Chemical Modifications of Porous Shape Memory Polymers for Enhanced X-ray and MRI Visibility
The goal of this work was to develop a shape memory polymer (SMP) foam with visibility under both X-ray and magnetic resonance imaging (MRI) modalities. A porous polymeric material with these properties is desirable in medical device development for applications requiring thermoresponsive tissue sca...
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| Veröffentlicht in: | Molecules (Basel, Switzerland) Switzerland), 2020-10, Vol.25 (20), p.4660 |
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| creator | Fletcher, Grace K Nash, Landon D Graul, Lance M Jang, Lindy K Herting, Scott M Wilcox, Matthew D Touchet, Tyler J Sweatt, Ana Katarina McDougall, Mary P Wright, Steven M Maitland, Duncan J |
| description | The goal of this work was to develop a shape memory polymer (SMP) foam with visibility under both X-ray and magnetic resonance imaging (MRI) modalities. A porous polymeric material with these properties is desirable in medical device development for applications requiring thermoresponsive tissue scaffolds with clinical imaging capabilities. Dual modality visibility was achieved by chemically incorporating monomers with X-ray visible iodine-motifs and MRI visible monomers with gadolinium content. Physical and thermomechanical characterization showed the effect of increased gadopentetic acid (GPA) on shape memory behavior. Multiple compositions showed brightening effects in pilot, T
-weighted MR imaging. There was a correlation between the polymeric density and X-ray visibility on expanded and compressed SMP foams. Additionally, extractions and indirect cytocompatibility studies were performed to address toxicity concerns of gadolinium-based contrast agents (GBCAs). This material platform has the potential to be used in a variety of medical devices. |
| doi_str_mv | 10.3390/molecules25204660 |
| format | Article |
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-weighted MR imaging. There was a correlation between the polymeric density and X-ray visibility on expanded and compressed SMP foams. Additionally, extractions and indirect cytocompatibility studies were performed to address toxicity concerns of gadolinium-based contrast agents (GBCAs). This material platform has the potential to be used in a variety of medical devices.</description><identifier>ISSN: 1420-3049</identifier><identifier>EISSN: 1420-3049</identifier><identifier>DOI: 10.3390/molecules25204660</identifier><identifier>PMID: 33066091</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>3T3 Cells ; Acids ; Animals ; Biocompatibility ; biomaterial ; Brightening ; Composition effects ; Contrast agents ; Contrast media ; Contrast Media - chemistry ; Contrast Media - toxicity ; Foams ; Gadolinium - chemistry ; Gadopentetate dimeglumine ; Geometry ; Iodine ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Medical equipment ; Medical imaging ; Mice ; Microscopy, Electron, Scanning ; Morphology ; MRI visibility ; Nanoparticles ; Plastic foam ; Polymers ; polyurethanes ; Pore size ; Porosity ; Porous materials ; porous polymers ; Radiation ; Shape memory ; shape memory polymers ; Smart Materials - chemistry ; Spectroscopy, Fourier Transform Infrared ; Spectrum analysis ; Tensile Strength ; Thermomechanical properties ; Toxicity ; Transition Temperature ; X-ray visibility ; X-Rays</subject><ispartof>Molecules (Basel, Switzerland), 2020-10, Vol.25 (20), p.4660</ispartof><rights>2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-c68ef876600e29120efad3cd5fa89f8c1125742a9a177757d9615b1e219880c13</citedby><cites>FETCH-LOGICAL-c493t-c68ef876600e29120efad3cd5fa89f8c1125742a9a177757d9615b1e219880c13</cites><orcidid>0000-0001-7001-3761</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7587375/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7587375/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33066091$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fletcher, Grace K</creatorcontrib><creatorcontrib>Nash, Landon D</creatorcontrib><creatorcontrib>Graul, Lance M</creatorcontrib><creatorcontrib>Jang, Lindy K</creatorcontrib><creatorcontrib>Herting, Scott M</creatorcontrib><creatorcontrib>Wilcox, Matthew D</creatorcontrib><creatorcontrib>Touchet, Tyler J</creatorcontrib><creatorcontrib>Sweatt, Ana Katarina</creatorcontrib><creatorcontrib>McDougall, Mary P</creatorcontrib><creatorcontrib>Wright, Steven M</creatorcontrib><creatorcontrib>Maitland, Duncan J</creatorcontrib><title>Chemical Modifications