Using SHAPE-MaP To Model RNA Secondary Structure and Identify 3'UTR Variation in Chikungunya Virus

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus associated with debilitating arthralgia in humans. RNA secondary structure in the viral genome plays an important role in the lifecycle of alphaviruses; however, the specific role of RNA structure in regulating CHIKV replication is poorly unde...

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Veröffentlicht in:	Journal of virology 2020-11, Vol.94 (24)
Hauptverfasser:	Madden, Emily A, Plante, Kenneth S, Morrison, Clayton R, Kutchko, Katrina M, Sanders, Wes, Long, Kristin M, Taft-Benz, Sharon, Cruz Cisneros, Marta C, White, Ashlyn Morgan, Sarkar, Sanjay, Reynolds, Grace, Vincent, Heather A, Laederach, Alain, Moorman, Nathanial J, Heise, Mark T
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Animals Cell Line Chikungunya Fever - virology Chikungunya virus - genetics Chlorocebus aethiops Culicidae Cytopathogenic Effect, Viral Genome, Viral Mutation Nucleic Acid Conformation RNA, Viral - chemistry RNA, Viral - genetics Sequence Analysis Vero Cells Virus Replication - genetics
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