A mixture of chloromethylisothiazolinone and methylisothiazolinone impairs rat vascular smooth muscle by depleting thiols and thereby elevating cytosolic Zn 2+ and generating reactive oxygen species

Chloromethylisothiazolinone (CMIT) and methylisothiazolinone (MIT) are biocidal preservatives and the active ingredients in Kathon CG, which contains ca. 1.5% mixture of CMIT and MIT at a ratio of 3:1 (CMIT/MIT). CMIT/MIT was misused as humidifier disinfectant products, which caused serious health p...

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Veröffentlicht in:	Archives of toxicology 2021-02, Vol.95 (2), p.541
Hauptverfasser:	Do, Van Quan, Seo, Yoon-Seok, Park, Jung-Min, Yu, Jieun, Duong, Men Thi Hoai, Nakai, Junichi, Kim, Sang-Kyum, Ahn, Hee-Chul, Lee, Moo-Yeol
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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