Salvage treatment with plerixafor in poor mobilizing allogeneic stem cell donors: results of a prospective phase II-trial

We conducted a prospective clinical trial to investigate the safety and efficacy of plerixafor (P) in allogeneic peripheral blood stem cells (PBSC) donors with poor mobilization response to standard-dose granulocyte colony-stimulating factor (G-CSF), defined by

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2021-03, Vol.56 (3), p.635-645
Hauptverfasser:	Hölig, Kristina, Schmidt, Helmuth, Hütter, Gero, Kramer, Michael, Teipel, Raphael, Heidrich, Katharina, Zimmer, Kristin, Heidenreich, Falk, Blechschmidt, Matthias, Torosian, Tigran, Ordemann, Rainer, Kroschinsky, Frank, Rücker-Braun, Elke, Gopsca, Laszlo, Wagner-Drouet, Eva Maria, Oelschlaegel, Uta, Schmidt, Alexander H., Bornhäuser, Martin, Ehninger, Gerhard, Schetelig, Johannes
Format:	Artikel
Sprache:	eng
Schlagworte:	631/532/1542 692/308/2779/109/1941 Adverse events Antigens, CD34 Apheresis Benzylamines Biophysics Blood CD34 antigen Cell Biology Colony-stimulating factor Cyclams Drug therapy Granulocyte Colony-Stimulating Factor Hematology Hematopoietic Stem Cell Mobilization Hematopoietic Stem Cell Transplantation Hematopoietic stem cells Heterocyclic Compounds Humans Immunology Internal Medicine Leukocytes (granulocytic) Life Sciences & Biomedicine Medical research Medicine Medicine & Public Health Medicine, Experimental Oncology Organ donors Peripheral blood Peripheral Blood Stem Cells Prospective Studies Public Health Salvage Therapy Science & Technology Stem cell transplantation Stem Cells Transplantation
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Beschreibung
Zusammenfassung:	We conducted a prospective clinical trial to investigate the safety and efficacy of plerixafor (P) in allogeneic peripheral blood stem cells (PBSC) donors with poor mobilization response to standard-dose granulocyte colony-stimulating factor (G-CSF), defined by
ISSN:	0268-3369 1476-5365
DOI:	10.1038/s41409-020-01053-4