N 6 -methyladenosine-dependent pri-miR-17-92 maturation suppresses PTEN/TMEM127 and promotes sensitivity to everolimus in gastric cancer

N -methyladenosine (m A) is the most common epigenetic RNA modification with essential roles in cancer progression. However, roles of m A and its regulator METTL3 on non-coding RNA in gastric cancer are unknown. In this study, we found elevated levels of m A and METTL3 in gastric cancer. Increased M...

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Veröffentlicht in:	Cell death & disease 2020-10, Vol.11 (10), p.836
Hauptverfasser:	Sun, Yiting, Li, Song, Yu, Wenbin, Zhao, Zeyi, Gao, Jing, Chen, Cheng, Wei, Meng, Liu, Teng, Li, Lanbo, Liu, Lian
Format:	Artikel
Sprache:	eng
Schlagworte:	Disease Progression Everolimus - pharmacology Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - genetics Humans Membrane Proteins - genetics Membrane Proteins - metabolism Methyltransferases - genetics PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism RNA, Long Noncoding - genetics Stomach Neoplasms - drug therapy Stomach Neoplasms - genetics TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism
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