Dissecting Cellular Mechanisms of Long-Chain Acylcarnitines-Driven Cardiotoxicity: Disturbance of Calcium Homeostasis, Activation of Ca 2+ -Dependent Phospholipases, and Mitochondrial Energetics Collapse

Long-chain acylcarnitines (LCAC) are implicated in ischemia-reperfusion (I/R)-induced myocardial injury and mitochondrial dysfunction. Yet, molecular mechanisms underlying involvement of LCAC in cardiac injury are not sufficiently studied. It is known that in cardiomyocytes, palmitoylcarnitine (PC)...

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Veröffentlicht in:International journal of molecular sciences 2020-10, Vol.21 (20)
Hauptverfasser: Berezhnov, Alexey V, Fedotova, Evgeniya I, Nenov, Miroslav N, Kasymov, Vitaly A, Pimenov, Oleg Yu, Dynnik, Vladimir V
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Sprache:eng
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