SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently identified coronavirus that causes the respiratory disease known as coronavirus disease 2019 (COVID-19). Despite the urgent need, we still do not fully understand the molecular basis of SARS-CoV-2 pathogenesis. Here, we compr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell 2020-11, Vol.183 (5), p.1325-1339.e21
Hauptverfasser:	Banerjee, Abhik K., Blanco, Mario R., Bruce, Emily A., Honson, Drew D., Chen, Linlin M., Chow, Amy, Bhat, Prashant, Ollikainen, Noah, Quinodoz, Sofia A., Loney, Colin, Thai, Jasmine, Miller, Zachary D., Lin, Aaron E., Schmidt, Madaline M., Stewart, Douglas G., Goldfarb, Daniel, De Lorenzo, Giuditta, Rihn, Suzannah J., Voorhees, Rebecca M., Botten, Jason W., Majumdar, Devdoot, Guttman, Mitchell
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Animals Chlorocebus aethiops COVID-19 - metabolism COVID-19 - virology HEK293 Cells Host-Pathogen Interactions Humans interferon Interferons - metabolism mRNA splicing NSP1 NSP16 NSP8 NSP9 Protein Biosynthesis protein trafficking Protein Transport RNA Splicing RNA, Messenger - metabolism RNA, Ribosomal, 18S - metabolism RNA, Small Cytoplasmic - chemistry RNA, Small Cytoplasmic - metabolism RNA-protein interactions SARS-CoV-2 SARS-CoV-2 - metabolism Signal Recognition Particle - chemistry Signal Recognition Particle - metabolism translation Vero Cells Viral Nonstructural Proteins - chemistry Viral Nonstructural Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!