1264-1281.e20
Hauptverfasser:	Wang, Jian, Jelcic, Ivan, Mühlenbruch, Lena, Haunerdinger, Veronika, Toussaint, Nora C., Zhao, Yingdong, Cruciani, Carolina, Faigle, Wolfgang, Naghavian, Reza, Foege, Magdalena, Binder, Thomas M.C., Eiermann, Thomas, Opitz, Lennart, Fuentes-Font, Laura, Reynolds, Richard, Kwok, William W., Nguyen, Julie T., Lee, Jar-How, Lutterotti, Andreas, Münz, Christian, Rammensee, Hans-Georg, Hauri-Hohl, Mathias, Sospedra, Mireia, Stevanovic, Stefan, Martin, Roland
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Alleles Antigens - immunology autoimmune disease autoreactive CD4 B cells B-Lymphocytes - immunology Biochemistry & Molecular Biology CD4-Positive T-Lymphocytes - immunology Cell Biology Cells, Cultured Cross Reactions - immunology cross-reactivity Female HLA cross-restriction HLA-DR Serological Subtypes - immunology HLA-DR-derived self-peptides HLA-DR15 molecules Humans Immunologic Memory immunopeptidome Life Sciences & Biomedicine Male Middle Aged Monocytes - immunology multiple sclerosis Multiple Sclerosis - immunology Peptides - immunology Proteome - metabolism Science & Technology T cell repertoire T cells T-Lymphocytes - immunology Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!