of Porous Shape Memory Polymers for Enhanced X-ray and MRI Visibility</title><title>Molecules (Basel, Switzerland)</title><addtitle>Molecules</addtitle><description>The goal of this work was to develop a shape memory polymer (SMP) foam with visibility under both X-ray and magnetic resonance imaging (MRI) modalities. A porous polymeric material with these properties is desirable in medical device development for applications requiring thermoresponsive tissue scaffolds with clinical imaging capabilities. Dual modality visibility was achieved by chemically incorporating monomers with X-ray visible iodine-motifs and MRI visible monomers with gadolinium content. Physical and thermomechanical characterization showed the effect of increased gadopentetic acid (GPA) on shape memory behavior. Multiple compositions showed brightening effects in pilot, T
-weighted MR imaging. There was a correlation between the polymeric density and X-ray visibility on expanded and compressed SMP foams. Additionally, extractions and indirect cytocompatibility studies were performed to address toxicity concerns of gadolinium-based contrast agents (GBCAs). This material platform has the potential to be used in a variety of medical devices.</description><subject>3T3 Cells</subject><subject>Acids</subject><subject>Animals</subject><subject>Biocompatibility</subject><subject>biomaterial</subject><subject>Brightening</subject><subject>Composition effects</subject><subject>Contrast agents</subject><subject>Contrast media</subject><subject>Contrast Media - chemistry</subject><subject>Contrast Media - toxicity</subject><subject>Foams</subject><subject>Gadolinium - chemistry</subject><subject>Gadopentetate dimeglumine</subject><subject>Geometry</subject><subject>Iodine</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Medical equipment</subject><subject>Medical imaging</subject><subject>Mice</subject><subject>Microscopy, Electron, Scanning</subject><subject>Morphology</subject><subject>MRI visibility</subject><subject>Nanoparticles</subject><subject>Plastic foam</subject><subject>Polymers</subject><subject>polyurethanes</subject><subject>Pore size</subject><subject>Porosity</subject><subject>Porous materials</subject><subject>porous polymers</subject><subject>Radiation</subject><subject>Shape memory</subject><subject>shape memory polymers</subject><subject>Smart Materials - chemistry</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Spectrum analysis</subject><subject>Tensile Strength</subject><subject>Thermomechanical properties</subject><subject>Toxicity</subject><subject>Transition Temperature</subject><subject>X-ray visibility</subject><subject>X-Rays</subject><issn>1420-3049</issn><issn>1420-3049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNplkduKFDEQhoMo7kEfwBsJeN2aQ2eS3AgyrDqwg-IJL4SQTio7Gbo7s0m30G9v1lmXXbyqQ_76qsKP0AtKXnOuyZsh9eDmHgoTjLSrFXmETmnLSMNJqx_fy0_QWSl7QhhtqXiKTjgnVa3pKfq13sEQne3xNvkYajbFNBacAv6ccpoL_rqzB8BbGFJeaq9fBsgFh5TxxbizowOPfzbZLtiOHm-_bPCPWGIX-zgtz9CTYPsCz2_jOfr-_uLb-mNz-enDZv3usnGt5lPjVgqCkvUiAkxTRiBYz50XwSodlKOUCdkyqy2VUgrp9YqKjgKjWiniKD9HmyPXJ7s3hxwHmxeTbDR_GylfGZun6HowjLDgLVS6lm3b2U7VUgjOvSZ1jaust0fWYe4G8A7GKdv-AfThyxh35ir9NlIoyaWogFe3gJyuZyiT2ac5j_X_hglRLVCK8aqiR5XLqZQM4W4DJebGXPOfuXXm5f3T7ib-ucn_ANZUolU</recordid><startdate>20201013</startdate><enddate>20201013</enddate><creator>Fletcher, Grace K</creator><creator>Nash, Landon D</creator><creator>Graul, Lance M</creator><creator>Jang, Lindy K</creator><creator>Herting, Scott M</creator><creator>Wilcox, Matthew D</creator><creator>Touchet, Tyler J</creator><creator>Sweatt, Ana Katarina</creator><creator>McDougall, Mary P</creator><creator>Wright, Steven M</creator><creator>Maitland, Duncan J</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-7001-3761</orcidid></search><sort><creationdate>20201013</creationdate><title>Chemical Modifications of Porous Shape Memory Polymers for Enhanced X-ray and MRI Visibility</title><author>Fletcher, Grace K ; Nash, Landon D ; Graul, Lance M ; Jang, Lindy K ; Herting, Scott M ; Wilcox, Matthew D ; Touchet, Tyler J ; Sweatt, Ana Katarina ; McDougall, Mary P ; Wright, Steven M ; Maitland, Duncan J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-c68ef876600e29120efad3cd5fa89f8c1125742a9a177757d9615b1e219880c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>3T3 Cells</topic><topic>Acids</topic><topic>Animals</topic><topic>Biocompatibility</topic><topic>biomaterial</topic><topic>Brightening</topic><topic>Composition effects</topic><topic>Contrast agents</topic><topic>Contrast media</topic><topic>Contrast Media - chemistry</topic><topic>Contrast Media - toxicity</topic><topic>Foams</topic><topic>Gadolinium - chemistry</topic><topic>Gadopentetate dimeglumine</topic><topic>Geometry</topic><topic>Iodine</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Medical equipment</topic><topic>Medical imaging</topic><topic>Mice</topic><topic>Microscopy, Electron, Scanning</topic><topic>Morphology</topic><topic>MRI visibility</topic><topic>Nanoparticles</topic><topic>Plastic foam</topic><topic>Polymers</topic><topic>polyurethanes</topic><topic>Pore size</topic><topic>Porosity</topic><topic>Porous materials</topic><topic>porous polymers</topic><topic>Radiation</topic><topic>Shape memory</topic><topic>shape memory polymers</topic><topic>Smart Materials - chemistry</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>Spectrum analysis</topic><topic>Tensile Strength</topic><topic>Thermomechanical properties</topic><topic>Toxicity</topic><topic>Transition Temperature</topic><topic>X-ray visibility</topic><topic>X-Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fletcher, Grace K</creatorcontrib><creatorcontrib>Nash, Landon D</creatorcontrib><creatorcontrib>Graul, Lance M</creatorcontrib><creatorcontrib>Jang, Lindy K</creatorcontrib><creatorcontrib>Herting, Scott M</creatorcontrib><creatorcontrib>Wilcox, Matthew D</creatorcontrib><creatorcontrib>Touchet, Tyler J</creatorcontrib><creatorcontrib>Sweatt, Ana Katarina</creatorcontrib><creatorcontrib>McDougall, Mary P</creatorcontrib><creatorcontrib>Wright, Steven M</creatorcontrib><creatorcontrib>Maitland, Duncan J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Molecules (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fletcher, Grace K</au><au>Nash, Landon D</au><au>Graul, Lance M</au><au>Jang, Lindy K</au><au>Herting, Scott M</au><au>Wilcox, Matthew D</au><au>Touchet, Tyler J</au><au>Sweatt, Ana Katarina</au><au>McDougall, Mary P</au><au>Wright, Steven M</au><au>Maitland, Duncan J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemical Modifications of Porous Shape Memory Polymers for Enhanced X-ray and MRI Visibility</atitle><jtitle>Molecules (Basel, Switzerland)</jtitle><addtitle>Molecules</addtitle><date>2020-10-13</date><risdate>2020</risdate><volume>25</volume><issue>20</issue><spage>4660</spage><pages>4660-</pages><issn>1420-3049</issn><eissn>1420-3049</eissn><abstract>The goal of this work was to develop a shape memory polymer (SMP) foam with visibility under both X-ray and magnetic resonance imaging (MRI) modalities. A porous polymeric material with these properties is desirable in medical device development for applications requiring thermoresponsive tissue scaffolds with clinical imaging capabilities. Dual modality visibility was achieved by chemically incorporating monomers with X-ray visible iodine-motifs and MRI visible monomers with gadolinium content. Physical and thermomechanical characterization showed the effect of increased gadopentetic acid (GPA) on shape memory behavior. Multiple compositions showed brightening effects in pilot, T
-weighted MR imaging. There was a correlation between the polymeric density and X-ray visibility on expanded and compressed SMP foams. Additionally, extractions and indirect cytocompatibility studies were performed to address toxicity concerns of gadolinium-based contrast agents (GBCAs). This material platform has the potential to be used in a variety of medical devices.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33066091</pmid><doi>10.3390/molecules25204660</doi><orcidid>https://orcid.org/0000-0001-7001-3761</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 3T3 Cells Acids Animals Biocompatibility biomaterial Brightening Composition effects Contrast agents Contrast media Contrast Media - chemistry Contrast Media - toxicity Foams Gadolinium - chemistry Gadopentetate dimeglumine Geometry Iodine Magnetic resonance imaging Magnetic Resonance Imaging - methods Medical equipment Medical imaging Mice Microscopy, Electron, Scanning Morphology MRI visibility Nanoparticles Plastic foam Polymers polyurethanes Pore size Porosity Porous materials porous polymers Radiation Shape memory shape memory polymers Smart Materials - chemistry Spectroscopy, Fourier Transform Infrared Spectrum analysis Tensile Strength Thermomechanical properties Toxicity Transition Temperature X-ray visibility X-Rays |
| title | Chemical Modifications of Porous Shape Memory Polymers for Enhanced X-ray and MRI Visibility |
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